Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis
Wu, Huifeng; Zhong, Mingyu; Lu, Zhen; Shan, Xiujuan; Li, Fei; Ji, Chenglong; Cong, Ming
Source PublicationENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
ISSN1382-6689
2018-07
Volume61Pages:102-106
KeywordOrganophosphate flame retardants (OPFRs) Tris (2-chloropropyl) phosphate (TCPP) Biological effects InununityMytilus galloprovincialis
MOST Discipline CatalogueEnvironmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
DOI10.1016/j.etap.2018.05.022
Contribution Rank[Wu, Huifeng; Zhong, Mingyu; Lu, Zhen; Li, Fei; Ji, Chenglong; Cong, Ming] Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res,YICCAS, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China; [Wu, Huifeng; Shan, Xiujuan; Ji, Chenglong] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China; [Zhong, Mingyu; Lu, Zhen] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Department海岸带环境过程实验室
AbstractOrganophosphate flame retardants (OPFRs) are increasingly produced and used as alternatives of brominated flame-retardants (BFRs) and have become emerging marine environmental contaminants. So far, however, little is known regarding the biological effects of OPFRs in marine organisms. In this study, the biological effects of one of the most abundant OPFRs, tris (1-chloro-2-propyl) phosphate (TCPP), on the immunity in mussel Mytilus galloprovincialis were characterized by testing the reactive oxygen species, apoptosis, antioxidant system and immunity related gene expressions. Results indicated that both TCPP exposures (10 and 100 nmol L-1) significantly (p < 0.01) enhanced reactive oxygen species production and the high dose of TCPP induced more apoptosis and oxidative stress in mussel hemocytes. TCPP also induced an obvious hormesis phenomenon (low dose inhibition and high dose stimulation) in mussel hemocytes, as indicated by the gene expression profiles of caspase 8 and mytimacin. The down-regulated gene expression levels of lysozymes suggested that both TCPP exposures inhibited the innate immunity in mussel M. galloprovincialis. The significantly (p < 0.01) increased gene expression levels of TLR, galectin, PGRP and LITAF demonstrated that TCPP induced dose-dependent immune stress in mussels. Overall, this work suggested that TCPP could influence the immune system in marine mussel M. galloprovincialis.
SubtypeArticle
Indexed BySCI
Language英语
WOS KeywordORGANOPHOSPHORUS FLAME RETARDANTS ; SPATIAL-DISTRIBUTION ; SURFACE WATERS ; YELLOW SEAS ; PLASTICIZERS ; EXPRESSION ; CHINA ; BOHAI ; ACTIVATION ; RECEPTORS
WOS Research AreaEnvironmental Sciences ; Pharmacology & Pharmacy ; Toxicology
WOS IDWOS:000437960800015
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/24442
Collection中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
Affiliation1.Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res,YICCAS, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China;
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China;
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wu, Huifeng,Zhong, Mingyu,Lu, Zhen,et al. Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2018,61:102-106.
APA Wu, Huifeng.,Zhong, Mingyu.,Lu, Zhen.,Shan, Xiujuan.,Li, Fei.,...&Cong, Ming.(2018).Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,61,102-106.
MLA Wu, Huifeng,et al."Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 61(2018):102-106.
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