YIC-IR  > 海岸带生物学与生物资源保护实验室
Synthesis, Characterization, and the Antioxidant Activity of Double Quaternized Chitosan Derivatives
Wei, Lijie1,2; Li, Qing1; Tan, Wenqiang1,2; Dong, Fang1; Luan, Fang1,2; Guo, Zhanyong1,2; Li, Q; Guo, ZY (reprint author),Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China.; Guo, ZY (reprint author),Show the Organization-Enhanced name(s) Univ Chinese Acad Sci, Beijing 100049, Peoples R China. Email:qli@yic.ac.cn; zhanyongguo@hotmail.com
2017-03-01
Source PublicationMOLECULES
ISSN1420-3049
Volume22Issue:3Pages:501
Contribution Rank[Wei, Lijie; Li, Qing; Tan, Wenqiang; Dong, Fang; Luan, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Wei, Lijie; Tan, Wenqiang; Luan, Fang; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
AbstractWith the specialty of improving the water solubility of chitosan, quaternary ammonium salts have broadened the application of this polysaccharide in food, medicine and pesticides. To identify the effect of quaternary ammonium salts' quantity, single quaternized chitosan N-phenmethyl-N,N-dimethyl chitosan (PDCS), double quaternized chitosan N-(1-pyridylmethyl-2-ylmethyl)-N,N-dimethyl chitosan (MP2MDCS), N-(1-pyridylmethyl-3-ylmethyl)-N,N-dimethyl chitosan (MP3MDCS), and N-(1-pyridylmethyl-4-ylmethyl)-N,N-dimethyl chitosan (MP4MDCS) were designed and synthesized successfully through chemical modification of chitosan. Besides, three kinds of antioxidant activities, including hydroxyl radicals, superoxide radicals, and 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radicals were tested in vitro. As shown in this paper, the scavenging ability was ranking in order of MP3MDC > MP4MDCS > MP2MDCS > PDCS > chitosan at 1.6 mg/mL in all assays. All double quaternary ammonium salts were better than chitosan or the single quaternary ammonium salt. In addition, MP3MDCS could scavenge hydroxyl radicals totally at 1.6 mg/mL. MP2MDCS and MP4MDCS with more than 90% scavenging indices both had great scavenging ability on hydroxyl radicals or DPPH radicals. Furthermore, these data demonstrated that the increasing number of the positive charge would improve the antioxidant property of chitosan derivatives, and the N-pyridinium position would influence the scavenging radical ability.
KeywordSingle Quaternized Chitosan Double Quaternized Chitosan Chemical Modification Antioxidant Activity
Department海岸带生物学与生物资源利用所重点实验室 
Subject AreaChemistry
DOI10.3390/molecules22030501
Funding OrganizationNational Natural Science Foundation of China(41576156) ; Shandong Province Science and Technology Development Plan(2015GSF121045) ; Yantai Science and Technology Development Plan(2015ZH078) ; Public Science and Technology Research Funds Projects of Oceans(201505022-3)
URL查看原文
Indexed BySCI
WOS KeywordRADICALS SCAVENGING ACTIVITY ; CARBOXYMETHYL CHITOSAN ; ANTIBACTERIAL ACTION ; DISEASE ; DESIGN ; CHITIN ; AGENT
SubtypeArticle
Language英语
WOS Research AreaChemistry
WOS IDWOS:000398743500159
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/22015
Collection海岸带生物学与生物资源保护实验室
Corresponding AuthorLi, Q; Guo, ZY (reprint author),Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China.; Guo, ZY (reprint author),Show the Organization-Enhanced name(s) Univ Chinese Acad Sci, Beijing 100049, Peoples R China. Email:qli@yic.ac.cn; zhanyongguo@hotmail.com
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wei, Lijie,Li, Qing,Tan, Wenqiang,et al. Synthesis, Characterization, and the Antioxidant Activity of Double Quaternized Chitosan Derivatives[J]. MOLECULES,2017,22(3):501.
APA Wei, Lijie.,Li, Qing.,Tan, Wenqiang.,Dong, Fang.,Luan, Fang.,...&zhanyongguo@hotmail.com.(2017).Synthesis, Characterization, and the Antioxidant Activity of Double Quaternized Chitosan Derivatives.MOLECULES,22(3),501.
MLA Wei, Lijie,et al."Synthesis, Characterization, and the Antioxidant Activity of Double Quaternized Chitosan Derivatives".MOLECULES 22.3(2017):501.
Files in This Item: Download All
File Name/Size DocType Version Access License
Synthesis, Character(1676KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wei, Lijie]'s Articles
[Li, Qing]'s Articles
[Tan, Wenqiang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wei, Lijie]'s Articles
[Li, Qing]'s Articles
[Tan, Wenqiang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wei, Lijie]'s Articles
[Li, Qing]'s Articles
[Tan, Wenqiang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Synthesis, Characterization, and the Antioxidant Activity of Double Quaternized Chitosan Derivatives.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.