| A near-infrared fluorescent probe for evaluating glutamyl transpeptidase fluctuation in idiopathic pulmonary fibrosis cell and mice models | |
He, Na1,4; Wang, Yude1,4; Huang, Yan3; Wang, Xiaoyan3; Chen, Lingxin2,3 ; Lv, Changjun1,4
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| 发表期刊 | SENSORS AND ACTUATORS B-CHEMICAL
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| 2020-11-01 | |
| 卷号 | 322页码:8 |
| 关键词 | Fluorescent probe Near-infrared Glutamyl transpeptidase Idiopathic pulmonary fibrosis Fluorescence imaging |
| DOI | 10.1016/j.snb.2020.128565 |
| 通讯作者 | Huang, Yan(huangyanpy@163.com) ; Chen, Lingxin(lxchen@yic.ac.cn) ; Lv, Changjun(lucky_lcj@sina.com) |
| 英文摘要 | Idiopathic pulmonary fibrosis (IPF), whose early diagnosis and effective treatment still remain the focus of clinical studies, is a chronic, irreversible and finally fatal pulmonary disease. Glutamyl transpeptidase (GGT) has a potential relationship with the occurrence and development of IPF. Therefore, explore whether GGT can be applied as a biological indicator for the clinical identification and diagnosis of IPF, sensitive and accurate detection of GGT under physiological conditions is necessary. In this research, a new fluorescent probe Cy-GGT was exhibited for detecting GGT concentrations in pulmonary fibrosis cell and mice models. Cy-GGT was capable of rapidly and selectively detecting GGT in vitro. The probe was successfully applied for visualizing GGT in oxidative stress cell models, pulmonary fibrosis cells and mice models. The results revealed that intracellular GGT increased in the cells and mice models of pulmonary fibrosis. GGT plays a significant part in pulmonary fibrosis, and the GGT level abnormally expressed in the lung tissue may be employed as a potential biological indicator to diagnose IPF lesions. Furthermore, the discovery of the close relationship between IPF and GGT will provide a new idea for effective therapy of IPF in the future. |
| 资助机构 | National Nature Science Foundation of China ; science and technology innovation development plan of Yantai of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | GLUTATHIONE-S-TRANSFERASE ; GAMMA-GLUTAMYLTRANSPEPTIDASE ; AGGREGATION ; ASSOCIATION ; LIVER |
| 研究领域[WOS] | Chemistry ; Electrochemistry ; Instruments & Instrumentation |
| WOS记录号 | WOS:000573296500018 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/28491 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心 中国科学院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Huang, Yan; Chen, Lingxin; Lv, Changjun |
| 作者单位 | 1.Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China 3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 4.Binzhou Med Univ, Med Res Ctr, Inst Mol Med, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Na,Wang, Yude,Huang, Yan,et al. A near-infrared fluorescent probe for evaluating glutamyl transpeptidase fluctuation in idiopathic pulmonary fibrosis cell and mice models[J]. SENSORS AND ACTUATORS B-CHEMICAL,2020,322:8. |
| APA | He, Na,Wang, Yude,Huang, Yan,Wang, Xiaoyan,Chen, Lingxin,&Lv, Changjun.(2020).A near-infrared fluorescent probe for evaluating glutamyl transpeptidase fluctuation in idiopathic pulmonary fibrosis cell and mice models.SENSORS AND ACTUATORS B-CHEMICAL,322,8. |
| MLA | He, Na,et al."A near-infrared fluorescent probe for evaluating glutamyl transpeptidase fluctuation in idiopathic pulmonary fibrosis cell and mice models".SENSORS AND ACTUATORS B-CHEMICAL 322(2020):8. |
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| A near-infrared fluo（1713KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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