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Title:
Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics
Author: Zhang, Ying1; Wu, Huifeng2; Wei, Lei2; Xie, Zeping1; Guan, Bo(管博)2
Source: MARINE POLLUTION BULLETIN
ISSN: 0025-326X
Issued Date: 2017-01-15
Volume: 114, Issue:1, Pages:84-89
Keyword: Metabolic profile ; Hypoxia ; Ruditapes philippinarum ; Proton nuclear magnetic resonance ; Metabolomics
DOI: 10.1016/j.marpolbul.2016.08.066
English Abstract: Coastal hypoxia affects the survival, behavior, and reproduction of individual local marine organisms, and the abundance, biomass, and biodiversity of coastal ecosystems. In this study, we investigated the chronic effects of hypoxia on the metabolomics in the gills of Ruditapes (R.) philippinarum. The results indicated significant alterations in the metabolite profiles in the gills of the hypoxia-treated clams, in comparison with those maintained under normoxia. The levels of betaine, taurine, glycine, isoleucine, and alanine were significantly reduced, suggesting a disturbance of osmotic balance associated with hypoxia. Meanwhile, metabolites involved in energy metabolism, such as alanine and succinate, were also affected. Dramatic histopathological changes were observed in the gills and hepatopancreases of R. philippinarum grown in hypoxic waters, demonstrating tissue damages apparently caused by long-term exposure to hypoxia. Our findings suggest that hypoxia significantly affects the physiology of R. philippinarum, even at a sub-lethal level, and impedes health of the clams. (C) 2016 Elsevier Ltd. All rights reserved.
WOS Subject Extended: Environmental Sciences & Ecology ; Marine & Freshwater Biology
Funder: National Natural Science Foundation of China(31402330) ; Binzhou Medical University(BY2014KYQD06)
WOS Keyword Plus: VIBRIO-HARVEYI CHALLENGE ; MYTILUS-GALLOPROVINCIALIS ; DIFFERENTIAL RESPONSES ; TAPES-PHILIPPINARUM ; OXYGEN LEVELS ; 2 PEDIGREES ; DECUSSATUS ; ZOOPLANKTON ; ADAPTATIONS ; BIOMARKERS
DOC Type: Article
Indexed Type: SCI
Language: 英语
WOS ID: WOS:000392768900023
Citation statistics:
Content Type: 期刊论文
URI: http://ir.yic.ac.cn/handle/133337/21934
Appears in Collections:中科院海岸带环境过程与生态修复重点实验室_期刊论文

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description.institution: 1.Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China

Recommended Citation:
Zhang, Ying,Wu, Huifeng,Wei, Lei,et al. Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics[J]. MARINE POLLUTION BULLETIN,2017,114(1):84-89.
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