Single-nucleotide polymorphisms of APE1 associated with risk and prognosis of vitiligo in a Han Chinese population

doi:10.17219/acem/68364

YIC-IR > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物学与生物资源保护实验室

	Single-nucleotide polymorphisms of APE1 associated with risk and prognosis of vitiligo in a Han Chinese population
	Chen, XJ ; Chang, LL ; Wang, Q ; Han, CY ; Li, WJ ; Tian, FJ ; Liu, LQ ; Xia, XJ
发表期刊	ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
ISSN	1899-5276
	2019-09
卷号	28 期号:9 页码:1249-1255
关键词	vitiligo APE1 141T > G Asp148Glu risk of vitiligo
研究领域	Medicine, Research & Experimental
DOI	10.17219/acem/68364
产权排序	[Chen, Xian-Jin; Wang, Qi; Han, Chun-Yu; Xia, Xn-Juan] Qingdao Univ, Med Coll, Dept Dermatol, Affiliated Yantai Yuhuangding Hosp, Yantai, Peoples R China; [Chang, Li-Li] Qingdao Univ, Med Coll, Dept Intens Care Unit, Affiliated Yantai Yuhuangding Hosp, Yantai, Peoples R China; [Li, Wen-Jun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Beijing, Peoples R China; [Tian, Fu-Jun; Liu, Li-Qian] Linyi Peoples Hosp, Dept Dermatol, Linyi, Shandong, Peoples R China
通讯作者	Chen, Xian-Jin(chenxianjin_yt@126.com)
作者部门	海岸带生物学与生物资源保护实验室
英文摘要	Background. The single-nucleotide polymorphisms (SNPs) of apurinic/apyrimidinicendonuclease 1 (APE1), which has been implicated in cancers and the DNA base excision repair (BER) process, have not been thoroughly investigated in association with the risks of oxidative stress-related vitiligo. Objectives. The aim of this study is to investigate associations between APE1 single-nucleotide polymorphisms 141T > G and 1349T > G and risk and prognosis of vitiligo. Material and methods. From June 2013 to June 2015, a total of 460 vitiligo patients were randomly recruited as a case group; 200 of these patients received narrow bound ultraviolet B (NB-UVB) treatment. Meanwhile, 460 healthy controls were included as a control group. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to explore the distribution frequencies of genotypes. Results. Significant differences were detected between the case group and the control group in the frequencies of the 141T > G and 1349T > G genotypes. At 141T > G, compared with patients carrying the TG + GG genotype, male patients carrying the TT genotype aged more than 20 years with active non-segmental vitiligo, without a family history of vitiligo or other autoimmune diseases, exhibited an increased risk of vitiligo. Binary logistic regression analysis demonstrated that the TT genotype at 141T > G and the non-TT genotype at 1349T > G were independent risk factors for vitiligo development. At 1349T > G, compared with patients carrying the TT genotype, male patients carrying the TG + GG genotype aged more than 20 years with active non-segmental vitiligo, without a family history of vitiligo or other autoimmune diseases, exhibited an increased risk of vitiligo. Moreover, patients carrying 141TG + GG or 1349 TT genotypes had better photochromic effects, lower cumulative radiation doses, shorter treatment times, and earlier first photochromic times.
文章类型	Article
收录类别	SCI
语种	英语
关键词[WOS]	DNA-REPAIR ; GENERALIZED VITILIGO ; GENETIC-VARIANTS ; EXCISION ; RECURRENCE ; DISEASE
研究领域[WOS]	Medicine, Research & Experimental
WOS记录号	WOS:000488601100014
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/24864
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位	1.Qingdao Univ, Med Coll, Dept Dermatol, Affiliated Yantai Yuhuangding Hosp, Yantai, Peoples R China; 2.Qingdao Univ, Med Coll, Dept Intens Care Unit, Affiliated Yantai Yuhuangding Hosp, Yantai, Peoples R China; 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Beijing, Peoples R China; 4.Linyi Peoples Hosp, Dept Dermatol, Linyi, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Chen, XJ,Chang, LL,Wang, Q,et al. Single-nucleotide polymorphisms of APE1 associated with risk and prognosis of vitiligo in a Han Chinese population[J]. ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE,2019,28(9):1249-1255.
APA	Chen, XJ.,Chang, LL.,Wang, Q.,Han, CY.,Li, WJ.,...&Xia, XJ.(2019).Single-nucleotide polymorphisms of APE1 associated with risk and prognosis of vitiligo in a Han Chinese population.ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE,28(9),1249-1255.
MLA	Chen, XJ,et al."Single-nucleotide polymorphisms of APE1 associated with risk and prognosis of vitiligo in a Han Chinese population".ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE 28.9(2019):1249-1255.