Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities
Mi, Yingqi1,2,3; Zhang, Jingjing1,2; Han, Xiangru4; Tan, Wenqiang1,2; Miao, Qin1,2,3; Cui, Jingmin1,2,3; Li, Qing1,2; Guo, Zhanyong1,2,3
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
2021-06-30
Volume181Pages:572-581
KeywordCarboxymethyl inulin Antioxidant Heterocyclic moieties
DOI10.1016/j.ijbiomac.2021.03.109
Corresponding AuthorGuo, Zhanyong(zhanyongguo@hotmail.com)
AbstractA series of novel inulin derivatives were designed and synthesized by the introduction of amino heterocyclic moieties onto carboxymethyl inulin with the aid of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hyd roxysucci ni mide. The target products were prepared via three - step chemical synthesis, and structures were identified by FTIR and H-1 NMR spectroscopy. Antioxidant activities of inulin derivatives including DPPH - radical scavenging assay, superoxide - radical scavenging assay, hydroxyl - radical scavenging assay, and reducing power were estimated. Meanwhile, their antifungal activities, including Colletotrichum lagenarium and Bottytis cinerea, were also explored by hyphal measurement. In particular, inulin derivatives bearing heterocyclic moieties exhibited a remarkable improvement over inulin on antioxidant and antifungal activities, and their bioactivities decreased roughly in the order of 2ATCMI > 4APCMI > 3APCMI > 2APCMI > 3ATCMI > CMI > inulin. Furthermore, the cytotoxicities of inulin derivatives against L929 cells were evaluated by CCK-8 in vitro, and all samples showed weak cytotoxicities. In a nutshell, the paper provides a practical approach to synthesize novel inulin derivatives with dramatically enhanced bioactivity and good biocompatibility. The product described in paper might serve as a new leading structure for further design of antioxidants or antifungal agents in biomedicine, cosmetics, and other fields. (C) 2021 Elsevier B.V. All rights reserved.
Funding OrganizationNational Key Research and Development Program of China ; Natural Science Foundation of Shandong Province of China
Indexed BySCI
Language英语
WOS KeywordIN-VITRO ; DERIVATIVES ; PREDICTION ; CHITOSANS
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS IDWOS:000656891400007
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/29383
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
Corresponding AuthorGuo, Zhanyong
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Yantai Univ, Coll Environm & Mat Engn, Yantai 264005, Peoples R China
Recommended Citation
GB/T 7714
Mi, Yingqi,Zhang, Jingjing,Han, Xiangru,et al. Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,181:572-581.
APA Mi, Yingqi.,Zhang, Jingjing.,Han, Xiangru.,Tan, Wenqiang.,Miao, Qin.,...&Guo, Zhanyong.(2021).Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,181,572-581.
MLA Mi, Yingqi,et al."Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 181(2021):572-581.
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