YIC-IR  > 中科院海岸带环境过程与生态修复重点实验室
Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells
Li, Fei1; Wang, Li3,4; Ji, Chenglong1; Wu, Huifeng1,2; Zhao, Jianmin1; Tang, Jianhui1; Wu, Huifeng(Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China)
2017-11-01
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume187Pages:88-96
Contribution Rank第1完成单位
AbstractOrganophosphate flame retardants (OPFRs) are widely used as flame retardants which are ubiquitous in various environment media. As many of OPFRs are toxic and persistent, concerns have been raised in regards to their environmental impact. In this study, the toxicological effects of tris(2-chloropropyl) phosphate (TCPP) in human L02 cells was investigated by cell proliferation and apoptosis, oxidative stress, metabolomic and proteomic responses as well as gene expressions related to apoptosis. Results showed that TCPP did not significantly affect the L02 cell apoptosis, however, a significant increase of ROS production was observed in L02 cells with TCPP treatment compared with that in control group (p < 0.05). The expression levels of Bcl-2 family-encoding genes (Bax, Hrk and Bax/Bcl-2) were up regulated significantly in 10(-4) M group (p < 0.05). Metabolomic and proteomic responses indicated that TCPP mainly caused disturbance in cell growth/division and gene expression, energy and material metabolism, signal transduction, defense and cytoskeleton, which was further confirmed by the western blot analysis. (C) 2017 Elsevier Ltd. All rights reserved.
KeywordTris(2-chloropropyl) Phosphate (Tcpp) L02 Cells Cell Apoptosis Ros Metabolomics Proteomics
DOI10.1016/j.chemosphere.2017.08.083
Funding OrganizationNational Natural Science Foundation of China(41530642, 21677173) ; Youth Innovation Promotion Association CAS(2017255) ; Chinese Academy of Sciences(KZZD-EW-14, XDA11020305)
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Indexed BySCI
WOS KeywordORGANOPHOSPHORUS FLAME RETARDANTS ; LASER-DESORPTION/IONIZATION-TIME ; IN-VITRO ; PROTEIN EXPRESSION ; GENE-EXPRESSION ; SURFACE WATERS ; PLASTICIZERS ; METABOLOMICS ; PROTEOMICS ; TOXICITY
SubtypeArticle
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS IDWOS:000412618900011
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Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/23459
Collection中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorWu, Huifeng; Wu, Huifeng(Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China)
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China
3.Yantai Yuhuangding Hosp, Dept Integrated Tradit, Yuhuangdingdong Rd 20, Yantai 264000, Shandong, Peoples R China
4.Yantai Yuhuangding Hosp, Dept Western Med, Yuhuangdingdong Rd 20, Yantai 264000, Shandong, Peoples R China
First Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
Corresponding Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Fei,Wang, Li,Ji, Chenglong,et al. Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells[J]. CHEMOSPHERE,2017,187:88-96.
APA Li, Fei.,Wang, Li.,Ji, Chenglong.,Wu, Huifeng.,Zhao, Jianmin.,...&Wu, Huifeng.(2017).Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells.CHEMOSPHERE,187,88-96.
MLA Li, Fei,et al."Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells".CHEMOSPHERE 187(2017):88-96.
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