Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve; Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve | |
Li, Bowei1; Yu, Lijuan2; Qi, Ji3; Fu, Longwen1; Zhang, Peiqing2; Chen, Lingxin1,2 | |
发表期刊 | ANALYTICAL CHEMISTRY ; ANALYTICAL CHEMISTRY |
ISSN | 0003-2700 ; 0003-2700 |
2017-06-06 ; 2017-06-06 | |
卷号 | 89期号:11页码:5708-5713 |
关键词 | ELECTROCHEMILUMINESCENCE IMMUNODEVICE ELECTROCHEMILUMINESCENCE IMMUNODEVICE CHEMILUMINESCENCE IMMUNOASSAY CHEMILUMINESCENCE IMMUNOASSAY LAYERED PAPER LAYERED PAPER LOW-COST LOW-COST FLOW FLOW HYDROGEL HYDROGEL ARRAYS ARRAYS |
研究领域 | Chemistry, Analytical ; Chemistry, Analytical |
DOI | 10.1021/acs.analchem.7b00726 ; 10.1021/acs.analchem.7b00726 |
产权排序 | [Li, Bowei; [Li, Bowei; Fu, Longwen; Fu, Longwen; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Yu, Lijuan; [Yu, Lijuan; Zhang, Peiqing; Zhang, Peiqing; Chen, Lingxin] Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China; Chen, Lingxin] Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China; [Qi, Ji] Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China; [Qi, Ji] Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China |
作者部门 | 海岸带环境工程技术研究与发展中心 ; 海岸带环境工程技术研究与发展中心 |
英文摘要 | This paper describes a novel, strategy for fabricating the movable valve on paper-based microfluidic devices to manipulate capillary-driven fluids. The movable valve fabrication is first realized using hollow rivets as the-holding center it, control the paper channel in different layer movement that Jesuits in the :channel's connection or disconnection. The relatively simple Valve fabrication procedure is robust, Versatile, and, compatible with microfluidic paper-based analytical devices (mu PADs) with differing levels of complexity. It is remarkable that the movable valve can be convenient and free to control fluid without the timing setting; advantages that make it user-friendly for untrained users to carry out the complex multistep operations. For the, performance of the Movable valve to be-verified, several different designs of mu PADs were tested and obtained with satisfactory results. In addition; in the proof-of-concept enzyme-linked immunosorbent assay experiments, we demonstrate the use of these valves in mu PADs for the successful analysis of samples of carcino-embryonic antigen, showing good sensitivity and reproducibility. We hope this technique will open new avenues for the fabrication of paper-based valves in an easily adoptable and widely available way on mu PADs and provide potential point-of-Care applications in the future.; This paper describes a novel, strategy for fabricating the movable valve on paper-based microfluidic devices to manipulate capillary-driven fluids. The movable valve fabrication is first realized using hollow rivets as the-holding center it, control the paper channel in different layer movement that Jesuits in the :channel's connection or disconnection. The relatively simple Valve fabrication procedure is robust, Versatile, and, compatible with microfluidic paper-based analytical devices (mu PADs) with differing levels of complexity. It is remarkable that the movable valve can be convenient and free to control fluid without the timing setting; advantages that make it user-friendly for untrained users to carry out the complex multistep operations. For the, performance of the Movable valve to be-verified, several different designs of mu PADs were tested and obtained with satisfactory results. In addition; in the proof-of-concept enzyme-linked immunosorbent assay experiments, we demonstrate the use of these valves in mu PADs for the successful analysis of samples of carcino-embryonic antigen, showing good sensitivity and reproducibility. We hope this technique will open new avenues for the fabrication of paper-based valves in an easily adoptable and widely available way on mu PADs and provide potential point-of-Care applications in the future. |
文章类型 | Article ; Article |
资助机构 | Natural Science Research Foundation of China(21575159 ; Natural Science Research Foundation of China(21575159 ; Science and Technology Development Plan of Yantai(2015ZH087) ; Science and Technology Development Plan of Yantai(2015ZH087) ; National Key Research and Development Program of China(2016YFC1400702) ; National Key Research and Development Program of China(2016YFC1400702) ; 21205131) ; 21205131) |
收录类别 | SCI ; SCI |
语种 | 英语 ; 英语 |
关键词[WOS] | CHEMILUMINESCENCE IMMUNOASSAY ; CHEMILUMINESCENCE IMMUNOASSAY ; LAYERED PAPER ; LAYERED PAPER ; LOW-COST ; LOW-COST ; FLOW ; FLOW ; IMMUNODEVICE ; IMMUNODEVICE ; ARRAYS ; ARRAYS |
研究领域[WOS] | Chemistry ; Chemistry |
WOS记录号 | WOS:000403036800012 ; WOS:000403036800012 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/22530 |
专题 | 中国科学院海岸带环境过程与生态修复重点实验室 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心 |
作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China 3.Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Bowei,Yu, Lijuan,Qi, Ji,et al. Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve, Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve[J]. ANALYTICAL CHEMISTRY, ANALYTICAL CHEMISTRY,2017, 2017,89, 89(11):5708-5713, 5708-5713. |
APA | Li, Bowei,Yu, Lijuan,Qi, Ji,Fu, Longwen,Zhang, Peiqing,&Chen, Lingxin.(2017).Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve.ANALYTICAL CHEMISTRY,89(11),5708-5713. |
MLA | Li, Bowei,et al."Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve".ANALYTICAL CHEMISTRY 89.11(2017):5708-5713. |
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