Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells
Li, Fei1; Wang, Li3,4; Ji, Chenglong1; Wu, Huifeng1,2; Zhao, Jianmin1; Tang, Jianhui1; Wu, Huifeng(Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China)
2017-11-01
发表期刊CHEMOSPHERE
ISSN0045-6535
卷号187页码:88-96
产权排序第1完成单位
摘要Organophosphate flame retardants (OPFRs) are widely used as flame retardants which are ubiquitous in various environment media. As many of OPFRs are toxic and persistent, concerns have been raised in regards to their environmental impact. In this study, the toxicological effects of tris(2-chloropropyl) phosphate (TCPP) in human L02 cells was investigated by cell proliferation and apoptosis, oxidative stress, metabolomic and proteomic responses as well as gene expressions related to apoptosis. Results showed that TCPP did not significantly affect the L02 cell apoptosis, however, a significant increase of ROS production was observed in L02 cells with TCPP treatment compared with that in control group (p < 0.05). The expression levels of Bcl-2 family-encoding genes (Bax, Hrk and Bax/Bcl-2) were up regulated significantly in 10(-4) M group (p < 0.05). Metabolomic and proteomic responses indicated that TCPP mainly caused disturbance in cell growth/division and gene expression, energy and material metabolism, signal transduction, defense and cytoskeleton, which was further confirmed by the western blot analysis. (C) 2017 Elsevier Ltd. All rights reserved.
关键词Tris(2-chloropropyl) Phosphate (Tcpp) L02 Cells Cell Apoptosis Ros Metabolomics Proteomics
DOI10.1016/j.chemosphere.2017.08.083
项目资助者National Natural Science Foundation of China(41530642, 21677173) ; Youth Innovation Promotion Association CAS(2017255) ; Chinese Academy of Sciences(KZZD-EW-14, XDA11020305)
URL查看原文
收录类别SCI
关键词[WOS]ORGANOPHOSPHORUS FLAME RETARDANTS ; LASER-DESORPTION/IONIZATION-TIME ; IN-VITRO ; PROTEIN EXPRESSION ; GENE-EXPRESSION ; SURFACE WATERS ; PLASTICIZERS ; METABOLOMICS ; PROTEOMICS ; TOXICITY
文章类型Article
语种英语
WOS研究方向Environmental Sciences & Ecology
WOS记录号WOS:000412618900011
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/23459
专题中科院海岸带环境过程与生态修复重点实验室
通讯作者Wu, Huifeng; Wu, Huifeng(Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China)
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China
3.Yantai Yuhuangding Hosp, Dept Integrated Tradit, Yuhuangdingdong Rd 20, Yantai 264000, Shandong, Peoples R China
4.Yantai Yuhuangding Hosp, Dept Western Med, Yuhuangdingdong Rd 20, Yantai 264000, Shandong, Peoples R China
第一作者单位中国科学院烟台海岸带研究所
通讯作者单位中国科学院烟台海岸带研究所
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GB/T 7714
Li, Fei,Wang, Li,Ji, Chenglong,et al. Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells[J]. CHEMOSPHERE,2017,187:88-96.
APA Li, Fei.,Wang, Li.,Ji, Chenglong.,Wu, Huifeng.,Zhao, Jianmin.,...&Wu, Huifeng.(2017).Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells.CHEMOSPHERE,187,88-96.
MLA Li, Fei,et al."Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells".CHEMOSPHERE 187(2017):88-96.
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