Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes
Leger, Michelle M.1,11; Kolisko, Martin1,12; Kamikawa, Ryoma2; Stairs, Courtney W.1,6; Kume, Keitaro3; Cepicka, Ivan4; Silberman, Jeffrey D.5; Andersson, Jan O.6; Xu, Feifei6; Yabuki, Akinori7; Eme, Laura1,6; Zhang, Qianqian8; Takishita, Kiyotaka7; Inagaki, Yuji3,9; Simpson, Alastair G. B.10; Hashimoto, Tetsuo3,9; Roger, Andrew J.1
2017-04-01
发表期刊NATURE ECOLOGY & EVOLUTION
ISSN2397-334X
卷号1期号:4
摘要Many anaerobic microbial parasites possess highly modified mitochondria known as mitochondrion-related organelles (MROs). The best-studied of these are the hydrogenosomes of Trichomonas vaginalis and Spironucleus salmonicida, which produce ATP anaerobically through substrate-level phosphorylation with concomitant hydrogen production; and the mitosomes of Giardia intestinalis, which are functionally reduced and lack any role in ATP production. Howewer, to understand the metabolic specializations that these MROs underwent in adaptation to parasitism, data from their free-living relatives are needed. Here, we present a large-scale comparative transcriptomic study of MROs across a major eukaryotic group, Metamonada, examining lineage-specific gain and loss of metabolic functions in the MROs of Trichomonas, Giardia, Spironucleus and their free-living relatives. Our analyses uncover a complex history of ATP production machinery in diplomonads such as Giardia, and their closest relative, Dysnectes; and a correlation between the glycine cleavage machinery and lifestyles. Our data further suggest the existence of a previously undescribed biochemical class of MRO that generates hydrogen but is incapable of ATP synthesis.
DOI10.1038/s41559-017-0092
项目资助者Canadian Institutes of Health Research(MOP-142349) ; JSPS Strategic Young Researcher Overseas Visits Program ; NSERC Grant(298366-2009) ; Czech Science Foundation(GA14-14105S) ; Japan Society for the Promotion of Science (JSPS)(15H05606, 15K14591, 23117005, 15H05231, 23117006)
收录类别SCI
关键词[WOS]GLYCINE DECARBOXYLASE COMPLEX ; ACETYL-COA SYNTHETASE ; TRITRICHOMONAS-FETUS ; PYRUVATE METABOLISM ; CLEAVAGE SYSTEM ; PROTEIN IMPORT ; MITOCHONDRIAL ; EVOLUTION ; VAGINALIS ; PHYLOGENIES
文章类型Article
语种英语
WOS研究方向Environmental Sciences & Ecology ; Evolutionary Biology
WOS类目Ecology ; Evolutionary Biology
WOS记录号WOS:000417171500014
出版者NATURE PUBLISHING GROUP
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/24047
专题海岸带生物学与生物资源利用所重点实验室
通讯作者Hashimoto, Tetsuo; Roger, Andrew J.
作者单位1.Dalhousie Univ, Dept Biochem & Mol Biol, 5850 Coll St,POB 15000, Halifax, NS B3H 4R2, Canada
2.Kyoto Univ, Grad Sch Global Environm Studies, Grad Sch Human & Environm Studies, Sakyo Ku, Yoshida Honmachi, Kyoto 6068501, Japan
3.Univ Tsukuba, Ctr Computat Sci, Grad Sch Life & Environm Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058572, Japan
4.Charles Univ Prague, Fac Sci, Dept Zool, Vinicna 7, CR-12844 Prague 2, Czech Republic
5.Univ Arkansas, Dept Biol Sci, Fayetteville, AR 72701 USA
6.Uppsala Univ, Dept Cell & Mol Biol, Box 596, S-75124 Uppsala, Sweden
7.Japan Agcy Marine Earth Sci & Technol JAMSTEC, 2-15 Natsushima Cho, Yokosuka, Kanagawa 2370061, Japan
8.Chinese Acad Sci, Yantai Inst Coastal Zone Res, 17 Chunhui Rd, Yantai 264003, Shandong, Peoples R China
9.Univ Tsukuba, Ctr Computat Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058577, Japan
10.Dalhousie Univ, Dept Biol, 1355 Oxford St,POB 15000, Halifax, NS B3H 4R2, Canada
11.Univ Pompeu Fabra, CSIC, Inst Evolutionary Biol, Passeig Maritim de la Barceloneta 37-49, Barcelona 08003, Spain
12.Czech Acad Sci, Biol Ctr, Inst Parasitol, Branisovska 1160-31, Ceske Budejovice 37005, Czech Republic
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Leger, Michelle M.,Kolisko, Martin,Kamikawa, Ryoma,et al. Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes[J]. NATURE ECOLOGY & EVOLUTION,2017,1(4).
APA Leger, Michelle M..,Kolisko, Martin.,Kamikawa, Ryoma.,Stairs, Courtney W..,Kume, Keitaro.,...&Roger, Andrew J..(2017).Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes.NATURE ECOLOGY & EVOLUTION,1(4).
MLA Leger, Michelle M.,et al."Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes".NATURE ECOLOGY & EVOLUTION 1.4(2017).
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