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Toxic responses of Perna viridis hepatopancreas exposed to DDT, benzo(a) pyrene and their mixture uncovered by iTRAQ-based proteomics and NMR-based metabolomics
Song, Qinqin1,2,3; Zhou, Hailong1,2; Han, Qian1,2; Diao, Xiaoping1,2
2017-11-01
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
Volume192Pages:48-57
AbstractDichlorodiphenyltrichloroethane (DDT) and benzo(a)pyrene (BaP) are environmental estrogens (EEs) that are ubiquitous in the marine environment. In the present study, we integrated isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic and nuclear magnetic resonance (NMR)-based metabolomic approaches to explore the toxic responses of green mussel hepatopancreas exposed to DDT (10 mu g/L), BaP (10 mu g/L) and their mixture. The metabolic responses indicated that BaP primarily disturbed energy metabolism and osmotic regulation in the hepatopancreas of the male green mussel P. viridis. Both DDT and the mixture of DDT and BaP perturbed the energy metabolism and osmotic regulation in P. viridis. The proteomic responses revealed that BaP affected the proteins involved in energy metabolism, material transformation, cytoskeleton, stress responses, reproduction and development in green mussels. DDT exposure could change the proteins involved in primary metabolism, stress responses, cytoskeleton and signal transduction. However, the mixture of DDT and BaP altered proteins associated with material and energy metabolism, stress responses, signal transduction, reproduction and development, cytoskeleton and apoptosis. This study showed that iTRAQ-based proteomic and NMR-based metabolomic approaches could effectively elucidate the essential molecular mechanism of disturbances in hepatopancreas function of green mussels exposed to environmental estrogens.
KeywordBenzo(a)Pyrene Ddt P. Viridis Hepatopancreas Itraq Metabolomics
DOI10.1016/j.aquatox.2017.09.010
Funding OrganizationNational Natural Science Foundation of China(41161077, 31760164) ; Specialized Research Fund for the Midwest Program of Hainan University(ZXBJH-XK002)
Indexed BySCI
WOS KeywordMUSSEL MYTILUS-GALLOPROVINCIALIS ; CLAM RUDITAPES-PHILIPPINARUM ; EARTHWORM EISENIA-FOETIDA ; OYSTER CRASSOSTREA-GIGAS ; HEAT-SHOCK PROTEINS ; GENDER-SPECIFIC RESPONSES ; 2,2',4,4'-TETRABROMODIPHENYL ETHER ; PETROCHEMICAL CONTAMINATION ; H-1-NMR SPECTROSCOPY ; SALINITY ACCLIMATION
SubtypeArticle
Language英语
WOS Research AreaMarine & Freshwater Biology ; Toxicology
WOS SubjectMarine & Freshwater Biology ; Toxicology
WOS IDWOS:000415768700007
PublisherELSEVIER SCIENCE BV
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/24046
Collection中科院烟台海岸带研究所知识产出
Corresponding AuthorZhou, Hailong
Affiliation1.Hainan Univ, State Key Lab Marine Resource Utilizat South Chin, Haikou 570228, Hainan, Peoples R China
2.Hainan Univ, Inst Trop Agr & Forestry, 58 Renmin Rd, Haikou 570228, Hainan, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
First Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Song, Qinqin,Zhou, Hailong,Han, Qian,et al. Toxic responses of Perna viridis hepatopancreas exposed to DDT, benzo(a) pyrene and their mixture uncovered by iTRAQ-based proteomics and NMR-based metabolomics[J]. AQUATIC TOXICOLOGY,2017,192:48-57.
APA Song, Qinqin,Zhou, Hailong,Han, Qian,&Diao, Xiaoping.(2017).Toxic responses of Perna viridis hepatopancreas exposed to DDT, benzo(a) pyrene and their mixture uncovered by iTRAQ-based proteomics and NMR-based metabolomics.AQUATIC TOXICOLOGY,192,48-57.
MLA Song, Qinqin,et al."Toxic responses of Perna viridis hepatopancreas exposed to DDT, benzo(a) pyrene and their mixture uncovered by iTRAQ-based proteomics and NMR-based metabolomics".AQUATIC TOXICOLOGY 192(2017):48-57.
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