Inulin with different degrees of polymerization modulates composition of intestinal microbiota in mice
Zhu, Limeng1,2; Qin, Song1; Zhai, Shixiang1; Gao, Yonglin3; Li, Lili1
2017-05-01
发表期刊FEMS MICROBIOLOGY LETTERS
ISSN0378-1097
卷号364期号:10
摘要The study aimed to analyze the global influences of dietary inulin with different degrees of polymerization (DP) on intestinal microbial communities. Six-week-old male C57BL/6J mice were treated with fructo-oligosaccharides and inulin for 6 weeks. Fecal samples were obtained at time point 0 and 6th week. 16S rRNA sequence analysis was used to measure intestinal microbiota performed on the Illumina MiSeq platform. Influences of dietary inulin on intestinal microbiota were more complex effects than bifidogenic effects, relative abundance of butyrate-producing bacteria increased after interventions. Akkermansia muciniphila, belonging to mucin-degrading species, became a dominant species in Verrucomicrobia phylum after treatment with fructo-oligosaccharides and inulin. Modulation effects of intestinal microbiota were positively correlated with DP. Lower DP interventions exhibited better effects than higher DP treatment on stimulation of probiotics. We hypothesized that Akkermansia muciniphila played an important role on maintaining balance between mucin and short chain fatty acids.
关键词Butyrate-producing Bacteria Degrees Of Polymerization Fructo-oligosaccharides Intestinal Microbiota Inulin Metagenomics
DOI10.1093/femsle/fnx075
项目资助者National Natural Science Foundation of China(21306221) ; National Key Technology Research and Development Program of China(2013BAB01B01) ; Science and Technology Development Program of Shandong Province(2010GSF10208)
收录类别SCI
关键词[WOS]CHAIN FATTY-ACID ; BUTYRATE-PRODUCING BACTERIA ; GUT MICROBIOTA ; AKKERMANSIA-MUCINIPHILA ; HEALTH ; STIMULATION ; DIVERSITY ; DIETARY ; COLON ; RATS
文章类型Article
语种英语
WOS研究方向Microbiology
WOS记录号WOS:000404534500010
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/22546
专题海岸带生物学与生物资源利用所重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Costal Zone Res, 17 Chunhui Rd, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Yantai Univ, Yantai 264003, Peoples R China
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GB/T 7714
Zhu, Limeng,Qin, Song,Zhai, Shixiang,et al. Inulin with different degrees of polymerization modulates composition of intestinal microbiota in mice[J]. FEMS MICROBIOLOGY LETTERS,2017,364(10).
APA Zhu, Limeng,Qin, Song,Zhai, Shixiang,Gao, Yonglin,&Li, Lili.(2017).Inulin with different degrees of polymerization modulates composition of intestinal microbiota in mice.FEMS MICROBIOLOGY LETTERS,364(10).
MLA Zhu, Limeng,et al."Inulin with different degrees of polymerization modulates composition of intestinal microbiota in mice".FEMS MICROBIOLOGY LETTERS 364.10(2017).
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