Design, synthesis of novel chitosan derivatives bearing quaternary phosphonium salts and evaluation of antifungal activity
Tan, Wenqiang1,2; Zhang, Jingjing1,2; Luan, Fang1,2; Wei, Lijie1,2; Chen, Yuan3; Dong, Fang1; Li, Qing1; Guo, Zhanyong1,2; Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China)
2017-09-01
发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
卷号102页码:704-711
产权排序第1完成单位
摘要Two novel chitosan derivatives modified with quaternary phosphonium salts were successfully synthesized, including tricyclohexylphosphonium acetyl chitosan chloride (TCPACSC) and triphenylphosphonium acetyl chitosan chloride (TPPACSC), and characterized by FTIR, H-1 NMR, and C-13 NMR spectra. The degree of substitution was also calculated by elemental analysis results. Their antifungal activities against Colletotrichum lagenarium, Watermelon fusarium, and Fusarium oxysporum were investigated in vitro using the radial growth assay, minimal inhibitory concentration, and minimum bactericidal concentration assay. The fungicidal assessment revealed that the synthesized chitosan derivatives had superior antifungal activity compared with chitosan. Especially, TPPACSC exhibited the best antifungal property with inhibitory indices of over 75% at 1.0 mg/mL. The results obviously showed that quaternary phosphonium groups could effectively enhance antifungal activity of the synthesized chitosan derivatives. Meanwhile, it was also found that their antifungal activity was influenced by electron-withdrawing ability of the quaternary phosphonium salts. The synthetic strategy described here could be utilized for the development of chitosan as antifungal biomaterials. (C) 2017 Elsevier B.V. All rights reserved.
关键词Chitosan Derivatives Quaternary Phosphonium Salts Functional Antifungal Activity Electron-withdrawing Ability
DOI10.1016/j.ijbiomac.2017.04.073
项目资助者National Natural Science Foundation of China(41576156) ; Shandong Province Science and Technology Development Plan(2015GSF121045) ; Yantai Science and Technology Development Plan(2015ZH078) ; Public Science and Technology Research Funds Projects of Ocean(201505022-3)
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收录类别SCI
关键词[WOS]ANTIBACTERIAL ACTIVITY ; ANTIMICROBIAL ACTIVITY ; CARBOXYMETHYL CHITOSAN ; AMMONIUM CHITOSAN ; ANTIOXIDANT ; COPOLYMERS ; HYDROGEL ; IONS
文章类型Article
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS记录号WOS:000406984300077
引用统计
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/23415
专题海岸带生物学与生物资源利用所重点实验室
通讯作者Guo, Zhanyong; Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China)
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China
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GB/T 7714
Tan, Wenqiang,Zhang, Jingjing,Luan, Fang,et al. Design, synthesis of novel chitosan derivatives bearing quaternary phosphonium salts and evaluation of antifungal activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,102:704-711.
APA Tan, Wenqiang.,Zhang, Jingjing.,Luan, Fang.,Wei, Lijie.,Chen, Yuan.,...&Guo, Zhanyong.(2017).Design, synthesis of novel chitosan derivatives bearing quaternary phosphonium salts and evaluation of antifungal activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,102,704-711.
MLA Tan, Wenqiang,et al."Design, synthesis of novel chitosan derivatives bearing quaternary phosphonium salts and evaluation of antifungal activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 102(2017):704-711.
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