Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment
Li, Qing1,2; Mi, Yingqi1,3; Tan, Wenqiang1,2; Guo, Zhanyong1,2
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
2020-12-01
Volume164Pages:4279-4288
KeywordChitosan Free radical-scavenging Chemical modification
DOI10.1016/j.ijbiomac.2020.08.250
Corresponding AuthorGuo, Zhanyong(zhanyongguo@hotmail.com)
AbstractChitosan is an abundant and renewable polysaccharide, and chemical modification can be used to enhance the biological properties of chitosan. In this study, monophenol and ortho-diphenol were introduced to chitosan through chemical modification to get chitosan derivatives owned high antioxidant activity. Their free radical-scavenging activity against three free radicals and reduction ability was tested. Based on the four antioxidant assay, the antioxidant ability of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. The IC50 of inhibition of DPPH, hydroxyl ((OH)-O-center dot), and superoxide (O2 center dot-) radical-scavenging was 41-172, 10-89, and 14-38 mu g/mL, respectively. Meanwhile, ortho-diphenol was more efficient group than monophenol on the improvement of antioxidant ability of chitosan derivatives. The possible free radical-scavenging mechanism, including the number of the hydroxyl groups and the presence ortho-dihydroxy substitution for the antioxidant ability were discussed. In vitro studies demonstrated that the constructed chitosan derivatives have good biocompatibility, and good antioxidant capacity to reduce oxidative stress. Functionalization of chitosan with phenolic group allows the possible applications on the therapy of oxidative-related diseases. (C) 2020 Elsevier B.V. All rights reserved.
Funding OrganizationKey Technology Research and Development Program of Shandong ; Natural Science Foundation of Shandong ; National Key Research & Development Program of China
Indexed BySCI
Language英语
WOS KeywordANTIOXIDANT ACTIVITY ; INULIN DERIVATIVES ; OXIDATIVE STRESS ; FLAVONOIDS ; POLYPHENOLS ; MECHANISMS ; AGENTS ; DPPH ; DFT
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS IDWOS:000588093700407
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/27514
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
Corresponding AuthorGuo, Zhanyong
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shandong, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Li, Qing,Mi, Yingqi,Tan, Wenqiang,et al. Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,164:4279-4288.
APA Li, Qing,Mi, Yingqi,Tan, Wenqiang,&Guo, Zhanyong.(2020).Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,164,4279-4288.
MLA Li, Qing,et al."Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 164(2020):4279-4288.
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