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题名:
Quantum Dot-Based Molecularly Imprinted Polymers on Three-Dimensional Origami Paper Microfluidic Chip for Fluorescence Detection of Phycocyanin
作者: Li BoWei(李博伟)1; Zhang, Zhong1,2; Qi, Ji1,4; Zhou, Na1; Qin, Song1; Choo, Jaebum3; Chen, Lingxin1,4
刊名: ACS SENSORS
ISSN号: 2379-3694
出版日期: 2017-02-01
卷号: 2, 期号:2, 页码:243-250
关键词: paper-based microfluidic devices ; molecularly imprinted polymers (MIPs) ; quantum dot ; phycocyanin ; fluorescence
学科分类: Chemistry; Science & Technology - Other Topics
DOI: 10.1021/acssensors.6b00664
产权排序: [Li, Bowei; Zhang, Zhong; Qi, Ji; Zhou, Na; Qin, Song; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Zhang, Zhong] Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian 710119, Peoples R China; [Choo, Jaebum] Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea; [Qi, Ji; Chen, Lingxin] Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China
通讯作者: Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. ; Choo, J (reprint author), Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea. ; Chen, LX (reprint author), Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China. jbchoo@hanyang.ac.kr ; lxchen@yic.ac.cn
作者部门: 中科院海岸带环境过程与生态修复重点实验室
英文摘要: In this work, we developed a novel strategy using fluorescent quantum dots (QDs) combined with molecularly imprinted polymers (MIPs) on three-dimensional (3D) origami paper-based microfluidic devices for specific recognition and sensitive detection of phycocyanin. This method can realize the liquid phase of QDs@MIPs being transferred to the solid-phase paper base and achieve easy portability for the analysis. Under optimal conditions, we successfully demonstrated the proposed paper@QDs@MIP5 3D microfluidic chip for the sensitive and selective detection of phycocyanin protein target in a simple and robust manner. Our results revealed that the method exhibited a dynamic response to phycocyanin in the range of 10-50 mg/L with a limit of detection of 2 mg/L. Importantly, this device could provide quantitative information very conveniently and show great potential to be further extended to the detection of other proteins or biomarkers for environmental and food safety research.
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics
项目资助者: National Defense Science and Technology Innovation Project of Chinese Academy of Sciences(CXJJ-16M254) ; Science and Technology Development Plan of Yantai(2015ZH087) ; Natural Science Research Foundation of China(21205131 ; Fundamental Research Funds for the Central Universities in China(GK201603099) ; Shanxi Province Agricultural Science and Technology Innovation ; Key Project(2016NY-181) ; Korea Health Industry Development Institute (KHIDI) - Ministry of Health and Welfare, Korea(H116C2129) ; 41406125)
关键词[WOS]: METHYLAMINO-L-ALANINE ; NEUROTOXIC AMINO-ACID ; CYANOBACTERIAL TOXINS ; SIGNAL AMPLIFICATION ; DEVICE ; MICROSPHERES ; COOCCURRENCE ; RECOGNITION ; POPULATIONS ; BIOASSAYS
文章类型: Article
收录类别: SCI
原文出处: 查看原文
语种: 英语
WOS记录号: WOS:000395047000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.yic.ac.cn/handle/133337/22072
Appears in Collections:中科院海岸带环境过程与生态修复重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian 710119, Peoples R China
3.Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea
4.Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China

Recommended Citation:
Li, Bowei,Zhang, Zhong,Qi, Ji,et al. Quantum Dot-Based Molecularly Imprinted Polymers on Three-Dimensional Origami Paper Microfluidic Chip for Fluorescence Detection of Phycocyanin[J]. ACS SENSORS,2017,2(2):243-250.
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