Differential biological effects in two pedigrees of clam Ruditapes philippinarum exposed to cadmium using iTRAQ-based proteomics
Lu, Zhen; Wang, Shuang; Shan, Xiujuan; Ji, Chenglong; Wu, Huifeng
发表期刊ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
ISSN1382-6689
2019-01
卷号65页码:66-72
关键词Ruditapes philippinarum Pedigrees Cadmium Proteomic profiling
研究领域Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
DOI10.1016/j.etap.2018.12.002
产权排序[Lu, Zhen; Wang, Shuang; Ji, Chenglong; Wu, Huifeng] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Shan, Xiujuan; Ji, Chenglong; Wu, Huifeng] Qingdao Natl Lab Marine Sci & Technol, Funct Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China; [Lu, Zhen; Wang, Shuang] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Shan, Xiujuan] Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Shandong Prov Key Lab Fishery Resources & Ecol En, Key Lab Sustainable Dev Marine Fisheries,Minist A, Qingdao 266071, Peoples R China
作者部门海岸带环境过程实验室
英文摘要Due to the industrial discharges, cadmium (Cd) has been one of typical heavy metal pollutants in the Bohai Sea. Manila clam Ruditapes philippinarwn is frequently used for pollution biomonitoring and consists of several pedigrees, of which White and Zebra clams are the dominant pedigrees along the Bohai Sea coast. However, limited attention has been paid on the differential biological effects in different pedigrees of clam to heavy metals. In this work, the proteome profiling analysis was performed to reveal the differential proteomic responses in White and Zebra clams to Cd exposure (200 mu g/L) for 48 h, followed by bioinformatical analysis. The proteomic investigations showed that Cd treatment induced more differentially expressed proteins (DEPs) in White clam samples than in Zebra clam samples. Based on the DEPs, we found that some key biological processes consisting of immune response and metabolism were commonly induced in both two pedigrees of clam. Uniquely, some processes related to cellular signaling, proteolysis and energy production were enhanced in Cd-treated White clam samples. Comparatively, the depletion in some unique processes on proteolysis and energy production was elicited in Cd-treated Zebra clam samples, as well as disorder in gene expression. Moreover, Cd exposure caused increases in CAT and POD activities in White clam samples and decreases in SOD and CAT activities in Zebra clams samples, which were consistent with the proteomic responses. Overall, these findings confirmed the differential biological effects of White and Zebra clams to Cd treatment, suggesting that the pedigree of animal should be taken into consideration in ecotoxicology studies.
文章类型Article
资助机构National Key Basic Research Program of China [2015CB453303, 2015CB453302] ; NSFC [41676114, 41506138] ; Young Taishan Scholars Program of Shandong Province ; Qingdao National Laboratory for Marine Science and Technology [QNLM201701] ; Strategic Priority Research Program of the Chinese Academy of Science [XDA11020702] ; Youth Innovation Promotion Association CAS [2015169]
收录类别SCI
语种英语
关键词[WOS]MUSSELS MYTILUS-GALLOPROVINCIALIS ; GENDER-SPECIFIC RESPONSES ; STRESS ; BIOACCUMULATION ; ENDOCYTOSIS ; POLLUTANTS ; ORGANISMS ; INFECTION ; POLLUTION ; TOXICITY
研究领域[WOS]Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology
WOS记录号WOS:000457814500011
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/24614
专题中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
中国科学院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China;
2.Qingdao Natl Lab Marine Sci & Technol, Funct Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China;
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
4.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Shandong Prov Key Lab Fishery Resources & Ecol En, Key Lab Sustainable Dev Marine Fisheries,Minist A, Qingdao 266071, Peoples R China
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Lu, Zhen,Wang, Shuang,Shan, Xiujuan,et al. Differential biological effects in two pedigrees of clam Ruditapes philippinarum exposed to cadmium using iTRAQ-based proteomics[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2019,65:66-72.
APA Lu, Zhen,Wang, Shuang,Shan, Xiujuan,Ji, Chenglong,&Wu, Huifeng.(2019).Differential biological effects in two pedigrees of clam Ruditapes philippinarum exposed to cadmium using iTRAQ-based proteomics.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,65,66-72.
MLA Lu, Zhen,et al."Differential biological effects in two pedigrees of clam Ruditapes philippinarum exposed to cadmium using iTRAQ-based proteomics".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 65(2019):66-72.
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