Polyamine-Targeting Gefitinib Prodrug and its Near-Infrared Fluorescent Theranostic Derivative for Monitoring Drug Delivery and Lung Cancer Therapy
Song, Xinyu1,2; Han, Xiaoyue2,4; Yu, Fabiao2,3; Zhang, Xiaoyu1,2; Chen, Lingxin2,3; Lv, Changjun1,3
2018
发表期刊THERANOSTICS
ISSN1838-7640
卷号8期号:8页码:2217-2228
摘要The therapy of non-small-cell lung cancer (NSCLC) is challenging because of poor prognosis. There are urgent demands for targeting anti-tumor drugs with reliable efficacy and clear pharmacokinetics.
关键词Lung Cancer Drug Delivery Targeting Prodrug Fluorescence Theranostics Precision Medicine
DOI10.7150/thno.24041
项目资助者National Nature Science Foundation of China(21775162, 31470415, 81670064, 21575159, 41776110) ; program of Youth Innovation Promotion Association, CAS(2015170) ; Medical Science and Technology Development Project of Shandong Province(2017WS800) ; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, CAS(KF2016-22) ; Instrument Developing Project of the Chinese Academy of Sciences(YZ201662)
收录类别SCI
关键词[WOS]IN-VIVO ; MOLECULES ; PROBE ; EGFR ; APOPTOSIS ; CELLS ; ACTIVATION ; RESISTANCE ; EXPRESSION ; DIAGNOSIS
文章类型Article
语种英语
WOS研究方向Research & Experimental Medicine
WOS类目Medicine, Research & Experimental
WOS记录号WOS:000427107300012
出版者IVYSPRING INT PUBL
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/24027
专题中科院海岸带环境过程与生态修复重点实验室
通讯作者Yu, Fabiao; Chen, Lingxin; Lv, Changjun
作者单位1.Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
3.Binzhou Med Univ, Inst Mol Med, Med Res Ctr, Yantai 264003, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位中国科学院烟台海岸带研究所
通讯作者单位中国科学院烟台海岸带研究所
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Song, Xinyu,Han, Xiaoyue,Yu, Fabiao,et al. Polyamine-Targeting Gefitinib Prodrug and its Near-Infrared Fluorescent Theranostic Derivative for Monitoring Drug Delivery and Lung Cancer Therapy[J]. THERANOSTICS,2018,8(8):2217-2228.
APA Song, Xinyu,Han, Xiaoyue,Yu, Fabiao,Zhang, Xiaoyu,Chen, Lingxin,&Lv, Changjun.(2018).Polyamine-Targeting Gefitinib Prodrug and its Near-Infrared Fluorescent Theranostic Derivative for Monitoring Drug Delivery and Lung Cancer Therapy.THERANOSTICS,8(8),2217-2228.
MLA Song, Xinyu,et al."Polyamine-Targeting Gefitinib Prodrug and its Near-Infrared Fluorescent Theranostic Derivative for Monitoring Drug Delivery and Lung Cancer Therapy".THERANOSTICS 8.8(2018):2217-2228.
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