Trichobisabolins A-H, eight new bisabolane derivatives from the marine alga-epiphytic fungus Trichoderma asperellum Y6-2 | |
Shi, ZZ; Miao, FP; Fang, ST; Yin, XL; Ji, NY | |
发表期刊 | FITOTERAPIA |
ISSN | 0367-326X |
2019-04 | |
卷号 | 134页码:372-377 |
关键词 | Trichoderma asperellum Sesquiterpene Norsesquiterpene Bisabolane |
研究领域 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
DOI | 10.1016/j.fitote.2019.03.010 |
产权排序 | [Shi, Zhen-Zhen; Miao, Feng-Ping; Fang, Sheng-Tao; Yin, Xiu-Li; Ji, Nai-Yun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
通讯作者 | Ji, Nai-Yun(nyji@yic.ac.cn) |
作者部门 | 海岸带生物资源高效利用研究与发展中心 |
英文摘要 | Eight new bisabolane derivatives, trichobisabolins A-H, along with two known ones, (3R,6R,7R)-1,10-bisaboladien-3-ol (9) and (3R,6R,7S)-1,10-bisaboladien-3,6-diol (10) were isolated from the culture of Trichoderma asperellum Y6-2, obtained from the surface of the marine red alga Chondrus ocellatus. Their structures and relative configurations were identified by interpretation of 1D/2D NMR and MS data. Compounds 1-8 were assayed for inhibiting the growth of some marine-derived organisms, including four marine phytoplankton species, one marine zooplankton species, and five pathogenic bacteria. All of them exhibited inhibition against the marine phytoplanktons with IC50 values ranging from 2.1-78 mu g/mL, compounds 4 and 8 showed weak lethality to the marine zooplankton, and none of them had inhibition against the five pathogenic bacteria. |
文章类型 | Article |
资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31670355] ; Natural Science Foundation for Distinguished Young Scholars of Shandong Province [JQ201712] ; Key Cutting Edge Research Program of the Chinese Academy of Sciences [QYZDB-SSW-DQC013] ; Youth Innovation Promotion Association of CAS [2013138] ; Science and Technology Service Network Initiative of CAS [KFJ-STS-ZDTP-023] |
收录类别 | SCI |
语种 | 英语 |
关键词[WOS] | AGGREGATION PHEROMONE ; SESQUITERPENOIDS ; BUG |
研究领域[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
WOS记录号 | WOS:000468710300045 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/24963 |
专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
作者单位 | Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
推荐引用方式 GB/T 7714 | Shi, ZZ,Miao, FP,Fang, ST,et al. Trichobisabolins A-H, eight new bisabolane derivatives from the marine alga-epiphytic fungus Trichoderma asperellum Y6-2[J]. FITOTERAPIA,2019,134:372-377. |
APA | Shi, ZZ,Miao, FP,Fang, ST,Yin, XL,&Ji, NY.(2019).Trichobisabolins A-H, eight new bisabolane derivatives from the marine alga-epiphytic fungus Trichoderma asperellum Y6-2.FITOTERAPIA,134,372-377. |
MLA | Shi, ZZ,et al."Trichobisabolins A-H, eight new bisabolane derivatives from the marine alga-epiphytic fungus Trichoderma asperellum Y6-2".FITOTERAPIA 134(2019):372-377. |
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