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Design, synthesis of novel chitosan derivatives bearing quaternary phosphonium salts and evaluation of antifungal activity
作者: Tan, Wenqiang1,2; Zhang, Jingjing1,2; Luan, Fang1,2; Wei, Lijie1,2; Chen, Yuan3; Dong, Fang1; Li, Qing1; Guo, Zhanyong1,2
刊名: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN号: 0141-8130
出版日期: 2017-09-01
卷号: 102, 页码:704-711
关键词: Chitosan derivatives ; Quaternary phosphonium salts ; Functional ; Antifungal activity ; Electron-withdrawing ability
DOI: 10.1016/j.ijbiomac.2017.04.073
产权排序: 第1完成单位
通讯作者: Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China)
英文摘要: Two novel chitosan derivatives modified with quaternary phosphonium salts were successfully synthesized, including tricyclohexylphosphonium acetyl chitosan chloride (TCPACSC) and triphenylphosphonium acetyl chitosan chloride (TPPACSC), and characterized by FTIR, H-1 NMR, and C-13 NMR spectra. The degree of substitution was also calculated by elemental analysis results. Their antifungal activities against Colletotrichum lagenarium, Watermelon fusarium, and Fusarium oxysporum were investigated in vitro using the radial growth assay, minimal inhibitory concentration, and minimum bactericidal concentration assay. The fungicidal assessment revealed that the synthesized chitosan derivatives had superior antifungal activity compared with chitosan. Especially, TPPACSC exhibited the best antifungal property with inhibitory indices of over 75% at 1.0 mg/mL. The results obviously showed that quaternary phosphonium groups could effectively enhance antifungal activity of the synthesized chitosan derivatives. Meanwhile, it was also found that their antifungal activity was influenced by electron-withdrawing ability of the quaternary phosphonium salts. The synthetic strategy described here could be utilized for the development of chitosan as antifungal biomaterials. (C) 2017 Elsevier B.V. All rights reserved.
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
项目资助者: National Natural Science Foundation of China(41576156) ; Shandong Province Science and Technology Development Plan(2015GSF121045) ; Yantai Science and Technology Development Plan(2015ZH078) ; Public Science and Technology Research Funds Projects of Ocean(201505022-3)
关键词[WOS]: ANTIBACTERIAL ACTIVITY ; ANTIMICROBIAL ACTIVITY ; CARBOXYMETHYL CHITOSAN ; AMMONIUM CHITOSAN ; ANTIOXIDANT ; COPOLYMERS ; HYDROGEL ; IONS
文章类型: Article
收录类别: SCI
原文出处: 查看原文
语种: 英语
WOS记录号: WOS:000406984300077
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内容类型: 期刊论文
URI标识: http://ir.yic.ac.cn/handle/133337/23415
Appears in Collections:海岸带生物学与生物资源利用所重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China

Recommended Citation:
Tan, Wenqiang,Zhang, Jingjing,Luan, Fang,et al. Design, synthesis of novel chitosan derivatives bearing quaternary phosphonium salts and evaluation of antifungal activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,102:704-711.
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