| Synthesis of inulin derivatives with quaternary phosphonium salts and their antifungal activity | |
Chen, Yuan; Tan, Wenqiang ; Li, Qing; Dong, Fang; Gu, Guodong; Guo, Zhanyong
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| Source Publication | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| ISSN | 0141-8130 |
| 2018-07-01 | |
| Volume | 113Pages:1273-1278 |
| Keyword | Inulin Quaternary phosphonium salt Antifungal activity |
| MOST Discipline Catalogue | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| DOI | 10.1016/j.ijbiomac.2018.03.055 |
| Contribution Rank | [Chen, Yuan; Tan, Wenqiang; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Chen, Yuan; Tan, Wenqiang; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA |
| Department | 海岸带生物资源高效利用研究与发展中心 |
| Abstract | Inulin is a kind of renewable and biodegradable carbohydrate with good water solubility and numerous physiological functions. For further utilization of inulin, chemical modification can be applied to improve its bio-activities. In this paper, five novel inulin derivatives were synthesized via chemical modification with quaternary phosphonium salt. Their antifungal activity against three kinds of plant pathogens including Colletotrichum lagenarium, Phomopsis asparagi, and Fusarium oxysporum was assessed with radial growth assay in vitro. Results revealed that all the inulin derivatives exhibited improved antifungal activity compared with inulin. Particularly, inulin modified with triphenylphosphine (TPhPAIL) exhibited the best antifungal activity with inhibitory indices of 80.0%, 78.8%, and 87.4% against Colletotrichum lagenarium, Phomopsis asparagi, and Fusarium oxysporum at 1.0 mg/mL respectively. The results clearly showed that chemical modification of inulin with quaternary phosphonium salt could efficiently improve derivatives' antifungal activity. Further analysis of results indicated that the antifungal activity was influenced by alkyl chain length or electron-withdrawing ability of the grafted quaternary phosphonium salts. Longer alkyl chain lengths or the stronger electron-withdrawing groups would lead to enhanced antifungal efficacy. |
| Subtype | Article |
| Funding Organization | National Natural Science Foundation of China [41576156] ; Shandong Province Science and Technology Development Plan [2015GSF121045] ; Yantai Science and Technology Development Plan [2015ZH078] ; Public Science and Technology Research Funds Projects of Ocean [201505022-3] |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | ANTIBACTERIAL ACTIVITY ; CARBOXYMETHYL CELLULOSE ; CHITOSAN ; FRUCTANS ; BIOMATERIALS ; SUBSTITUTION ; SPECTROSCOPY ; PRODUCTS ; BENEFITS ; RUBBER |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science |
| WOS ID | WOS:000432503100145 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.yic.ac.cn/handle/133337/24448 |
| Collection | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 |
| Affiliation | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA |
| Recommended Citation GB/T 7714 | Chen, Yuan,Tan, Wenqiang,Li, Qing,et al. Synthesis of inulin derivatives with quaternary phosphonium salts and their antifungal activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,113:1273-1278. |
| APA | Chen, Yuan,Tan, Wenqiang,Li, Qing,Dong, Fang,Gu, Guodong,&Guo, Zhanyong.(2018).Synthesis of inulin derivatives with quaternary phosphonium salts and their antifungal activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,113,1273-1278. |
| MLA | Chen, Yuan,et al."Synthesis of inulin derivatives with quaternary phosphonium salts and their antifungal activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 113(2018):1273-1278. |
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| Synthesis of inulin （1246KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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