| Terpenoids from the Marine-Derived Fungus Aspergillus sp. RR-YLW-12, Associated with the Red Alga Rhodomela confervoides | |
Fang, Sheng-Tao1 ; Liu, Xiang-Hong1; Yan, Bing-Fei2; Miao, Feng-Ping1; Yin, Xiu-Li1; Li, Wen-Zuo2; Ji, Nai-Yun1
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| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 2021-06-25 | |
| 卷号 | 84期号:6页码:1763-1771 |
| DOI | 10.1021/acs.jnatprod.1c00021 |
| 通讯作者 | Ji, Nai-Yun(nyji@yic.ac.cn) |
| 英文摘要 | Two new meroterpenoids, aspermeroterpenes D and E (1 and 2), two new ophiobolin-type sesterterpenoids, the C-18 epimers of 18,19-dihydro-18-methoxy-19-hydroxyophiobolin P (6 and 7), and two new drimane-type sesquiterpenoids, 3S-hydroxystrobilactone A (8) and 6-epi-strobilactone A (9), along with 11 known terpenoids (3-5 and 10-17) were isolated from the cultures of the algicolous fungus Aspergillus sp. RR-YLW-12, derived from the red alga Rhodomela confervoides. The structures and relative configurations of new compounds were established by detailed spectroscopic analysis of NMR and HRMS experiments, and the absolute configurations were assigned by X-ray diffraction experiments and comparison of their experimental and calculated ECD spectra. Compound 1 features a rare 6/6/6/6/5 pentacyclic system with a meroterpenoid skeleton, and the structure of terretonin E (3) was revised in this study. Compound 4 showed significant inhibitory activities against three microalgae, Prorocentrum donghaiense, Heterosigma akashiwo, and Chattonella marina, with IC50 values of 10.5, 5.2, and 3.1 mu g/mL, respectively. |
| 资助机构 | Natural Science Foundation for Distinguished Young Scholars of Shandong Province ; Yantai Program for Science and Technique Development ; Youth Innovation Promotion Association of the CAS ; Taishan Scholar Project Special Funding |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | ABSOLUTE-CONFIGURATIONS ; SECONDARY METABOLITES |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:000668368800007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/29471 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 通讯作者 | Ji, Nai-Yun |
| 作者单位 | 1.Chinese Acad Sci, Ctr Ocean Megasci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Yantai Univ, Chem & Chem Engn Coll, Yantai 264005, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Sheng-Tao,Liu, Xiang-Hong,Yan, Bing-Fei,et al. Terpenoids from the Marine-Derived Fungus Aspergillus sp. RR-YLW-12, Associated with the Red Alga Rhodomela confervoides[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(6):1763-1771. |
| APA | Fang, Sheng-Tao.,Liu, Xiang-Hong.,Yan, Bing-Fei.,Miao, Feng-Ping.,Yin, Xiu-Li.,...&Ji, Nai-Yun.(2021).Terpenoids from the Marine-Derived Fungus Aspergillus sp. RR-YLW-12, Associated with the Red Alga Rhodomela confervoides.JOURNAL OF NATURAL PRODUCTS,84(6),1763-1771. |
| MLA | Fang, Sheng-Tao,et al."Terpenoids from the Marine-Derived Fungus Aspergillus sp. RR-YLW-12, Associated with the Red Alga Rhodomela confervoides".JOURNAL OF NATURAL PRODUCTS 84.6(2021):1763-1771. |
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