Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-kappa B signaling pathway
Li, Chengcheng1; Yu, Yan1; Li, Wenjun2; Liu, Bo1; Jiao, Xudong2; Song, Xinyu1; Lv, Changjun3; Qin, Song2
2017-07-19
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号7
摘要Our aim was to investigate the effects of phycocyanin (PC) on bleomycin (BLM)-induced pulmonary fibrosis (PF). In this study, C57 BL/6 wild-type (WT) mice and toll-like receptor (TLR) 2 deficient mice were treated with PC for 28 days following BLM exposure. Serum and lung tissues were collected on days 3, 7 and 28. Data shows PC significantly decreased the levels of hydroxyproline (HYP), vimentin, surfactant-associated protein C (SP-C), fibroblast specific protein-1 (S100A4) and a-smooth muscle actin (a-SMA) but dramatically increased E-cadherin and podoplanin (PDPN) expression on day 28. Moreover, PC greatly decreased the levels of interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a) and myeloperoxidase (MPO) at the earlier time. Reduced expression of key genes in the TLR2 pathway was also detected. Compared with WT mice, TLR2-deficient mice exhibited less injury, and the protective effect of PC was partly diminished in this background. These data indicate the anti-fibrotic effects of PC may be mediated by reducing W/D ratio, MPO, IL-6, TNF-alpha, protecting type I alveolar epithelial cells, inhibiting fibroblast proliferation, attenuating epithelial-mesenchymal transitions (EMT) and reducing oxidative stress. The TLR2-MyD88-NF-kappa B pathway plays an important role in PC-mediated reduction in pulmonary fibrosis.
DOI10.1038/s41598-017-06021-5
项目资助者National Natural Science Foundation of China(31470415 ; Taishan Scholar Project ; 81670064 ; 41176144 ; 41376139)
收录类别SCI
关键词[WOS]ACUTE LUNG INJURY ; C-PHYCOCYANIN ; EPITHELIAL-CELLS ; MESENCHYMAL TRANSITION ; GENE-EXPRESSION ; KAPPA-B ; MICE ; INFLAMMATION ; RATS ; SPIRULINA
文章类型Article
语种英语
WOS研究方向Science & Technology - Other Topics
WOS记录号WOS:000405894200061
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/22520
专题海岸带生物学与生物资源利用所重点实验室
作者单位1.Binzhou Med Univ, Med & Pharm Res Ctr, Yantai, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China
3.Binzhou Med Univ, Dept Resp Med, Affiliated Hosp, Binzhou, Peoples R China
推荐引用方式
GB/T 7714
Li, Chengcheng,Yu, Yan,Li, Wenjun,et al. Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-kappa B signaling pathway[J]. SCIENTIFIC REPORTS,2017,7.
APA Li, Chengcheng.,Yu, Yan.,Li, Wenjun.,Liu, Bo.,Jiao, Xudong.,...&Qin, Song.(2017).Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-kappa B signaling pathway.SCIENTIFIC REPORTS,7.
MLA Li, Chengcheng,et al."Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-kappa B signaling pathway".SCIENTIFIC REPORTS 7(2017).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Chengcheng]的文章
[Yu, Yan]的文章
[Li, Wenjun]的文章
百度学术
百度学术中相似的文章
[Li, Chengcheng]的文章
[Yu, Yan]的文章
[Li, Wenjun]的文章
必应学术
必应学术中相似的文章
[Li, Chengcheng]的文章
[Yu, Yan]的文章
[Li, Wenjun]的文章
相关权益政策
暂无数据
收藏/分享
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。