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New synthetic chitosan derivatives bearing benzenoid/heterocyclic moieties with enhanced antioxidant and antifungal activities
Mi, Yingqi1,2,3; Zhang, Jingjing1,2,3; Chen, Yuan1,2,3; Sun, Xueqi1,2,3; Tan, Wenqiang1,2; Li, Qing1,2; Guo, Zhanyong1,2,3
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
2020-12-01
Volume249Pages:8
KeywordCarboxymethyl chitosan Heterocyclic compounds Antifungal activity Antioxidant activity Cytotoxicity assay
DOI10.1016/j.carbpol.2020.116847
Corresponding AuthorGuo, Zhanyong(zhanyongguo@hotmail.com)
AbstractIn this paper, several novel chitosan derivatives bearing benzenoid / heterocyclic moieties were synthesized via introducing aminobenzene and heterocyclic compounds onto carboxymethyl chitosan. The specific structures of chitosan derivatives were confirmed by FTIR, H-1 NMR, and elemental analysis. Meanwhile, the antioxidant efficiencies of chitosan derivatives were assayed in vitro. In particular, all chitosan derivatives showed significant improvement in superoxide-radical scavenging activity and DPPH radical scavenging activity. Their antifungal activities against two plant pathogenic fungi (Colletotrichum lagenarium and Phomopsis asparagi) were estimated in vitro by hyphal measurement, and all products exhibited excellent antifungal activity. Besides, the cytotoxicity of them was also measured by CCK-8 in vitro on L929 cells, and all samples showed low cytotoxicity. The good biocompatibility and enhanced biological activity of new synthetic chitosan derivatives might be obvious ad-vantages, while applied in wide range of applications as antifungal agents or antioxidants in food, medicine, cosmetics, and other fields.
Funding OrganizationNational Key R&D Program of China ; Key R&D Program of Shandong Province ; Natural Science Foundation of Shandong Province of China
Indexed BySCI
Language英语
WOS KeywordIN-VITRO ; NANOPARTICLES ; BASES ; ACID ; NMR
WOS Research AreaChemistry ; Polymer Science
WOS IDWOS:000571541800001
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/28400
Collection海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
Corresponding AuthorGuo, Zhanyong
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Mi, Yingqi,Zhang, Jingjing,Chen, Yuan,et al. New synthetic chitosan derivatives bearing benzenoid/heterocyclic moieties with enhanced antioxidant and antifungal activities[J]. CARBOHYDRATE POLYMERS,2020,249:8.
APA Mi, Yingqi.,Zhang, Jingjing.,Chen, Yuan.,Sun, Xueqi.,Tan, Wenqiang.,...&Guo, Zhanyong.(2020).New synthetic chitosan derivatives bearing benzenoid/heterocyclic moieties with enhanced antioxidant and antifungal activities.CARBOHYDRATE POLYMERS,249,8.
MLA Mi, Yingqi,et al."New synthetic chitosan derivatives bearing benzenoid/heterocyclic moieties with enhanced antioxidant and antifungal activities".CARBOHYDRATE POLYMERS 249(2020):8.
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