YIC-IR  > 海岸带生物学与生物资源保护实验室
Design, synthesis of novel chitosan derivatives bearing quaternary phosphonium salts and evaluation of antifungal activity
Tan, Wenqiang1,2; Zhang, Jingjing1,2; Luan, Fang1,2; Wei, Lijie1,2; Chen, Yuan3; Dong, Fang1; Li, Qing1; Guo, Zhanyong1,2; Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China)
2017-09-01
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
Volume102Pages:704-711
Contribution Rank第1完成单位
AbstractTwo novel chitosan derivatives modified with quaternary phosphonium salts were successfully synthesized, including tricyclohexylphosphonium acetyl chitosan chloride (TCPACSC) and triphenylphosphonium acetyl chitosan chloride (TPPACSC), and characterized by FTIR, H-1 NMR, and C-13 NMR spectra. The degree of substitution was also calculated by elemental analysis results. Their antifungal activities against Colletotrichum lagenarium, Watermelon fusarium, and Fusarium oxysporum were investigated in vitro using the radial growth assay, minimal inhibitory concentration, and minimum bactericidal concentration assay. The fungicidal assessment revealed that the synthesized chitosan derivatives had superior antifungal activity compared with chitosan. Especially, TPPACSC exhibited the best antifungal property with inhibitory indices of over 75% at 1.0 mg/mL. The results obviously showed that quaternary phosphonium groups could effectively enhance antifungal activity of the synthesized chitosan derivatives. Meanwhile, it was also found that their antifungal activity was influenced by electron-withdrawing ability of the quaternary phosphonium salts. The synthetic strategy described here could be utilized for the development of chitosan as antifungal biomaterials. (C) 2017 Elsevier B.V. All rights reserved.
KeywordChitosan Derivatives Quaternary Phosphonium Salts Functional Antifungal Activity Electron-withdrawing Ability
DOI10.1016/j.ijbiomac.2017.04.073
Funding OrganizationNational Natural Science Foundation of China(41576156) ; Shandong Province Science and Technology Development Plan(2015GSF121045) ; Yantai Science and Technology Development Plan(2015ZH078) ; Public Science and Technology Research Funds Projects of Ocean(201505022-3)
URL查看原文
Indexed BySCI
WOS KeywordANTIBACTERIAL ACTIVITY ; ANTIMICROBIAL ACTIVITY ; CARBOXYMETHYL CHITOSAN ; AMMONIUM CHITOSAN ; ANTIOXIDANT ; COPOLYMERS ; HYDROGEL ; IONS
SubtypeArticle
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS IDWOS:000406984300077
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/23415
Collection海岸带生物学与生物资源保护实验室
Corresponding AuthorGuo, Zhanyong; Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China)
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China
First Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
Corresponding Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Tan, Wenqiang,Zhang, Jingjing,Luan, Fang,et al. Design, synthesis of novel chitosan derivatives bearing quaternary phosphonium salts and evaluation of antifungal activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,102:704-711.
APA Tan, Wenqiang.,Zhang, Jingjing.,Luan, Fang.,Wei, Lijie.,Chen, Yuan.,...&Guo, Zhanyong.(2017).Design, synthesis of novel chitosan derivatives bearing quaternary phosphonium salts and evaluation of antifungal activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,102,704-711.
MLA Tan, Wenqiang,et al."Design, synthesis of novel chitosan derivatives bearing quaternary phosphonium salts and evaluation of antifungal activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 102(2017):704-711.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Tan, Wenqiang]'s Articles
[Zhang, Jingjing]'s Articles
[Luan, Fang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Tan, Wenqiang]'s Articles
[Zhang, Jingjing]'s Articles
[Luan, Fang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Tan, Wenqiang]'s Articles
[Zhang, Jingjing]'s Articles
[Luan, Fang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.