Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve; Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve
Li, Bowei1; Yu, Lijuan2; Qi, Ji3; Fu, Longwen1; Zhang, Peiqing2; Chen, Lingxin1,2
发表期刊ANALYTICAL CHEMISTRY ; ANALYTICAL CHEMISTRY
ISSN0003-2700 ; 0003-2700
2017-06-06 ; 2017-06-06
卷号89期号:11页码:5708-5713
关键词ELECTROCHEMILUMINESCENCE IMMUNODEVICE ELECTROCHEMILUMINESCENCE IMMUNODEVICE CHEMILUMINESCENCE IMMUNOASSAY CHEMILUMINESCENCE IMMUNOASSAY LAYERED PAPER LAYERED PAPER LOW-COST LOW-COST FLOW FLOW HYDROGEL HYDROGEL ARRAYS ARRAYS
研究领域Chemistry, Analytical ; Chemistry, Analytical
DOI10.1021/acs.analchem.7b00726 ; 10.1021/acs.analchem.7b00726
产权排序[Li, Bowei; [Li, Bowei; Fu, Longwen; Fu, Longwen; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Yu, Lijuan; [Yu, Lijuan; Zhang, Peiqing; Zhang, Peiqing; Chen, Lingxin] Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China; Chen, Lingxin] Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China; [Qi, Ji] Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China; [Qi, Ji] Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China
作者部门海岸带环境工程技术研究与发展中心 ; 海岸带环境工程技术研究与发展中心
英文摘要This paper describes a novel, strategy for fabricating the movable valve on paper-based microfluidic devices to manipulate capillary-driven fluids. The movable valve fabrication is first realized using hollow rivets as the-holding center it, control the paper channel in different layer movement that Jesuits in the :channel's connection or disconnection. The relatively simple Valve fabrication procedure is robust, Versatile, and, compatible with microfluidic paper-based analytical devices (mu PADs) with differing levels of complexity. It is remarkable that the movable valve can be convenient and free to control fluid without the timing setting; advantages that make it user-friendly for untrained users to carry out the complex multistep operations. For the, performance of the Movable valve to be-verified, several different designs of mu PADs were tested and obtained with satisfactory results. In addition; in the proof-of-concept enzyme-linked immunosorbent assay experiments, we demonstrate the use of these valves in mu PADs for the successful analysis of samples of carcino-embryonic antigen, showing good sensitivity and reproducibility. We hope this technique will open new avenues for the fabrication of paper-based valves in an easily adoptable and widely available way on mu PADs and provide potential point-of-Care applications in the future.; This paper describes a novel, strategy for fabricating the movable valve on paper-based microfluidic devices to manipulate capillary-driven fluids. The movable valve fabrication is first realized using hollow rivets as the-holding center it, control the paper channel in different layer movement that Jesuits in the :channel's connection or disconnection. The relatively simple Valve fabrication procedure is robust, Versatile, and, compatible with microfluidic paper-based analytical devices (mu PADs) with differing levels of complexity. It is remarkable that the movable valve can be convenient and free to control fluid without the timing setting; advantages that make it user-friendly for untrained users to carry out the complex multistep operations. For the, performance of the Movable valve to be-verified, several different designs of mu PADs were tested and obtained with satisfactory results. In addition; in the proof-of-concept enzyme-linked immunosorbent assay experiments, we demonstrate the use of these valves in mu PADs for the successful analysis of samples of carcino-embryonic antigen, showing good sensitivity and reproducibility. We hope this technique will open new avenues for the fabrication of paper-based valves in an easily adoptable and widely available way on mu PADs and provide potential point-of-Care applications in the future.
文章类型Article ; Article
资助机构Natural Science Research Foundation of China(21575159 ; Natural Science Research Foundation of China(21575159 ; Science and Technology Development Plan of Yantai(2015ZH087) ; Science and Technology Development Plan of Yantai(2015ZH087) ; National Key Research and Development Program of China(2016YFC1400702) ; National Key Research and Development Program of China(2016YFC1400702) ; 21205131) ; 21205131)
收录类别SCI ; SCI
语种英语 ; 英语
关键词[WOS]CHEMILUMINESCENCE IMMUNOASSAY ; CHEMILUMINESCENCE IMMUNOASSAY ; LAYERED PAPER ; LAYERED PAPER ; LOW-COST ; LOW-COST ; FLOW ; FLOW ; IMMUNODEVICE ; IMMUNODEVICE ; ARRAYS ; ARRAYS
研究领域[WOS]Chemistry ; Chemistry
WOS记录号WOS:000403036800012 ; WOS:000403036800012
引用统计
被引频次:75[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/22530
专题中国科学院海岸带环境过程与生态修复重点实验室
中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China
3.Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China
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Li, Bowei,Yu, Lijuan,Qi, Ji,et al. Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve, Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve[J]. ANALYTICAL CHEMISTRY, ANALYTICAL CHEMISTRY,2017, 2017,89, 89(11):5708-5713, 5708-5713.
APA Li, Bowei,Yu, Lijuan,Qi, Ji,Fu, Longwen,Zhang, Peiqing,&Chen, Lingxin.(2017).Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve.ANALYTICAL CHEMISTRY,89(11),5708-5713.
MLA Li, Bowei,et al."Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve".ANALYTICAL CHEMISTRY 89.11(2017):5708-5713.
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