Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics

doi:10.1016/j.marpolbul.2016.08.066

	Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics
	Zhang, Ying ; Wu, Huifeng; Wei, Lei ; Xie, Zeping ; Guan, Bo; Zhang, Y (reprint author), Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China. zhangying@bzmc.edu.cn
发表期刊	MARINE POLLUTION BULLETIN
ISSN	0025-326X
	2017-01-15
卷号	114 期号:1 页码:84-89
关键词	Metabolic Profile Hypoxia Ruditapes Philippinarum Proton Nuclear Magnetic Resonance Metabolomics
DOI	10.1016/j.marpolbul.2016.08.066
产权排序	[Zhang, Ying; Xie, Zeping] Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China; [Wu, Huifeng; Wei, Lei; Guan, Bo] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
作者部门	中科院海岸带环境过程与生态修复重点实验室
英文摘要	Coastal hypoxia affects the survival, behavior, and reproduction of individual local marine organisms, and the abundance, biomass, and biodiversity of coastal ecosystems. In this study, we investigated the chronic effects of hypoxia on the metabolomics in the gills of Ruditapes (R.) philippinarum. The results indicated significant alterations in the metabolite profiles in the gills of the hypoxia-treated clams, in comparison with those maintained under normoxia. The levels of betaine, taurine, glycine, isoleucine, and alanine were significantly reduced, suggesting a disturbance of osmotic balance associated with hypoxia. Meanwhile, metabolites involved in energy metabolism, such as alanine and succinate, were also affected. Dramatic histopathological changes were observed in the gills and hepatopancreases of R. philippinarum grown in hypoxic waters, demonstrating tissue damages apparently caused by long-term exposure to hypoxia. Our findings suggest that hypoxia significantly affects the physiology of R. philippinarum, even at a sub-lethal level, and impedes health of the clams. (C) 2016 Elsevier Ltd. All rights reserved.
文章类型	Article
资助机构	National Natural Science Foundation of China(31402330) ; Binzhou Medical University(BY2014KYQD06)
收录类别	SCI
语种	英语
关键词[WOS]	VIBRIO-HARVEYI CHALLENGE ; MYTILUS-GALLOPROVINCIALIS ; DIFFERENTIAL RESPONSES ; TAPES-PHILIPPINARUM ; OXYGEN LEVELS ; 2 PEDIGREES ; DECUSSATUS ; ZOOPLANKTON ; ADAPTATIONS ; BIOMARKERS
研究领域[WOS]	Environmental Sciences & Ecology ; Marine & Freshwater Biology
WOS记录号	WOS:000392768900023
引用统计	被引频次：28[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/21934
专题	中国科学院海岸带环境过程与生态修复重点实验室
通讯作者	Zhang, Y (reprint author), Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China. zhangying@bzmc.edu.cn
作者单位	1.Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ying,Wu, Huifeng,Wei, Lei,et al. Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics[J]. MARINE POLLUTION BULLETIN,2017,114(1):84-89.
APA	Zhang, Ying,Wu, Huifeng,Wei, Lei,Xie, Zeping,Guan, Bo,&Zhang, Y .(2017).Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics.MARINE POLLUTION BULLETIN,114(1),84-89.
MLA	Zhang, Ying,et al."Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics".MARINE POLLUTION BULLETIN 114.1(2017):84-89.

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