New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii

doi:10.1016/j.fitote.2020.104470

	New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii
	Zhang, Jian-Long ; Zhou, Feng-Feng ; Li, You-Zhi ; Feng, Tao ; Jiang, Lin-Lin ; Jiang, Ren-Wang ; Zhang, Xing-Xiao ; Li, Xiao-Dong
发表期刊	FITOTERAPIA
ISSN	0367-326X
	2020-03
卷号	141 页码:104470
关键词	ANGULATA WITHANOLIDES
研究领域	Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1016/j.fitote.2020.104470
产权排序	[Zhang, Jian-Long; Jiang, Lin-Lin; Zhang, Xing-Xiao; Li, Xiao-Dong] Ludong Univ, Sch Life Sci, Yantai 264025, Peoples R China; [Zhang, Jian-Long; Li, You-Zhi; Feng, Tao; Jiang, Lin-Lin] Shandong Prov Key Lab Qual Safty Monitoring & Ris, Jinan 250022, Peoples R China; [Li, Xiao-Dong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Zhou, Feng-Feng] Linyi City People Hosp, Dept Infect Dis, Linyi 276000, Shandong, Peoples R China; [Zhang, Jian-Long; Jiang, Ren-Wang] Jinan Univ, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Peoples R China
通讯作者	Zhang, Xing-Xiao(zhangxingxiao@ldu.edu.cn) ; Li, Xiao-Dong(imnli@163.com)
作者部门	中科院烟台海岸带研究所知识产出
英文摘要	Phytochemical investigations on Physalis. alkekengi L. var. franchetii, a widespread traditional Chinese medicine, led to the isolation and identification of three new sesquiterpenoids physalisitins A-C (1-3). Their structures were elucidated by NMR and HRESIMS analysis, and their absolute configurations were determined by quantum chemical NMR and ECD calculations, as well as by comparing their optical rotation values with those known analogues. All of the isolated compounds were evaluated for their cyclooxygenase-2 (COX-2) inhibitory activity. Compounds 1-3 dose-dependently inhibited the COX-2 enzyme with IC50 values of 3.22 +/- 0.25, 6.35 +/- 0.84, and 11.13 +/- 1.47 mu M, respectively.
文章类型	Article
资助机构	National Key Research and Development Program of China [2016YFD0501010, 2017YFD-0500806, 2018YFD0501402] ; Key Research and Development Program of Shandong Province [2017NC210009, 2019GSF107091] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81600672] ; Major Agricultural Applied Technological Innovation Projects of Shandong Province ; Key Research and Development Plan of Yantai [2018XSCC045] ; Innovation Team Project for Modem Agricultural Industrious Technology System of Shandong Province [SDAIT-11-10]
收录类别	SCI
语种	英语
关键词[WOS]	ANGULATA ; WITHANOLIDES
研究领域[WOS]	Pharmacology & Pharmacy
WOS记录号	WOS:000518703900013
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/25082
专题	中国科学院烟台海岸带研究所知识产出
作者单位	1.Ludong Univ, Sch Life Sci, Yantai 264025, Peoples R China; 2.Shandong Prov Key Lab Qual Safty Monitoring & Ris, Jinan 250022, Peoples R China; 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; 4.Linyi City People Hosp, Dept Infect Dis, Linyi 276000, Shandong, Peoples R China; 5.Jinan Univ, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jian-Long,Zhou, Feng-Feng,Li, You-Zhi,et al. New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii[J]. FITOTERAPIA,2020,141:104470.
APA	Zhang, Jian-Long.,Zhou, Feng-Feng.,Li, You-Zhi.,Feng, Tao.,Jiang, Lin-Lin.,...&Li, Xiao-Dong.(2020).New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii.FITOTERAPIA,141,104470.
MLA	Zhang, Jian-Long,et al."New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii".FITOTERAPIA 141(2020):104470.

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