Novel 1,2,3-triazolium-functionalized inulin derivatives: synthesis, free radical-scavenging activity, and antifungal activity
Li, Qing1; Qiu, Lishushi2; Tan, Wenqiang1,3; Gu, Guodong4; Guo, Zhanyong1; Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China)
2017
发表期刊RSC ADVANCES
ISSN2046-2069
卷号7期号:67页码:42225-42232
产权排序第1完成单位
摘要A new class of inulin derivatives possessing 1,2,3-triazolium charged units by associating "click reaction" with efficient 1,2,3-triazole quaternization were designed and synthesized. After the chemical modification, all the inulin derivatives showed good solubility in water, and exhibited excellent bioactivity compared to inulin. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, the scavenging activity of 1,2,3-triazolium inulin derivatives (5a-5d) (IC50 0.21-0.29 mg mL(-1)) was found to be higher than that of inulin derivatives (4a-4d) (IC50 0.58-0.95 mg mL(-1)) and inulin. 5a-5d (IC50 < 0.01 mg mL(-1)) also exhibited stronger inhibitory activity against superoxide anion formation than 4a-4d (IC50 0.02-0.09 m g mL(-1)) and Vitamin C (IC50 0.02 mg mL(-1)). In the antifungal assays, 5a-5d also inhibited the growth of tested phytopathogens more effectively with inhibitory indices of 43.10-82.56% at 1.0 mg mL(-1), compared with 4a-4d and inulin. Based on these data, it is reasonable to propose that the introduction of 1,2,3-triazolium group through chemical modification is significant to enhance the free radical-scavenging activity and antifungal activity of inulin.
DOI10.1039/c7ra08244d
项目资助者National Natural Science Foundation of China(41576156) ; Shandong Province Science and Technology Development Plan(2015GSF121045, ZR2017BD015) ; Yantai Science and Technology Development Plan(2015ZH078) ; Technology Research Funds Projects of Ocean(2015050223)
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收录类别SCI
关键词[WOS]ANTIBACTERIAL ACTIVITY ; CHITOSAN DERIVATIVES ; ANTIOXIDANT ; 1,2,4-TRIAZOLES ; INHIBITORS ; DESIGN ; POLYSACCHARIDES ; SALTS
文章类型Article
语种英语
WOS研究方向Chemistry
WOS记录号WOS:000409147500033
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/23425
专题海岸带生物学与生物资源利用所重点实验室
通讯作者Guo, Zhanyong; Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China)
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China
2.Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
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GB/T 7714
Li, Qing,Qiu, Lishushi,Tan, Wenqiang,et al. Novel 1,2,3-triazolium-functionalized inulin derivatives: synthesis, free radical-scavenging activity, and antifungal activity[J]. RSC ADVANCES,2017,7(67):42225-42232.
APA Li, Qing,Qiu, Lishushi,Tan, Wenqiang,Gu, Guodong,Guo, Zhanyong,&Guo, Zhanyong.(2017).Novel 1,2,3-triazolium-functionalized inulin derivatives: synthesis, free radical-scavenging activity, and antifungal activity.RSC ADVANCES,7(67),42225-42232.
MLA Li, Qing,et al."Novel 1,2,3-triazolium-functionalized inulin derivatives: synthesis, free radical-scavenging activity, and antifungal activity".RSC ADVANCES 7.67(2017):42225-42232.
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