Novel 1,2,3-triazolium-functionalized inulin derivatives: synthesis, free radical-scavenging activity, and antifungal activity

doi:10.1039/c7ra08244d

YIC-IR > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物学与生物资源保护实验室

	Novel 1,2,3-triazolium-functionalized inulin derivatives: synthesis, free radical-scavenging activity, and antifungal activity
	Li, Qing1 ; Qiu, Lishushi 2; Tan, Wenqiang1,3 ; Gu, Guodong 4; Guo, Zhanyong1 ; Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China)
发表期刊	RSC ADVANCES
ISSN	2046-2069
	2017
卷号	7 期号:67 页码:42225-42232
关键词	ANTIBACTERIAL ACTIVITY CHITOSAN DERIVATIVES ANTIOXIDANT 1,2,4-TRIAZOLES INHIBITORS DESIGN POLYSACCHARIDES SALTS
研究领域	Chemistry, Multidisciplinary
DOI	10.1039/c7ra08244d
产权排序	第1完成单位
作者部门	海岸带生物资源高效利用研究与发展中心
英文摘要	A new class of inulin derivatives possessing 1,2,3-triazolium charged units by associating "click reaction" with efficient 1,2,3-triazole quaternization were designed and synthesized. After the chemical modification, all the inulin derivatives showed good solubility in water, and exhibited excellent bioactivity compared to inulin. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, the scavenging activity of 1,2,3-triazolium inulin derivatives (5a-5d) (IC50 0.21-0.29 mg mL(-1)) was found to be higher than that of inulin derivatives (4a-4d) (IC50 0.58-0.95 mg mL(-1)) and inulin. 5a-5d (IC50 < 0.01 mg mL(-1)) also exhibited stronger inhibitory activity against superoxide anion formation than 4a-4d (IC50 0.02-0.09 m g mL(-1)) and Vitamin C (IC50 0.02 mg mL(-1)). In the antifungal assays, 5a-5d also inhibited the growth of tested phytopathogens more effectively with inhibitory indices of 43.10-82.56% at 1.0 mg mL(-1), compared with 4a-4d and inulin. Based on these data, it is reasonable to propose that the introduction of 1,2,3-triazolium group through chemical modification is significant to enhance the free radical-scavenging activity and antifungal activity of inulin.
文章类型	Article
资助机构	National Natural Science Foundation of China(41576156) ; Shandong Province Science and Technology Development Plan(2015GSF121045, ZR2017BD015) ; Yantai Science and Technology Development Plan(2015ZH078) ; Technology Research Funds Projects of Ocean(2015050223)
收录类别	SCI
语种	英语
关键词[WOS]	ANTIBACTERIAL ACTIVITY ; CHITOSAN DERIVATIVES ; ANTIOXIDANT ; 1,2,4-TRIAZOLES ; INHIBITORS ; DESIGN ; POLYSACCHARIDES ; SALTS
研究领域[WOS]	Chemistry
WOS记录号	WOS:000409147500033
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/23425
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Guo, Zhanyong; Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China)
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China 2.Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
推荐引用方式 GB/T 7714	Li, Qing,Qiu, Lishushi,Tan, Wenqiang,et al. Novel 1,2,3-triazolium-functionalized inulin derivatives: synthesis, free radical-scavenging activity, and antifungal activity[J]. RSC ADVANCES,2017,7(67):42225-42232.
APA	Li, Qing,Qiu, Lishushi,Tan, Wenqiang,Gu, Guodong,Guo, Zhanyong,&Guo, Zhanyong.(2017).Novel 1,2,3-triazolium-functionalized inulin derivatives: synthesis, free radical-scavenging activity, and antifungal activity.RSC ADVANCES,7(67),42225-42232.
MLA	Li, Qing,et al."Novel 1,2,3-triazolium-functionalized inulin derivatives: synthesis, free radical-scavenging activity, and antifungal activity".RSC ADVANCES 7.67(2017):42225-42232.