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	Transcriptomic and metabonomic analyses reveal roles of VPS 29 in carotenoid accumulation in adductor muscles of QN Orange scallops
	Song, Junlin1; Wang, Chunde1,2
发表期刊	GENOMICS
ISSN	0888-7543
	2021-07-01
卷号	113期号:4页码:2839-2846
关键词	Transcriptomic VPS29 Carotenoid deposition mRNA
DOI	10.1016/j.ygeno.2021.06.015
通讯作者	Wang, Chunde(chundewang2007@163.com)
英文摘要	Background: In our previous studies, we demonstrated that the accumulation of carotenoids in QN Orange scallops might be regulated by the vacuolar protein sorting 29 (VPS29) gene. VPS genes are involved in pigments accumulation (including carotenoids) in some species and VPS29 is known as the core component of the membrane transport complex Retromer. However, the possible mechanism of carotenoids accumulation underlying the VPS29 remains unexplored. This study aimed to further elucidate the roles of VPS29 in the carotenoid deposition. Results: Transcriptomic analyses revealed four differentially expressed genes related to carotenoid accumulation, including three down-regulated genes, low-density lipoprotein receptor domain class, scavenger receptor, Niemann Pick C1-like 1, and one up-regulated gene, ATP binding cassette transporter in RNAi group. Results from metabonomic analyses indicated increased profiles of retinol and decreased fatty acids between the RNAi and the control group. Conclusions: It thus speculated that VPS may be related to the accumulation of carotenoids as RNAi of VPS 29 seemed to result in a reduction in pectenolone through the blockage in the absorption of carotenoids and an accelerated cleavage of carotenoids into retinol.
资助机构	National Natural Science Foundation ; Earmarked Fund for Agriculture Seed Improvement Project of Shandong Province ; Earmarked Fund for Shandong Modern Agro-Industry Technology Research System ; Qingdao Agricultural University Foundation ; Shandong Province Natural Science Foundation
收录类别	SCI
语种	英语
关键词[WOS]	BOHAI RED ; TRANSPORTERS ; EXPRESSION ; RECEPTOR ; CELLS
研究领域[WOS]	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS记录号	WOS:000669212300002
引用统计	被引频次：1[WOS]   [WOS记录]     [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/29482
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Wang, Chunde
作者单位	1.Qingdao Agr Univ, Qingdao 266109, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Song, Junlin,Wang, Chunde. Transcriptomic and metabonomic analyses reveal roles of VPS 29 in carotenoid accumulation in adductor muscles of QN Orange scallops[J]. GENOMICS,2021,113(4):2839-2846.
APA	Song, Junlin,&Wang, Chunde.(2021).Transcriptomic and metabonomic analyses reveal roles of VPS 29 in carotenoid accumulation in adductor muscles of QN Orange scallops.GENOMICS,113(4),2839-2846.
MLA	Song, Junlin,et al."Transcriptomic and metabonomic analyses reveal roles of VPS 29 in carotenoid accumulation in adductor muscles of QN Orange scallops".GENOMICS 113.4(2021):2839-2846.

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Transcriptomic and m（2155KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览 请求全文

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