Peptidoglycan recognition protein of Solen grandis (SgPGRP-S1) mediates immune recognition and bacteria clearance | |
Wei, Xiumei; Yang, Dinglong; Li, Huiying; Zhao, Tianyu; Jiang, Hailin; Liu, Xiangquan; Yang, Jialong | |
发表期刊 | FISH & SHELLFISH IMMUNOLOGY |
ISSN | 1050-4648 |
2018-02 | |
卷号 | 73页码:30-36 |
关键词 | Razor clam Peptidoglycan recognition protein Immune recognition Antibacterial response Amidase |
研究领域 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
DOI | 10.1016/j.fsi.2017.12.001 |
产权排序 | [Wei, Xiumei; Li, Huiying; Zhao, Tianyu; Yang, Jialong] East China Normal Univ, Sch Life Sci, Lab Aquat Comparat Immunol, Shanghai 200241, Peoples R China; [Wei, Xiumei; Jiang, Hailin; Liu, Xiangquan] Marine Resource & Environm Res Inst, Yantai 264006, Peoples R China; [Yang, Dinglong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
作者部门 | 海岸带生物资源高效利用研究与发展中心 |
英文摘要 | Peptidoglycan recognition proteins (PGRPs) are indispensable molecules in innate immunity due to their prominent function in sensing and eliminating invading microorganisms. In the present study, a short type PGRP from razor clam Solen grandis (SgPGRP-S1) was recombinantly expressed and purified to investigate its potential function in innate immunity. As a pattern recognition receptor, recombinant SgPGRP-S1 (rSgPGRP-S1) specifically bind Lys-type and Dap-type peptidoglycan in vitro, but not lipopolysaccharide or beta-glucan. The peptidoglycan binding ability of rSgPGRP-S1 resulted in significant agglutination activity against Gram-negative Escherichia coil and Listonella anguillarum, as well as Gram-positive Micrococcus luteus. Furthemiore, rSgPGRP-S1 was bactericidal, significantly suppressing the growth of both E. coli and Gram-positive Staphylococcus aureus. The protein also exhibited strong amidase activity and degraded bacterial peptidoglycan in the presence of Zn2+, suggesting amidase activity might contribute to SgPGRP-S1 antibacterial activity. These results indicate SgPGRP-S1 is multifunctional in innate immunity, mediating both immune recognition and bacteria elimination. |
文章类型 | Article |
资助机构 | National Natural Science Foundation of China [31202025] ; Fundamental Research Funds for the Central Universities [40500-20101-222005] |
收录类别 | SCI |
语种 | 英语 |
关键词[WOS] | CARP CTENOPHARYNGODON-IDELLA ; MESSENGER-RNA EXPRESSION ; SCALLOP CHLAMYS-FARRERI ; GRAM-POSITIVE BACTERIA ; FUNCTIONAL-CHARACTERIZATION ; MOLECULAR-CLONING ; ANTIBACTERIAL DEFENSE ; MONOCLONAL-ANTIBODY ; AMIDASE ACTIVITY ; INNATE IMMUNITY |
研究领域[WOS] | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
WOS记录号 | WOS:000424853100004 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/24399 |
专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
作者单位 | 1.East China Normal Univ, Sch Life Sci, Lab Aquat Comparat Immunol, Shanghai 200241, Peoples R China; 2.Marine Resource & Environm Res Inst, Yantai 264006, Peoples R China; 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
推荐引用方式 GB/T 7714 | Wei, Xiumei,Yang, Dinglong,Li, Huiying,et al. Peptidoglycan recognition protein of Solen grandis (SgPGRP-S1) mediates immune recognition and bacteria clearance[J]. FISH & SHELLFISH IMMUNOLOGY,2018,73:30-36. |
APA | Wei, Xiumei.,Yang, Dinglong.,Li, Huiying.,Zhao, Tianyu.,Jiang, Hailin.,...&Yang, Jialong.(2018).Peptidoglycan recognition protein of Solen grandis (SgPGRP-S1) mediates immune recognition and bacteria clearance.FISH & SHELLFISH IMMUNOLOGY,73,30-36. |
MLA | Wei, Xiumei,et al."Peptidoglycan recognition protein of Solen grandis (SgPGRP-S1) mediates immune recognition and bacteria clearance".FISH & SHELLFISH IMMUNOLOGY 73(2018):30-36. |
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