| Seawater acidification increases copper toxicity: A multi-biomarker approach with a key marine invertebrate, the Pacific Oyster Crassostrea gigas | |
Cao, RW; Zhang, TY; Li, X; Zhao, YT; Wang, Q ; Yang, DL; Qu, Y; Liu, H; Dong, ZJ; Zhao, JM
| |
| 发表期刊 | AQUATIC TOXICOLOGY
 |
| ISSN | 0166-445X |
| 2019-05 | |
| 卷号 | 210页码:167-178 |
| 关键词 | Ocean acidification Copper Crassostrea gigas Bioconcentration Oxidative stress Multi-biomarker |
| 研究领域 | Marine & Freshwater Biology ; Toxicology |
| DOI | 10.1016/j.aquatox.2019.03.002 |
| 产权排序 | [Cao, Ruiwen; Zhang, Tianyu; Li, Xiao; Wang, Qing; Yang, Dinglong; Qu, Yi; Liu, Hui; Dong, Zhijun; Zhao, Jianmin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264117, Shandong, Peoples R China; [Cao, Ruiwen; Zhang, Tianyu; Li, Xiao; Wang, Qing; Yang, Dinglong; Qu, Yi; Liu, Hui; Dong, Zhijun; Zhao, Jianmin] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China; [Cao, Ruiwen; Zhang, Tianyu; Li, Xiao; Qu, Yi; Zhao, Jianmin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Biol Resources Utilizat, Yantai 264003, Shandong, Peoples R China; [Cao, Ruiwen; Zhang, Tianyu; Li, Xiao] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Zhao, Yuting] Shandong Marine Resource & Environm Res Inst, Yantai 264006, Peoples R China |
| 通讯作者 | Zhao, Jianmin(jmzhao@yic.ac.cn) |
| 作者部门 | 海岸带生物资源高效利用研究与发展中心 |
| 英文摘要 | Ocean acidification (OA) has been found to increase the release of free Cu2+ in seawater. However, only a handful of studies have investigated the influence of OA on Cu accumulation and cellular toxicity in bivalve species. In this study, Pacific oysters, Crassostrea gigas, were exposed to 25 mu g/L Cu2+ at three pH levels (8.1, 7.8 and 7.6) for 14 and 28 days. Physiological and histopathological parameters [(clearance rate (CR), respiration rate (RR), histopathological damage and condition index (CI)), oxidative stress and neurotoxicity biomarkers [superoxide dismutase (SOD) and glutathione transferase (GST) activities, lipid peroxidation (LPO) and acetylcholinesterase (AChE) activity], combined with glycolytic enzyme activities [pyruvate kinase (PK) and hexokinase (HK)] were investigated in C. gigas. The bioconcentration of Cu was increased in soft tissues of Cuexposed oysters under OA. Our results suggest that both OA and Cu could lead to physiological disturbance, oxidative stress, cellular damage, disturbance in energy metabolism and neurotoxicity in oysters. The inhibited CR, increased glycolytic enzymes activities and decreased CI suggested that the energy metabolism strategy adopted by oysters was not sustainable in the long term. Furthermore, integrated biomarker response (IBR) results found that OA and Cu exposure lead to severe stress to oysters, and co-exposure was the most stressful condition. Results from this study highlight the need to include OA in future environmental assessments of pollutants and hazardous materials to better elucidate the risks of those environmental perturbations. |
| 文章类型 | Article |
| 资助机构 | National Key Research and Development Program of China [2018YFC1406503] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31172388] ; Youth Foundation of Shandong Natural Science Foundation [ZR2016DP06] ; Two-Hundred Talents Plan of Yantai [Y839081021] ; Instrument Developing Project of the Chinese Academy of Sciences [YJKYYQ20170071] ; Youth Innovation Promotion Association, CAS [2016196] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | LONG-TERM EXPOSURE ; ISOPOD PORCELLIONIDES-PRUINOSUS ; OCEAN ACIDIFICATION ; OXIDATIVE STRESS ; MYTILUS-GALLOPROVINCIALIS ; PHYSIOLOGICAL ENERGETICS ; RUDITAPES-PHILIPPINARUM ; SUPEROXIDE-DISMUTASE ; ENVIRONMENTAL-STRESS ; ENZYME-ACTIVITIES |
| 研究领域[WOS] | Marine & Freshwater Biology ; Toxicology |
| WOS记录号 | WOS:000464481800016 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24950 |
| 专题 | 支撑部门_中国科学院牟平海岸带环境综合试验站 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 中国科学院海岸带环境过程与生态修复重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264117, Shandong, Peoples R China; 2.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China; 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Biol Resources Utilizat, Yantai 264003, Shandong, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 5.Shandong Marine Resource & Environm Res Inst, Yantai 264006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, RW,Zhang, TY,Li, X,et al. Seawater acidification increases copper toxicity: A multi-biomarker approach with a key marine invertebrate, the Pacific Oyster Crassostrea gigas[J]. AQUATIC TOXICOLOGY,2019,210:167-178. |
| APA | Cao, RW.,Zhang, TY.,Li, X.,Zhao, YT.,Wang, Q.,...&Zhao, JM.(2019).Seawater acidification increases copper toxicity: A multi-biomarker approach with a key marine invertebrate, the Pacific Oyster Crassostrea gigas.AQUATIC TOXICOLOGY,210,167-178. |
| MLA | Cao, RW,et al."Seawater acidification increases copper toxicity: A multi-biomarker approach with a key marine invertebrate, the Pacific Oyster Crassostrea gigas".AQUATIC TOXICOLOGY 210(2019):167-178. |
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