Design, synthesis of novel chitosan derivatives bearing quaternary phosphonium salts and evaluation of antifungal activity

doi:10.1016/j.ijbiomac.2017.04.073

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	Design, synthesis of novel chitosan derivatives bearing quaternary phosphonium salts and evaluation of antifungal activity
	Tan, Wenqiang1,2 ; Zhang, Jingjing 1,2; Luan, Fang 1,2; Wei, Lijie 1,2; Chen, Yuan 3; Dong, Fang1 ; Li, Qing 1; Guo, Zhanyong1,2 ; Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China)
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
	2017-09-01
卷号	102 页码:704-711
关键词	Chitosan Derivatives Quaternary Phosphonium Salts Functional Antifungal Activity Electron-withdrawing Ability
研究领域	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
DOI	10.1016/j.ijbiomac.2017.04.073
产权排序	第1完成单位
作者部门	海岸带生物资源高效利用研究与发展中心
英文摘要	Two novel chitosan derivatives modified with quaternary phosphonium salts were successfully synthesized, including tricyclohexylphosphonium acetyl chitosan chloride (TCPACSC) and triphenylphosphonium acetyl chitosan chloride (TPPACSC), and characterized by FTIR, H-1 NMR, and C-13 NMR spectra. The degree of substitution was also calculated by elemental analysis results. Their antifungal activities against Colletotrichum lagenarium, Watermelon fusarium, and Fusarium oxysporum were investigated in vitro using the radial growth assay, minimal inhibitory concentration, and minimum bactericidal concentration assay. The fungicidal assessment revealed that the synthesized chitosan derivatives had superior antifungal activity compared with chitosan. Especially, TPPACSC exhibited the best antifungal property with inhibitory indices of over 75% at 1.0 mg/mL. The results obviously showed that quaternary phosphonium groups could effectively enhance antifungal activity of the synthesized chitosan derivatives. Meanwhile, it was also found that their antifungal activity was influenced by electron-withdrawing ability of the quaternary phosphonium salts. The synthetic strategy described here could be utilized for the development of chitosan as antifungal biomaterials. (C) 2017 Elsevier B.V. All rights reserved.
文章类型	Article
资助机构	National Natural Science Foundation of China(41576156) ; Shandong Province Science and Technology Development Plan(2015GSF121045) ; Yantai Science and Technology Development Plan(2015ZH078) ; Public Science and Technology Research Funds Projects of Ocean(201505022-3)
收录类别	SCI
语种	英语
关键词[WOS]	ANTIBACTERIAL ACTIVITY ; ANTIMICROBIAL ACTIVITY ; CARBOXYMETHYL CHITOSAN ; AMMONIUM CHITOSAN ; ANTIOXIDANT ; COPOLYMERS ; HYDROGEL ; IONS
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS记录号	WOS:000406984300077
引用统计	被引频次：50[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/23415
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
通讯作者	Guo, Zhanyong; Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China)
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Tan, Wenqiang,Zhang, Jingjing,Luan, Fang,et al. Design, synthesis of novel chitosan derivatives bearing quaternary phosphonium salts and evaluation of antifungal activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,102:704-711.
APA	Tan, Wenqiang.,Zhang, Jingjing.,Luan, Fang.,Wei, Lijie.,Chen, Yuan.,...&Guo, Zhanyong.(2017).Design, synthesis of novel chitosan derivatives bearing quaternary phosphonium salts and evaluation of antifungal activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,102,704-711.
MLA	Tan, Wenqiang,et al."Design, synthesis of novel chitosan derivatives bearing quaternary phosphonium salts and evaluation of antifungal activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 102(2017):704-711.