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Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma
Zhang, Yong1; Hu, Xiaoyan1; Hu, Yue1; Teng, Kai2; Zhang, Kai1; Zheng, Yamei3; Hong, Xiaohua1; Yu, Kunwu4; Wang, Yan5; Liu, Li1
2015-02-05
发表期刊JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
ISSN1756-9966
卷号34
摘要Background: Agonistic CD40 antibodies have been demonstrated to activate antigen-presenting cells (APCs) and enhance antitumour T cell responses, thereby providing a new therapeutic option in cancer immunotherapy. In agonistic CD40 antibody-mediated inflammatory responses, a novel subset of E-cadherin + dendritic cells (DCs) has been identified, and little is known about the role of these DCs in tumour immunity. This study investigated the effect of anti-CD40-mediated inflammatory E-cadherin + DCs in murine Lewis lung carcinoma (LLC).
关键词E-cadherin Dendritic Cell t Cell Lung Cancer Activity
DOI10.1186/s13046-015-0126-9
项目资助者National Natural Science Foundations of China(81171979, 81372260) ; Doctoral fund(20110142110005)
收录类别SCI
关键词[WOS]IN-VIVO ; TUMOR-GROWTH ; LYMPH-NODES ; CANCER ; CD40 ; THERAPY ; MICE ; DIFFERENTIATION ; IMMUNOTHERAPY ; POPULATION
文章类型Article
语种英语
WOS研究方向Oncology
WOS类目Oncology
WOS记录号WOS:000350440200001
出版者BIOMED CENTRAL LTD
引用统计
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/24040
专题山东省海岸带环境工程技术研究中心
通讯作者Liu, Li
作者单位1.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Ctr Canc, Wuhan 430023, Hubei, Peoples R China
2.Hainan Canc Hosp, Haikou, Hainan, Peoples R China
3.Cent Hosp Wuhan, Dept Oncol, Wuhan, Hunan, Peoples R China
4.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Inst Cardiol,Lab Cardiovasc Immunol, Wuhan 430023, Hubei, Peoples R China
5.Chinese Acad Sci, Anal & Testing Ctr, Inst Hydro Biol, Wuhan, Peoples R China
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GB/T 7714
Zhang, Yong,Hu, Xiaoyan,Hu, Yue,et al. Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma[J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,2015,34.
APA Zhang, Yong.,Hu, Xiaoyan.,Hu, Yue.,Teng, Kai.,Zhang, Kai.,...&Liu, Li.(2015).Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma.JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,34.
MLA Zhang, Yong,et al."Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma".JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 34(2015).
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