YIC-IR  > 中科院海岸带环境过程与生态修复重点实验室
Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics
Zhang, Ying; Wu, Huifeng; Wei, Lei; Xie, Zeping; Guan, Bo; Zhang, Y (reprint author), Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China. zhangying@bzmc.edu.cn
2017-01-15
Source PublicationMARINE POLLUTION BULLETIN
ISSN0025-326X
Volume114Issue:1Pages:84-89
Contribution Rank[Zhang, Ying; Xie, Zeping] Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China; [Wu, Huifeng; Wei, Lei; Guan, Bo] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
AbstractCoastal hypoxia affects the survival, behavior, and reproduction of individual local marine organisms, and the abundance, biomass, and biodiversity of coastal ecosystems. In this study, we investigated the chronic effects of hypoxia on the metabolomics in the gills of Ruditapes (R.) philippinarum. The results indicated significant alterations in the metabolite profiles in the gills of the hypoxia-treated clams, in comparison with those maintained under normoxia. The levels of betaine, taurine, glycine, isoleucine, and alanine were significantly reduced, suggesting a disturbance of osmotic balance associated with hypoxia. Meanwhile, metabolites involved in energy metabolism, such as alanine and succinate, were also affected. Dramatic histopathological changes were observed in the gills and hepatopancreases of R. philippinarum grown in hypoxic waters, demonstrating tissue damages apparently caused by long-term exposure to hypoxia. Our findings suggest that hypoxia significantly affects the physiology of R. philippinarum, even at a sub-lethal level, and impedes health of the clams. (C) 2016 Elsevier Ltd. All rights reserved.
KeywordMetabolic Profile Hypoxia Ruditapes Philippinarum Proton Nuclear Magnetic Resonance Metabolomics
Department中科院海岸带环境过程与生态修复重点实验室
DOI10.1016/j.marpolbul.2016.08.066
Funding OrganizationNational Natural Science Foundation of China(31402330) ; Binzhou Medical University(BY2014KYQD06)
Indexed BySCI
WOS KeywordVIBRIO-HARVEYI CHALLENGE ; MYTILUS-GALLOPROVINCIALIS ; DIFFERENTIAL RESPONSES ; TAPES-PHILIPPINARUM ; OXYGEN LEVELS ; 2 PEDIGREES ; DECUSSATUS ; ZOOPLANKTON ; ADAPTATIONS ; BIOMARKERS
SubtypeArticle
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Marine & Freshwater Biology
WOS IDWOS:000392768900023
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/21934
Collection中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorZhang, Y (reprint author), Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China. zhangying@bzmc.edu.cn
Affiliation1.Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ying,Wu, Huifeng,Wei, Lei,et al. Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics[J]. MARINE POLLUTION BULLETIN,2017,114(1):84-89.
APA Zhang, Ying,Wu, Huifeng,Wei, Lei,Xie, Zeping,Guan, Bo,&Zhang, Y .(2017).Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics.MARINE POLLUTION BULLETIN,114(1),84-89.
MLA Zhang, Ying,et al."Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics".MARINE POLLUTION BULLETIN 114.1(2017):84-89.
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