YIC-IR  > 中科院烟台海岸带研究所知识产出
Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges
Wang, Tong1; Yang, Lintong1; Wang, Guangfei1; Han, Lei1; Chen, Kaili1; Liu, Ping1; Xu, Shumin1; Li, Dongsheng2; Xie, Zeping3; Mo, Xiumei2; Wang, Lei4; Liang, Haiyue5; Liu, Xuejie5; Zhang, Shumin3; Gao, Yonglin1
Source PublicationJOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
ISSN0883-9115
2021
Volume36Issue:1Pages:44-58
Keywordtilapia skin collagen collagen sponge biocompatibility wound healing hemostatic properties
DOI10.1177/0883911520981705
Corresponding AuthorZhang, Shumin(shumin_zhang@outlook.com) ; Gao, Yonglin(gylbill@163.com)
AbstractDialyzed tilapia skin collagen sponge (DTSCS) and self-assembled tilapia skin collagen sponge (STSCS) were prepared by freeze-drying. The raw components used in the fabrication of DTSCS and STSCS were separated and purified from tilapia fish skin. It is anticipated that these collagen sponges could be developed into medical dressings for hemostasis and wound healing. The aim of the present research was to explore the possibility of DTSCS and STSCS as medical dressings and compare their differences by scanning electron microscopy (SEM), water absorption measurement, differential scanning calorimetry (DSC), measurement of porosity, cytotoxicity, hemolysis, in vivo biocompatibility, and evaluation of hemostatic performance and wound healing. The results indicate that DTSCS and STSCS are suitable materials for use in medical applications with a loose and porous structure, high water absorption, high porosity, and high thermal stability. The materials also displayed good biocompatibility, including excellent blood compatibility, a lack of cytotoxicity, with no apparent rejection following implantation. STSCS exhibited rapid hemostasis and promoted healing, with slightly greater efficacy than DTSCS. The hemostatic properties and promotion of healing in DTSCS was similar to that of commercial bovine collagen sponge. Therefore, DTSCS and STSCS both represented excellent potential candidate materials for use as hemostatic agents and wound dressings.
Indexed BySCI
Language英语
WOS Research AreaBiotechnology & Applied Microbiology ; Materials Science ; Polymer Science
WOS IDWOS:000605949700004
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/26155
Collection中科院烟台海岸带研究所知识产出
中国科学院烟台海岸带研究所
Corresponding AuthorZhang, Shumin; Gao, Yonglin
Affiliation1.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
2.Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai, Peoples R China
3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China
5.Yantai Testing Ctr Food & Drug, Yantai, Peoples R China
Recommended Citation
GB/T 7714
Wang, Tong,Yang, Lintong,Wang, Guangfei,et al. Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges[J]. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,2021,36(1):44-58.
APA Wang, Tong.,Yang, Lintong.,Wang, Guangfei.,Han, Lei.,Chen, Kaili.,...&Gao, Yonglin.(2021).Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges.JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,36(1),44-58.
MLA Wang, Tong,et al."Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges".JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 36.1(2021):44-58.
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