Integrated hand-powered centrifugation and paper-based diagnosis with blood-in/answer-out capabilities

doi:10.1016/j.bios.2020.112282

	Integrated hand-powered centrifugation and paper-based diagnosis with blood-in/answer-out capabilities
	Li, Bowei1 ; Qi, Ji 1; Fu, Longwen1 ; Han, Jinglong 2,3; Choo, Jaebum 4; DeMello, Andrew J.5; Lin, Bingcheng 6; Chen, Lingxin1,7
发表期刊	BIOSENSORS & BIOELECTRONICS
ISSN	0956-5663
	2020-10-01
卷号	165 页码:9
关键词	Microfluidic paper-based device mu PAD On site diagnosis Cancer biomarker
DOI	10.1016/j.bios.2020.112282
通讯作者	Choo, Jaebum(jbchoo@cau.ac.kr) ; DeMello, Andrew J.(andrew.demello@chem.ethz.ch) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要	To date, 55% of inhabitants of the developing world still live in rural regions and they have a very urgent need to improve the level of disease diagnosis, especially in resource-limited settings. Herein, we present a microfluidic system that centrifuges whole blood and quantifies contained biomarkers in a rapid, feasible and integrated way. Such a device provides a blood-in/answer-out capability and is small enough to be carried by any individual in any environment. The successful integration a hand-powered centrifuge and immunoassay unit within a rotational paper-based device allows for diagnostic application by untrained users and in environments where access to electricity cannot be assumed. In addition, the low cost (similar to$ 0.5), light weight and small instrumental footprint make the device ideally suited for rapid on-site detection. To validate the applicability of the system in a clinical diagnostic testing, we successfully perform enzyme-linked immunosorbent assay (ELISA) analysis of carcinoembryonic antigen and alpha fetoprotein from human blood samples. We expect that this powerful platform technology will provide the opportunities for point-of-care diagnosis in resource-limited settings.
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Key Deployment Project of Centre for Ocean Mega-Research of Science, Chinese Academy of Sciences ; government-wide R&D Fund for the Research of Infectious Diseases in Korea ; National Research Foundation of Korea
收录类别	SCI
语种	英语
关键词[WOS]	MICROFLUIDIC DEVICES ; SEPARATION ; IMMUNOSENSORS ; IMMUNODEVICE ; IMMUNOASSAY ; PLASMA ; ASSAYS ; TIME
研究领域[WOS]	Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
WOS记录号	WOS:000566444800001
引用统计	被引频次：45[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/28375
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Choo, Jaebum; DeMello, Andrew J.; Chen, Lingxin
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China 2.Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China 3.Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China 4.Chung Ang Univ, Dept Chem, Seoul 06974, South Korea 5.Swiss Fed Inst Technol, Dept Chem & Appl Biosci, Inst Chem & Bioengn, Vladimir Prelog Weg 1, CH-8093 Zurich, Switzerland 6.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 7.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Li, Bowei,Qi, Ji,Fu, Longwen,et al. Integrated hand-powered centrifugation and paper-based diagnosis with blood-in/answer-out capabilities[J]. BIOSENSORS & BIOELECTRONICS,2020,165:9.
APA	Li, Bowei.,Qi, Ji.,Fu, Longwen.,Han, Jinglong.,Choo, Jaebum.,...&Chen, Lingxin.(2020).Integrated hand-powered centrifugation and paper-based diagnosis with blood-in/answer-out capabilities.BIOSENSORS & BIOELECTRONICS,165,9.
MLA	Li, Bowei,et al."Integrated hand-powered centrifugation and paper-based diagnosis with blood-in/answer-out capabilities".BIOSENSORS & BIOELECTRONICS 165(2020):9.

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