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Effects of pyrene exposure on immune response and oxidative stress in the pearl oyster, Pinctada martensii
Xie, Jia1,2,3; Zhao, Chunfeng1,2; Han, Qian1,2; Zhou, Hailong1,2; Li, Qingxiao4; Diao, Xiaoping1,2; Zhou, HL
2017-04-01
发表期刊FISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
卷号63页码:237-244
产权排序[Xie, Jia; Zhao, Chunfeng; Han, Qian; Zhou, Hailong; Diao, Xiaoping] Hainan Univ, State Key Lab South China Sea Marine Resource Uti, Haikou 570228, Peoples R China; [Xie, Jia; Zhao, Chunfeng; Han, Qian; Zhou, Hailong; Diao, Xiaoping] Hainan Univ, Inst Trop Agr & Forestry, 58 Renmin Rd, Haikou 570228, Hainan, Peoples R China; [Xie, Jia] Chinese Acad Sci, Yantai Inst Coastal Zone Res, 17,Chunhui Rd, Laishan Dist 264003, Yantai, Peoples R China; [Li, Qingxiao] Univ Hawaii Manoa, Dept Mol Biosci & Bioengn, 1955 East West Rd, Honolulu, HI 96822 USA
摘要Pyrene is a polycyclic aromatic hydrocarbon (PAH) commonly observed in. aquatic ecosystems, which originates primarily from the incomplete combustion of fossil fuels and the use of petroleum compounds. Pyrene can cause the immune disturbance and oxidative stress, result in immunotoxicity, DNA damage, reduce reproduction significantly, and induce behavioral changes. Marine bivalves are commonly used as bioindicators for marine pollution, and hemolymph is a metabolite transfer medium for PAH pollutant. However, the vital immune indicator responses of pearl oyster Pinctada martensii hemolymph exposed to pyrene is still unclear. Thus, the immunotoxic responses of pyrene on the hemolymph of the Pinctada martensii were investigated in this study. After exposure to pyrene for 7 days, the total number of hemocytes (THC), cell membrane stability (CMS), phagocytic activity (PA) and total glutathione (GSHT) all decreased significantly. Pyrene also caused a significant increase in lipid peroxidation (LPO). Median effective concentrations (EC50) of pyrene on THC (4.5 mu g L-1) and LPO (5.2 mu g L-1) were lower than those for CMS (13.8 mu g L-1), PA (12.1 mu g L-1) and GSHT (7.2 mu g L-1), which indicates that THC and LPO were more sensitive. Additionally, a clear dose-effect relationship indicated that pyrene stimulated a marked immune response, as well as oxidative stress in P. martensii, which demonstrates the subtle effects of pyrene exposure on marine invertebrates and the potential associated risk. (C) 2017 Elsevier Ltd. All rights reserved.
关键词Pinctada Martensii Hemocyte Pyrene Immunotoxicity Oxidative Stress
作者部门中科院烟台海岸带研究所知识产出
学科领域Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
DOI10.1016/j.fsi.2017.02.032
项目资助者National Natural Science Foundation of China(31160126) ; Specialized Research Fund for the Midwest Programme of Hainan University(ZXBJH-XK002) ; Specialized Research Fund for the Doctoral Programme of Higher Education of China(20114601120001)
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收录类别SCI
关键词[WOS]POLYCYCLIC AROMATIC-HYDROCARBONS ; MUSSEL MYTILUS-EDULIS ; ECOLOGICAL RISK-ASSESSMENT ; MARINE MUSSEL ; OIL-SPILL ; HALIOTIS-DIVERSICOLOR ; CRASSOSTREA-GIGAS ; BIVALVE IMMUNITY ; PACIFIC OYSTER ; YANGPU BAY
文章类型Article
语种英语
WOS研究方向Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS记录号WOS:000398870700026
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文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/22096
专题中科院烟台海岸带研究所知识产出
通讯作者Zhou, HL
作者单位1.Hainan Univ, State Key Lab South China Sea Marine Resource Uti, Haikou 570228, Peoples R China
2.Hainan Univ, Inst Trop Agr & Forestry, 58 Renmin Rd, Haikou 570228, Hainan, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, 17,Chunhui Rd, Laishan Dist 264003, Yantai, Peoples R China
4.Univ Hawaii Manoa, Dept Mol Biosci & Bioengn, 1955 East West Rd, Honolulu, HI 96822 USA
第一作者单位中国科学院烟台海岸带研究所
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Xie, Jia,Zhao, Chunfeng,Han, Qian,et al. Effects of pyrene exposure on immune response and oxidative stress in the pearl oyster, Pinctada martensii[J]. FISH & SHELLFISH IMMUNOLOGY,2017,63:237-244.
APA Xie, Jia.,Zhao, Chunfeng.,Han, Qian.,Zhou, Hailong.,Li, Qingxiao.,...&Zhou, HL.(2017).Effects of pyrene exposure on immune response and oxidative stress in the pearl oyster, Pinctada martensii.FISH & SHELLFISH IMMUNOLOGY,63,237-244.
MLA Xie, Jia,et al."Effects of pyrene exposure on immune response and oxidative stress in the pearl oyster, Pinctada martensii".FISH & SHELLFISH IMMUNOLOGY 63(2017):237-244.
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