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题名:
Preparation and Characterization of Novel Cationic Chitosan Derivatives Bearing Quaternary Ammonium and Phosphonium Salts and Assessment of Their Antifungal Properties
作者: Tan, Wenqiang1,2; Li, Qing1; Dong, Fang1; Chen, Qiuhong1; Guo, Zhanyong1,2
刊名: MOLECULES
ISSN号: 1420-3049
出版日期: 2017-09-01
卷号: 22, 期号:9
关键词: cationic chitosan derivatives ; quaternary ammonium salts ; quaternary phosphonium salts ; antifungal activity ; electron-withdrawing ability
DOI: 10.3390/molecules22091438
产权排序: 第1完成单位
通讯作者: Guo, Zhanyong(Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China)
英文摘要: Chitosan is an abundant and renewable polysaccharide, its derivatives exhibit attractive bioactivities and the wide applications in various biomedical fields. In this paper, two novel cationic chitosan derivatives modified with quaternary phosphonium salts were successfully synthesized via trimethylation, chloride acetylation, and quaternization with tricyclohexylphosphine and triphenylphosphine. The structures and properties of synthesized products in the reactions were characterized by FTIR spectroscopy, H-1-NMR, P-31-NMR, elemental and thermogravimetric analysis. The antifungal activities of chitosan derivatives against four kinds of phytopathogens, including Phomopsis asparagi, Watermelon fusarium, Colletotrichum lagenarium, and Fusarium oxysporum were tested using the radial growth assay in vitro. The results revealed that the synthesized cationic chitosan derivatives showed significantly improved antifungal efficiency compared to chitosan. It was reasonably suggested that quaternary phosphonium groups enabled the obviously stronger antifungal activity of the synthesized chitosans. Especially, the triphenylphosphonium-functionalized chitosan derivative inhibited the growth of Phomopsis asparagi most effectively, with inhibitory indices of about 80% at 0.5 mg/mL. Moreover, the data demonstrated that the substituted groups with stronger electron-withdrawing ability relatively possessed greater antifungal activity. The results suggest the possibility that cationic chitosan derivatives bearing quaternary phosphonium salts could be effectively employed as novel antifungal biomaterials for application in the field of agriculture.
研究领域[WOS]: Chemistry
项目资助者: National Natural Science Foundation of China(41576156) ; National key research and development program-China(2016YFF0202304) ; Shandong Province Science and Technology Development Plan(2015GSF121045) ; Yantai Science and Technology Development Plan(2015ZH078) ; Public Science and Technology Research Funds Projects of Ocean(201505022-3)
关键词[WOS]: ENHANCED WATER-SOLUBILITY ; ANTIBACTERIAL ACTIVITY ; CARBOXYMETHYL CHITOSAN ; ANTIMICROBIAL ACTIVITY ; CYTOTOXICITY ; COPOLYMERS ; DELIVERY ; DESIGN ; AGENTS
文章类型: Article
收录类别: SCI
原文出处: 查看原文
语种: 英语
WOS记录号: WOS:000411499400044
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内容类型: 期刊论文
URI标识: http://ir.yic.ac.cn/handle/133337/23455
Appears in Collections:海岸带生物学与生物资源利用所重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Tan, Wenqiang,Li, Qing,Dong, Fang,et al. Preparation and Characterization of Novel Cationic Chitosan Derivatives Bearing Quaternary Ammonium and Phosphonium Salts and Assessment of Their Antifungal Properties[J]. MOLECULES,2017,22(9).
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