Facile synthesis of zirconia-coated mesoporous silica particles by hydrothermal strategy under low potential of hydrogen conditions and functionalization with dodecylphosphonic acid for high-performance liquid chromatography
Song, ZH; Li, SH; Guan, YF; Wang, S; Wang, YH; Yang, GQ; Zhang, XC; Li, JH; Song, WH; Zhou, CM; Chen, LX
Source PublicationJOURNAL OF CHROMATOGRAPHY A
ISSN0021-9673
2020-02-08
Volume1612Pages:460659
KeywordZrO2/SiO2-n synthesis Dodecylphosphonic acid Hydrophilic interaction chromatography (HILIC) Reversed-phase liquid chromatography (RPLC)
MOST Discipline CatalogueBiochemical Research Methods ; Chemistry, Analytical
DOI10.1016/j.chroma.2019.460659
Contribution Rank[Song, Zhihua; Wang, Yinghao; Yang, Gangqiang; Zhang, Xiaochen; Song, Wenhao; Zhou, Chuanming] Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China; [Li, Shenghong; Guan, Yafeng; Wang, Shuo] Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China; [Li, Jinhua; Chen, Lingxin] Chinese Acad Sci, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
Department海岸带环境工程技术研究与发展中心
AbstractIn this work, multilayer zirconia-coated silica (ZrO2/SiO2-n) microspheres were successfully produced by a straightforward hydrothermal procedure with a low concentration of Zr4+ (5 mM) under low potential of hydrogen (pH) conditions (pH = = 2). The obtained ZrO2/SiO2-n materials exhibited favorable characteristics for high-performance liquid chromatography (HPLC) separation, including high surface area and pore volume, good pore structure, narrow particle size, and pore size distribution. In addition, the zirconia coverage in the mesopores was confirmed by soaking the material in 1 M NaOH solution, with the particles showing strong resistance to the basic solution. The obtained ZrO2/SiO2-n stationary phases were packed into a fused-silica capillary tubing for the separation of alkaloids in hydrophilic interaction chromatography (HILIC) mode, and a column efficiency of 47,800 plates/m was obtained for berberine on a ZrO2/SiO2-6 micro column. The ZrO2/SiO2-6 microspheres were further modified by dodecylphosphonic acid (C12P-2-ZrO2/SiO2-6); the C12P-2-ZrO2/SiO2-6 material showed great potential for application in reversed-phase liquid chromatography (RPLC) mode. The C12P-2-ZrO2/SiO2-6 micro column showed a column efficiency of 55,000 plates/m for naphthalene and 51,300 plates/m for benzene. (C) 2019 Elsevier B.V. All rights reserved.
SubtypeArticle
Indexed BySCI
Language英语
WOS KeywordPACKED CAPILLARY COLUMNS ; STATIONARY-PHASE ; NANOPARTICLES ; TITANIA ; ALUMINA ; METHODOLOGY ; NANOSHELLS ; SPHERES
WOS Research AreaBiochemical Research Methods ; Chemistry, Analytical
WOS IDWOS:000514749200024
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/24753
Collection中科院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
Affiliation1.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China;
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China;
3.Chinese Acad Sci, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
Recommended Citation
GB/T 7714
Song, ZH,Li, SH,Guan, YF,et al. Facile synthesis of zirconia-coated mesoporous silica particles by hydrothermal strategy under low potential of hydrogen conditions and functionalization with dodecylphosphonic acid for high-performance liquid chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2020,1612:460659.
APA Song, ZH.,Li, SH.,Guan, YF.,Wang, S.,Wang, YH.,...&Chen, LX.(2020).Facile synthesis of zirconia-coated mesoporous silica particles by hydrothermal strategy under low potential of hydrogen conditions and functionalization with dodecylphosphonic acid for high-performance liquid chromatography.JOURNAL OF CHROMATOGRAPHY A,1612,460659.
MLA Song, ZH,et al."Facile synthesis of zirconia-coated mesoporous silica particles by hydrothermal strategy under low potential of hydrogen conditions and functionalization with dodecylphosphonic acid for high-performance liquid chromatography".JOURNAL OF CHROMATOGRAPHY A 1612(2020):460659.
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