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Quantum Dot-Based Molecularly Imprinted Polymers on Three-Dimensional Origami Paper Microfluidic Chip for Fluorescence Detection of Phycocyanin
Li, Bowei1; Zhang, Zhong1,2; Qi, Ji1,4; Zhou, Na1; Qin, Song1; Choo, Jaebum3; Chen, Lingxin1,4; Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China.; Choo, J (reprint author), Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea.; Chen, LX (reprint author), Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China. jbchoo@hanyang.ac.kr; lxchen@yic.ac.cn
2017-02-01
Source PublicationACS SENSORS
ISSN2379-3694
Volume2Issue:2Pages:243-250
Contribution Rank[Li, Bowei; Zhang, Zhong; Qi, Ji; Zhou, Na; Qin, Song; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Zhang, Zhong] Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian 710119, Peoples R China; [Choo, Jaebum] Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea; [Qi, Ji; Chen, Lingxin] Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China
AbstractIn this work, we developed a novel strategy using fluorescent quantum dots (QDs) combined with molecularly imprinted polymers (MIPs) on three-dimensional (3D) origami paper-based microfluidic devices for specific recognition and sensitive detection of phycocyanin. This method can realize the liquid phase of QDs@MIPs being transferred to the solid-phase paper base and achieve easy portability for the analysis. Under optimal conditions, we successfully demonstrated the proposed paper@QDs@MIP5 3D microfluidic chip for the sensitive and selective detection of phycocyanin protein target in a simple and robust manner. Our results revealed that the method exhibited a dynamic response to phycocyanin in the range of 10-50 mg/L with a limit of detection of 2 mg/L. Importantly, this device could provide quantitative information very conveniently and show great potential to be further extended to the detection of other proteins or biomarkers for environmental and food safety research.
KeywordPaper-based Microfluidic Devices Molecularly Imprinted Polymers (Mips) Quantum Dot Phycocyanin Fluorescence
Department中科院海岸带环境过程与生态修复重点实验室
Subject AreaChemistry ; Science & Technology - Other Topics
DOI10.1021/acssensors.6b00664
Funding OrganizationNational Defense Science and Technology Innovation Project of Chinese Academy of Sciences(CXJJ-16M254) ; Science and Technology Development Plan of Yantai(2015ZH087) ; Natural Science Research Foundation of China(21205131 ; Fundamental Research Funds for the Central Universities in China(GK201603099) ; Shanxi Province Agricultural Science and Technology Innovation ; Key Project(2016NY-181) ; Korea Health Industry Development Institute (KHIDI) - Ministry of Health and Welfare, Korea(H116C2129) ; 41406125)
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Indexed BySCI
WOS KeywordMETHYLAMINO-L-ALANINE ; NEUROTOXIC AMINO-ACID ; CYANOBACTERIAL TOXINS ; SIGNAL AMPLIFICATION ; DEVICE ; MICROSPHERES ; COOCCURRENCE ; RECOGNITION ; POPULATIONS ; BIOASSAYS
SubtypeArticle
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics
WOS IDWOS:000395047000009
Citation statistics
Cited Times:40[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/22072
Collection中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorChen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China.; Choo, J (reprint author), Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea.; Chen, LX (reprint author), Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China. jbchoo@hanyang.ac.kr; lxchen@yic.ac.cn
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian 710119, Peoples R China
3.Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea
4.Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China
First Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Bowei,Zhang, Zhong,Qi, Ji,et al. Quantum Dot-Based Molecularly Imprinted Polymers on Three-Dimensional Origami Paper Microfluidic Chip for Fluorescence Detection of Phycocyanin[J]. ACS SENSORS,2017,2(2):243-250.
APA Li, Bowei.,Zhang, Zhong.,Qi, Ji.,Zhou, Na.,Qin, Song.,...&lxchen@yic.ac.cn.(2017).Quantum Dot-Based Molecularly Imprinted Polymers on Three-Dimensional Origami Paper Microfluidic Chip for Fluorescence Detection of Phycocyanin.ACS SENSORS,2(2),243-250.
MLA Li, Bowei,et al."Quantum Dot-Based Molecularly Imprinted Polymers on Three-Dimensional Origami Paper Microfluidic Chip for Fluorescence Detection of Phycocyanin".ACS SENSORS 2.2(2017):243-250.
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