Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve
Li, Bowei1; Yu, Lijuan2; Qi, Ji3; Fu, Longwen1; Zhang, Peiqing2; Chen, Lingxin1,2
2017-06-06
发表期刊ANALYTICAL CHEMISTRY
ISSN0003-2700
卷号89期号:11页码:5708-5713
摘要This paper describes a novel, strategy for fabricating the movable valve on paper-based microfluidic devices to manipulate capillary-driven fluids. The movable valve fabrication is first realized using hollow rivets as the-holding center it, control the paper channel in different layer movement that Jesuits in the :channel's connection or disconnection. The relatively simple Valve fabrication procedure is robust, Versatile, and, compatible with microfluidic paper-based analytical devices (mu PADs) with differing levels of complexity. It is remarkable that the movable valve can be convenient and free to control fluid without the timing setting; advantages that make it user-friendly for untrained users to carry out the complex multistep operations. For the, performance of the Movable valve to be-verified, several different designs of mu PADs were tested and obtained with satisfactory results. In addition; in the proof-of-concept enzyme-linked immunosorbent assay experiments, we demonstrate the use of these valves in mu PADs for the successful analysis of samples of carcino-embryonic antigen, showing good sensitivity and reproducibility. We hope this technique will open new avenues for the fabrication of paper-based valves in an easily adoptable and widely available way on mu PADs and provide potential point-of-Care applications in the future.
DOI10.1021/acs.analchem.7b00726
项目资助者Natural Science Research Foundation of China(21575159 ; Science and Technology Development Plan of Yantai(2015ZH087) ; National Key Research and Development Program of China(2016YFC1400702) ; 21205131)
收录类别SCI
关键词[WOS]CHEMILUMINESCENCE IMMUNOASSAY ; LAYERED PAPER ; LOW-COST ; FLOW ; IMMUNODEVICE ; ARRAYS
文章类型Article
语种英语
WOS研究方向Chemistry
WOS记录号WOS:000403036800012
引用统计
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/22530
专题中科院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China
3.Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China
第一作者单位中国科学院烟台海岸带研究所
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Li, Bowei,Yu, Lijuan,Qi, Ji,et al. Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve[J]. ANALYTICAL CHEMISTRY,2017,89(11):5708-5713.
APA Li, Bowei,Yu, Lijuan,Qi, Ji,Fu, Longwen,Zhang, Peiqing,&Chen, Lingxin.(2017).Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve.ANALYTICAL CHEMISTRY,89(11),5708-5713.
MLA Li, Bowei,et al."Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve".ANALYTICAL CHEMISTRY 89.11(2017):5708-5713.
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