Quantum Dot-Based Molecularly Imprinted Polymers on Three-Dimensional Origami Paper Microfluidic Chip for Fluorescence Detection of Phycocyanin
Li, Bowei1; Zhang, Zhong1,2; Qi, Ji1,4; Zhou, Na1; Qin, Song1; Choo, Jaebum3; Chen, Lingxin1,4; Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China.; Choo, J (reprint author), Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea.; Chen, LX (reprint author), Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China. jbchoo@hanyang.ac.kr; lxchen@yic.ac.cn
2017-02-01
发表期刊ACS SENSORS
ISSN2379-3694
卷号2期号:2页码:243-250
产权排序[Li, Bowei; Zhang, Zhong; Qi, Ji; Zhou, Na; Qin, Song; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Zhang, Zhong] Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian 710119, Peoples R China; [Choo, Jaebum] Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea; [Qi, Ji; Chen, Lingxin] Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China
摘要In this work, we developed a novel strategy using fluorescent quantum dots (QDs) combined with molecularly imprinted polymers (MIPs) on three-dimensional (3D) origami paper-based microfluidic devices for specific recognition and sensitive detection of phycocyanin. This method can realize the liquid phase of QDs@MIPs being transferred to the solid-phase paper base and achieve easy portability for the analysis. Under optimal conditions, we successfully demonstrated the proposed paper@QDs@MIP5 3D microfluidic chip for the sensitive and selective detection of phycocyanin protein target in a simple and robust manner. Our results revealed that the method exhibited a dynamic response to phycocyanin in the range of 10-50 mg/L with a limit of detection of 2 mg/L. Importantly, this device could provide quantitative information very conveniently and show great potential to be further extended to the detection of other proteins or biomarkers for environmental and food safety research.
关键词Paper-based Microfluidic Devices Molecularly Imprinted Polymers (Mips) Quantum Dot Phycocyanin Fluorescence
作者部门中科院海岸带环境过程与生态修复重点实验室
学科领域Chemistry ; Science & Technology - Other Topics
DOI10.1021/acssensors.6b00664
项目资助者National Defense Science and Technology Innovation Project of Chinese Academy of Sciences(CXJJ-16M254) ; Science and Technology Development Plan of Yantai(2015ZH087) ; Natural Science Research Foundation of China(21205131 ; Fundamental Research Funds for the Central Universities in China(GK201603099) ; Shanxi Province Agricultural Science and Technology Innovation ; Key Project(2016NY-181) ; Korea Health Industry Development Institute (KHIDI) - Ministry of Health and Welfare, Korea(H116C2129) ; 41406125)
URL查看原文
收录类别SCI
关键词[WOS]METHYLAMINO-L-ALANINE ; NEUROTOXIC AMINO-ACID ; CYANOBACTERIAL TOXINS ; SIGNAL AMPLIFICATION ; DEVICE ; MICROSPHERES ; COOCCURRENCE ; RECOGNITION ; POPULATIONS ; BIOASSAYS
文章类型Article
语种英语
WOS研究方向Chemistry ; Science & Technology - Other Topics
WOS记录号WOS:000395047000009
引用统计
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/22072
专题中科院海岸带环境过程与生态修复重点实验室
通讯作者Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China.; Choo, J (reprint author), Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea.; Chen, LX (reprint author), Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China. jbchoo@hanyang.ac.kr; lxchen@yic.ac.cn
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian 710119, Peoples R China
3.Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea
4.Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China
第一作者单位中国科学院烟台海岸带研究所
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Li, Bowei,Zhang, Zhong,Qi, Ji,et al. Quantum Dot-Based Molecularly Imprinted Polymers on Three-Dimensional Origami Paper Microfluidic Chip for Fluorescence Detection of Phycocyanin[J]. ACS SENSORS,2017,2(2):243-250.
APA Li, Bowei.,Zhang, Zhong.,Qi, Ji.,Zhou, Na.,Qin, Song.,...&lxchen@yic.ac.cn.(2017).Quantum Dot-Based Molecularly Imprinted Polymers on Three-Dimensional Origami Paper Microfluidic Chip for Fluorescence Detection of Phycocyanin.ACS SENSORS,2(2),243-250.
MLA Li, Bowei,et al."Quantum Dot-Based Molecularly Imprinted Polymers on Three-Dimensional Origami Paper Microfluidic Chip for Fluorescence Detection of Phycocyanin".ACS SENSORS 2.2(2017):243-250.
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