Differential biological effects in two pedigrees of clam Ruditapes philippinarum exposed to cadmium using iTRAQ-based proteomics | |
Lu, Zhen; Wang, Shuang; Shan, Xiujuan; Ji, Chenglong; Wu, Huifeng | |
发表期刊 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY |
ISSN | 1382-6689 |
2019-01 | |
卷号 | 65页码:66-72 |
关键词 | Ruditapes philippinarum Pedigrees Cadmium Proteomic profiling |
研究领域 | Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology |
DOI | 10.1016/j.etap.2018.12.002 |
产权排序 | [Lu, Zhen; Wang, Shuang; Ji, Chenglong; Wu, Huifeng] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Shan, Xiujuan; Ji, Chenglong; Wu, Huifeng] Qingdao Natl Lab Marine Sci & Technol, Funct Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China; [Lu, Zhen; Wang, Shuang] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Shan, Xiujuan] Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Shandong Prov Key Lab Fishery Resources & Ecol En, Key Lab Sustainable Dev Marine Fisheries,Minist A, Qingdao 266071, Peoples R China |
作者部门 | 海岸带环境过程实验室 |
英文摘要 | Due to the industrial discharges, cadmium (Cd) has been one of typical heavy metal pollutants in the Bohai Sea. Manila clam Ruditapes philippinarwn is frequently used for pollution biomonitoring and consists of several pedigrees, of which White and Zebra clams are the dominant pedigrees along the Bohai Sea coast. However, limited attention has been paid on the differential biological effects in different pedigrees of clam to heavy metals. In this work, the proteome profiling analysis was performed to reveal the differential proteomic responses in White and Zebra clams to Cd exposure (200 mu g/L) for 48 h, followed by bioinformatical analysis. The proteomic investigations showed that Cd treatment induced more differentially expressed proteins (DEPs) in White clam samples than in Zebra clam samples. Based on the DEPs, we found that some key biological processes consisting of immune response and metabolism were commonly induced in both two pedigrees of clam. Uniquely, some processes related to cellular signaling, proteolysis and energy production were enhanced in Cd-treated White clam samples. Comparatively, the depletion in some unique processes on proteolysis and energy production was elicited in Cd-treated Zebra clam samples, as well as disorder in gene expression. Moreover, Cd exposure caused increases in CAT and POD activities in White clam samples and decreases in SOD and CAT activities in Zebra clams samples, which were consistent with the proteomic responses. Overall, these findings confirmed the differential biological effects of White and Zebra clams to Cd treatment, suggesting that the pedigree of animal should be taken into consideration in ecotoxicology studies. |
文章类型 | Article |
资助机构 | National Key Basic Research Program of China [2015CB453303, 2015CB453302] ; NSFC [41676114, 41506138] ; Young Taishan Scholars Program of Shandong Province ; Qingdao National Laboratory for Marine Science and Technology [QNLM201701] ; Strategic Priority Research Program of the Chinese Academy of Science [XDA11020702] ; Youth Innovation Promotion Association CAS [2015169] |
收录类别 | SCI |
语种 | 英语 |
关键词[WOS] | MUSSELS MYTILUS-GALLOPROVINCIALIS ; GENDER-SPECIFIC RESPONSES ; STRESS ; BIOACCUMULATION ; ENDOCYTOSIS ; POLLUTANTS ; ORGANISMS ; INFECTION ; POLLUTION ; TOXICITY |
研究领域[WOS] | Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology |
WOS记录号 | WOS:000457814500011 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/24614 |
专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室 中国科学院海岸带环境过程与生态修复重点实验室 |
作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; 2.Qingdao Natl Lab Marine Sci & Technol, Funct Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Shandong Prov Key Lab Fishery Resources & Ecol En, Key Lab Sustainable Dev Marine Fisheries,Minist A, Qingdao 266071, Peoples R China |
推荐引用方式 GB/T 7714 | Lu, Zhen,Wang, Shuang,Shan, Xiujuan,et al. Differential biological effects in two pedigrees of clam Ruditapes philippinarum exposed to cadmium using iTRAQ-based proteomics[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2019,65:66-72. |
APA | Lu, Zhen,Wang, Shuang,Shan, Xiujuan,Ji, Chenglong,&Wu, Huifeng.(2019).Differential biological effects in two pedigrees of clam Ruditapes philippinarum exposed to cadmium using iTRAQ-based proteomics.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,65,66-72. |
MLA | Lu, Zhen,et al."Differential biological effects in two pedigrees of clam Ruditapes philippinarum exposed to cadmium using iTRAQ-based proteomics".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 65(2019):66-72. |
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