| Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes | |
Leger, Michelle M.1,11; Kolisko, Martin1,12; Kamikawa, Ryoma2; Stairs, Courtney W.1,6; Kume, Keitaro3; Cepicka, Ivan4; Silberman, Jeffrey D.5; Andersson, Jan O.6; Xu, Feifei6; Yabuki, Akinori7; Eme, Laura1,6; Zhang, Qianqian8 ; Takishita, Kiyotaka7; Inagaki, Yuji3,9; Simpson, Alastair G. B.10; Hashimoto, Tetsuo3,9; Roger, Andrew J.1
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| 发表期刊 | NATURE ECOLOGY & EVOLUTION
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| ISSN | 2397-334X |
| 2017-04-01 | |
| 卷号 | 1期号:4页码:UNSP 0092 |
| 关键词 | GLYCINE DECARBOXYLASE COMPLEX ACETYL-COA SYNTHETASE TRITRICHOMONAS-FETUS PYRUVATE METABOLISM CLEAVAGE SYSTEM PROTEIN IMPORT MITOCHONDRIAL EVOLUTION VAGINALIS PHYLOGENIES |
| 研究领域 | Ecology ; Evolutionary Biology |
| DOI | 10.1038/s41559-017-0092 |
| 产权排序 | [Leger, Michelle M.; Kolisko, Martin; Stairs, Courtney W.; Eme, Laura; Roger, Andrew J.] Dalhousie Univ, Dept Biochem & Mol Biol, 5850 Coll St,POB 15000, Halifax, NS B3H 4R2, Canada; [Kamikawa, Ryoma] Kyoto Univ, Grad Sch Global Environm Studies, Grad Sch Human & Environm Studies, Sakyo Ku, Yoshida Honmachi, Kyoto 6068501, Japan; [Kume, Keitaro; Inagaki, Yuji; Hashimoto, Tetsuo] Univ Tsukuba, Ctr Computat Sci, Grad Sch Life & Environm Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058572, Japan; [Cepicka, Ivan] Charles Univ Prague, Fac Sci, Dept Zool, Vinicna 7, CR-12844 Prague 2, Czech Republic; [Silberman, Jeffrey D.] Univ Arkansas, Dept Biol Sci, Fayetteville, AR 72701 USA; [Stairs, Courtney W.; Andersson, Jan O.; Xu, Feifei; Eme, Laura] Uppsala Univ, Dept Cell & Mol Biol, Box 596, S-75124 Uppsala, Sweden; [Yabuki, Akinori; Takishita, Kiyotaka] Japan Agcy Marine Earth Sci & Technol JAMSTEC, 2-15 Natsushima Cho, Yokosuka, Kanagawa 2370061, Japan; [Zhang, Qianqian] Chinese Acad Sci, Yantai Inst Coastal Zone Res, 17 Chunhui Rd, Yantai 264003, Shandong, Peoples R China; [Inagaki, Yuji; Hashimoto, Tetsuo] Univ Tsukuba, Ctr Computat Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058577, Japan; [Simpson, Alastair G. B.] Dalhousie Univ, Dept Biol, 1355 Oxford St,POB 15000, Halifax, NS B3H 4R2, Canada; [Leger, Michelle M.] Univ Pompeu Fabra, CSIC, Inst Evolutionary Biol, Passeig Maritim de la Barceloneta 37-49, Barcelona 08003, Spain; [Kolisko, Martin] Czech Acad Sci, Biol Ctr, Inst Parasitol, Branisovska 1160-31, Ceske Budejovice 37005, Czech Republic |
| 作者部门 | 海岸带生物资源高效利用研究与发展中心 |
| 英文摘要 | Many anaerobic microbial parasites possess highly modified mitochondria known as mitochondrion-related organelles (MROs). The best-studied of these are the hydrogenosomes of Trichomonas vaginalis and Spironucleus salmonicida, which produce ATP anaerobically through substrate-level phosphorylation with concomitant hydrogen production; and the mitosomes of Giardia intestinalis, which are functionally reduced and lack any role in ATP production. Howewer, to understand the metabolic specializations that these MROs underwent in adaptation to parasitism, data from their free-living relatives are needed. Here, we present a large-scale comparative transcriptomic study of MROs across a major eukaryotic group, Metamonada, examining lineage-specific gain and loss of metabolic functions in the MROs of Trichomonas, Giardia, Spironucleus and their free-living relatives. Our analyses uncover a complex history of ATP production machinery in diplomonads such as Giardia, and their closest relative, Dysnectes; and a correlation between the glycine cleavage machinery and lifestyles. Our data further suggest the existence of a previously undescribed biochemical class of MRO that generates hydrogen but is incapable of ATP synthesis. |
| 文章类型 | Article |
| 资助机构 | Canadian Institutes of Health Research(MOP-142349) ; JSPS Strategic Young Researcher Overseas Visits Program ; NSERC Grant(298366-2009) ; Czech Science Foundation(GA14-14105S) ; Japan Society for the Promotion of Science (JSPS)(15H05606, 15K14591, 23117005, 15H05231, 23117006) |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | GLYCINE DECARBOXYLASE COMPLEX ; ACETYL-COA SYNTHETASE ; TRITRICHOMONAS-FETUS ; PYRUVATE METABOLISM ; CLEAVAGE SYSTEM ; PROTEIN IMPORT ; MITOCHONDRIAL ; EVOLUTION ; VAGINALIS ; PHYLOGENIES |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Evolutionary Biology |
| WOS记录号 | WOS:000417171500014 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24047 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 通讯作者 | Hashimoto, Tetsuo; Roger, Andrew J. |
| 作者单位 | 1.Dalhousie Univ, Dept Biochem & Mol Biol, 5850 Coll St,POB 15000, Halifax, NS B3H 4R2, Canada 2.Kyoto Univ, Grad Sch Global Environm Studies, Grad Sch Human & Environm Studies, Sakyo Ku, Yoshida Honmachi, Kyoto 6068501, Japan 3.Univ Tsukuba, Ctr Computat Sci, Grad Sch Life & Environm Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058572, Japan 4.Charles Univ Prague, Fac Sci, Dept Zool, Vinicna 7, CR-12844 Prague 2, Czech Republic 5.Univ Arkansas, Dept Biol Sci, Fayetteville, AR 72701 USA 6.Uppsala Univ, Dept Cell & Mol Biol, Box 596, S-75124 Uppsala, Sweden 7.Japan Agcy Marine Earth Sci & Technol JAMSTEC, 2-15 Natsushima Cho, Yokosuka, Kanagawa 2370061, Japan 8.Chinese Acad Sci, Yantai Inst Coastal Zone Res, 17 Chunhui Rd, Yantai 264003, Shandong, Peoples R China 9.Univ Tsukuba, Ctr Computat Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058577, Japan 10.Dalhousie Univ, Dept Biol, 1355 Oxford St,POB 15000, Halifax, NS B3H 4R2, Canada 11.Univ Pompeu Fabra, CSIC, Inst Evolutionary Biol, Passeig Maritim de la Barceloneta 37-49, Barcelona 08003, Spain 12.Czech Acad Sci, Biol Ctr, Inst Parasitol, Branisovska 1160-31, Ceske Budejovice 37005, Czech Republic |
| 推荐引用方式 GB/T 7714 | Leger, Michelle M.,Kolisko, Martin,Kamikawa, Ryoma,et al. Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes[J]. NATURE ECOLOGY & EVOLUTION,2017,1(4):UNSP 0092. |
| APA | Leger, Michelle M..,Kolisko, Martin.,Kamikawa, Ryoma.,Stairs, Courtney W..,Kume, Keitaro.,...&Roger, Andrew J..(2017).Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes.NATURE ECOLOGY & EVOLUTION,1(4),UNSP 0092. |
| MLA | Leger, Michelle M.,et al."Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes".NATURE ECOLOGY & EVOLUTION 1.4(2017):UNSP 0092. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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