Synthesis of inulin derivatives with quaternary phosphonium salts and their antifungal activity
Chen, Yuan; Tan, Wenqiang; Li, Qing; Dong, Fang; Gu, Guodong; Guo, Zhanyong
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
2018-07-01
Volume113Pages:1273-1278
KeywordInulin Quaternary phosphonium salt Antifungal activity
MOST Discipline CatalogueBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
DOI10.1016/j.ijbiomac.2018.03.055
Contribution Rank[Chen, Yuan; Tan, Wenqiang; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Chen, Yuan; Tan, Wenqiang; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
Department海岸带生物资源高效利用研究与发展中心
AbstractInulin is a kind of renewable and biodegradable carbohydrate with good water solubility and numerous physiological functions. For further utilization of inulin, chemical modification can be applied to improve its bio-activities. In this paper, five novel inulin derivatives were synthesized via chemical modification with quaternary phosphonium salt. Their antifungal activity against three kinds of plant pathogens including Colletotrichum lagenarium, Phomopsis asparagi, and Fusarium oxysporum was assessed with radial growth assay in vitro. Results revealed that all the inulin derivatives exhibited improved antifungal activity compared with inulin. Particularly, inulin modified with triphenylphosphine (TPhPAIL) exhibited the best antifungal activity with inhibitory indices of 80.0%, 78.8%, and 87.4% against Colletotrichum lagenarium, Phomopsis asparagi, and Fusarium oxysporum at 1.0 mg/mL respectively. The results clearly showed that chemical modification of inulin with quaternary phosphonium salt could efficiently improve derivatives' antifungal activity. Further analysis of results indicated that the antifungal activity was influenced by alkyl chain length or electron-withdrawing ability of the grafted quaternary phosphonium salts. Longer alkyl chain lengths or the stronger electron-withdrawing groups would lead to enhanced antifungal efficacy.
SubtypeArticle
Funding OrganizationNational Natural Science Foundation of China [41576156] ; Shandong Province Science and Technology Development Plan [2015GSF121045] ; Yantai Science and Technology Development Plan [2015ZH078] ; Public Science and Technology Research Funds Projects of Ocean [201505022-3]
Indexed BySCI
Language英语
WOS KeywordANTIBACTERIAL ACTIVITY ; CARBOXYMETHYL CELLULOSE ; CHITOSAN ; FRUCTANS ; BIOMATERIALS ; SUBSTITUTION ; SPECTROSCOPY ; PRODUCTS ; BENEFITS ; RUBBER
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000432503100145
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/24448
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
3.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
Recommended Citation
GB/T 7714
Chen, Yuan,Tan, Wenqiang,Li, Qing,et al. Synthesis of inulin derivatives with quaternary phosphonium salts and their antifungal activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,113:1273-1278.
APA Chen, Yuan,Tan, Wenqiang,Li, Qing,Dong, Fang,Gu, Guodong,&Guo, Zhanyong.(2018).Synthesis of inulin derivatives with quaternary phosphonium salts and their antifungal activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,113,1273-1278.
MLA Chen, Yuan,et al."Synthesis of inulin derivatives with quaternary phosphonium salts and their antifungal activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 113(2018):1273-1278.
Files in This Item:
File Name/Size DocType Version Access License
Synthesis of inulin (1246KB)期刊论文出版稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen, Yuan]'s Articles
[Tan, Wenqiang]'s Articles
[Li, Qing]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen, Yuan]'s Articles
[Tan, Wenqiang]'s Articles
[Li, Qing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen, Yuan]'s Articles
[Tan, Wenqiang]'s Articles
[Li, Qing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Synthesis of inulin derivatives with quaternary phosphonium salts and their antifungal activity.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.