Radiation-induced intestinal damage: latest molecular and clinical developments

doi:10.2217/fon-2019-0416

YIC-IR > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物学与生物资源保护实验室

	Radiation-induced intestinal damage: latest molecular and clinical developments
	Lu, LN ; Li, WJ; Chen, LH ; Su, Q ; Wang, YB ; Guo, Z ; Lu, YJ ; Liu, B; Qin, S
发表期刊	FUTURE ONCOLOGY
ISSN	1479-6694
	2019-12
卷号	15 期号:35 页码:4105-4118
关键词	cancer intestinal damage ionizing radiation radiation enteritis radiation enteropathy
研究领域	Oncology
DOI	10.2217/fon-2019-0416
产权排序	[Lu, Lina; Liu, Bin] Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Gansu, Peoples R China; [Li, Wenjun; Qin, Song] Chinese Acad Sci, Yantai Inst Costal Zone Res, Key Lab Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Lu, Lina; Chen, Lihua; Su, Qiong; Wang, Yanbin; Lu, Yongjuan] Northwest Minzu Univ, Sch Chem Engn, Lanzhou 730000, Gansu, Peoples R China; [Li, Wenjun; Qin, Song] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China; [Guo, Zhong] Northwest Minzu Univ, Med Coll, Lanzhou 730000, Gansu, Peoples R China; [Liu, Bin] Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Gansu, Peoples R China
通讯作者	Liu, Bin(binliu_edu@sina.com)
作者部门	海岸带生物学与生物资源保护实验室
英文摘要	Aim: To systematically review the prophylactic and therapeutic interventions for reducing the incidence or severity of intestinal symptoms among cancer patients receiving radiotherapy. Materials & methods: A literature search was conducted in the PubMed database using various search terms, including 'radiation enteritis', 'radiation enteropathy', 'radiation-induced intestinal disease', 'radiation-induced intestinal damage' and 'radiation mucositis'. The search was limited to in vivo studies, clinical trials and meta-analyses published in English with no limitation on publication date. Other relevant literature was identified based on the reference lists of selected studies. Results: The pathogenesis of acute and chronic radiation-induced intestinal damage as well as the prevention and treatment approaches were reviewed. Conclusion: There is inadequate evidence to strongly support the use of a particular strategy to reduce radiation-induced intestinal damage. More high-quality randomized controlled trials are required for interventions with limited evidence suggestive of potential benefits.
文章类型	Review
资助机构	National Key Research and Development Program of China [2018YFD0901102] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81560508, 51563022, 51562033] ; Northwest Minzu University's Double First-class and Characteristic Development Guide Special Funds-Chemistry Key Disciplines in Gansu Province [11080316]
收录类别	SCI
语种	英语
关键词[WOS]	RAT SMALL-INTESTINE ; STEM-CELLS ; IONIZING-RADIATION ; GASTROINTESTINAL TOXICITY ; INDUCED APOPTOSIS ; STROMAL CELLS ; UP-REGULATION ; SMALL-BOWEL ; INJURY ; RADIOTHERAPY
研究领域[WOS]	Oncology
WOS记录号	WOS:000502552400010
引用统计	被引频次：44[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/24801
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位	1.Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Gansu, Peoples R China; 2.Chinese Acad Sci, Yantai Inst Costal Zone Res, Key Lab Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 3.Northwest Minzu Univ, Sch Chem Engn, Lanzhou 730000, Gansu, Peoples R China; 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China; 5.Northwest Minzu Univ, Med Coll, Lanzhou 730000, Gansu, Peoples R China; 6.Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Lu, LN,Li, WJ,Chen, LH,et al. Radiation-induced intestinal damage: latest molecular and clinical developments[J]. FUTURE ONCOLOGY,2019,15(35):4105-4118.
APA	Lu, LN.,Li, WJ.,Chen, LH.,Su, Q.,Wang, YB.,...&Qin, S.(2019).Radiation-induced intestinal damage: latest molecular and clinical developments.FUTURE ONCOLOGY,15(35),4105-4118.
MLA	Lu, LN,et al."Radiation-induced intestinal damage: latest molecular and clinical developments".FUTURE ONCOLOGY 15.35(2019):4105-4118.

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