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Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes
Leger, Michelle M.1,11; Kolisko, Martin1,12; Kamikawa, Ryoma2; Stairs, Courtney W.1,6; Kume, Keitaro3; Cepicka, Ivan4; Silberman, Jeffrey D.5; Andersson, Jan O.6; Xu, Feifei6; Yabuki, Akinori7; Eme, Laura1,6; Zhang, Qianqian8; Takishita, Kiyotaka7; Inagaki, Yuji3,9; Simpson, Alastair G. B.10; Hashimoto, Tetsuo3,9; Roger, Andrew J.1
2017-04-01
Source PublicationNATURE ECOLOGY & EVOLUTION
ISSN2397-334X
Volume1Issue:4
AbstractMany anaerobic microbial parasites possess highly modified mitochondria known as mitochondrion-related organelles (MROs). The best-studied of these are the hydrogenosomes of Trichomonas vaginalis and Spironucleus salmonicida, which produce ATP anaerobically through substrate-level phosphorylation with concomitant hydrogen production; and the mitosomes of Giardia intestinalis, which are functionally reduced and lack any role in ATP production. Howewer, to understand the metabolic specializations that these MROs underwent in adaptation to parasitism, data from their free-living relatives are needed. Here, we present a large-scale comparative transcriptomic study of MROs across a major eukaryotic group, Metamonada, examining lineage-specific gain and loss of metabolic functions in the MROs of Trichomonas, Giardia, Spironucleus and their free-living relatives. Our analyses uncover a complex history of ATP production machinery in diplomonads such as Giardia, and their closest relative, Dysnectes; and a correlation between the glycine cleavage machinery and lifestyles. Our data further suggest the existence of a previously undescribed biochemical class of MRO that generates hydrogen but is incapable of ATP synthesis.
DOI10.1038/s41559-017-0092
Funding OrganizationCanadian Institutes of Health Research(MOP-142349) ; JSPS Strategic Young Researcher Overseas Visits Program ; NSERC Grant(298366-2009) ; Czech Science Foundation(GA14-14105S) ; Japan Society for the Promotion of Science (JSPS)(15H05606, 15K14591, 23117005, 15H05231, 23117006)
Indexed BySCI
WOS KeywordGLYCINE DECARBOXYLASE COMPLEX ; ACETYL-COA SYNTHETASE ; TRITRICHOMONAS-FETUS ; PYRUVATE METABOLISM ; CLEAVAGE SYSTEM ; PROTEIN IMPORT ; MITOCHONDRIAL ; EVOLUTION ; VAGINALIS ; PHYLOGENIES
SubtypeArticle
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Evolutionary Biology
WOS SubjectEcology ; Evolutionary Biology
WOS IDWOS:000417171500014
PublisherNATURE PUBLISHING GROUP
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/24047
Collection海岸带生物学与生物资源保护实验室
Corresponding AuthorHashimoto, Tetsuo; Roger, Andrew J.
Affiliation1.Dalhousie Univ, Dept Biochem & Mol Biol, 5850 Coll St,POB 15000, Halifax, NS B3H 4R2, Canada
2.Kyoto Univ, Grad Sch Global Environm Studies, Grad Sch Human & Environm Studies, Sakyo Ku, Yoshida Honmachi, Kyoto 6068501, Japan
3.Univ Tsukuba, Ctr Computat Sci, Grad Sch Life & Environm Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058572, Japan
4.Charles Univ Prague, Fac Sci, Dept Zool, Vinicna 7, CR-12844 Prague 2, Czech Republic
5.Univ Arkansas, Dept Biol Sci, Fayetteville, AR 72701 USA
6.Uppsala Univ, Dept Cell & Mol Biol, Box 596, S-75124 Uppsala, Sweden
7.Japan Agcy Marine Earth Sci & Technol JAMSTEC, 2-15 Natsushima Cho, Yokosuka, Kanagawa 2370061, Japan
8.Chinese Acad Sci, Yantai Inst Coastal Zone Res, 17 Chunhui Rd, Yantai 264003, Shandong, Peoples R China
9.Univ Tsukuba, Ctr Computat Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058577, Japan
10.Dalhousie Univ, Dept Biol, 1355 Oxford St,POB 15000, Halifax, NS B3H 4R2, Canada
11.Univ Pompeu Fabra, CSIC, Inst Evolutionary Biol, Passeig Maritim de la Barceloneta 37-49, Barcelona 08003, Spain
12.Czech Acad Sci, Biol Ctr, Inst Parasitol, Branisovska 1160-31, Ceske Budejovice 37005, Czech Republic
Recommended Citation
GB/T 7714
Leger, Michelle M.,Kolisko, Martin,Kamikawa, Ryoma,et al. Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes[J]. NATURE ECOLOGY & EVOLUTION,2017,1(4).
APA Leger, Michelle M..,Kolisko, Martin.,Kamikawa, Ryoma.,Stairs, Courtney W..,Kume, Keitaro.,...&Roger, Andrew J..(2017).Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes.NATURE ECOLOGY & EVOLUTION,1(4).
MLA Leger, Michelle M.,et al."Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes".NATURE ECOLOGY & EVOLUTION 1.4(2017).
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