[Tan, Wenqiang; Li, Qing; Dong, Fang; Zhang, Jingjing; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Tan, Wenqiang; Zhang, Jingjing; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Qiu, Shuai] Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
通讯作者:
Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. zhanyongguo@hotmail.com
作者部门:
海岸带生物学与生物资源利用所重点实验室
英文摘要:
Four novel 1,2,3-triazolium-functionalized starch derivatives were synthesized by N-alkylating the precursor starch derivatives with 1,2,3-triazole with iodomethane based on cuprous-catalyzed azide-alkyne cycloaddition (CuAAC). The detailed structural characterization was investigated by means of FTIR, UV-vis, H-1 NMR, and C-13 NMR spectra. The antifungal activities of starch derivatives against Colletotrichum lagenarium, Fusarium oxysporum, and Watermelon fusarium, were then assayed by hypha measurement in vitro. The fungicidal assessment revealed that compared with starch and starch derivatives with 1,2,3-triazole, 1,2,3-triazolium-functionalized starch derivatives displayed tremendously enhanced antifungal activity. Especially, the inhibitory indices of 6-(4-hydroxymethy1-3-methyl-1,2,3-triazolium1-yl)-6-deoxy starch iodine (2a) with against the tested plant threatening fungi attained 70% above at 1.0 mg/mL. It was also found that their antifungal activity profiles were dependent on the variation in alkyl chain length. As novel 1,2,3-triazolium-functionalized starch derivatives could be prepared efficiently and exhibited superduper antifungal activity, this synthetic strategy might provide an effective way and notion to prepare novel antifungal biomaterials. (C) 2016 Elsevier Ltd. All rights reserved.
研究领域[WOS]:
Chemistry
; Polymer Science
项目资助者:
National Natural Science Foundation of China(41576156)
; Shandong Province Science and Technology Development Plan(2015GSF121045)
; Yantai Science and Technology Development Plan(2015ZH078)
; Public Science and Technology Research Funds Projects of Ocean(201505022-3)
1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
Recommended Citation:
Tan, Wenqiang,Li, Qing,Dong, Fang,et al. Novel 1,2,3-triazolium-functionalized starch derivatives: Synthesis, characterization, and evaluation of antifungal property[J]. CARBOHYDRATE POLYMERS,2017,160:163-171.
