Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics
Zhang, Ying; Wu, Huifeng; Wei, Lei; Xie, Zeping; Guan, Bo; Zhang, Y (reprint author), Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China. zhangying@bzmc.edu.cn
2017-01-15
发表期刊MARINE POLLUTION BULLETIN
ISSN0025-326X
卷号114期号:1页码:84-89
产权排序[Zhang, Ying; Xie, Zeping] Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China; [Wu, Huifeng; Wei, Lei; Guan, Bo] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
摘要Coastal hypoxia affects the survival, behavior, and reproduction of individual local marine organisms, and the abundance, biomass, and biodiversity of coastal ecosystems. In this study, we investigated the chronic effects of hypoxia on the metabolomics in the gills of Ruditapes (R.) philippinarum. The results indicated significant alterations in the metabolite profiles in the gills of the hypoxia-treated clams, in comparison with those maintained under normoxia. The levels of betaine, taurine, glycine, isoleucine, and alanine were significantly reduced, suggesting a disturbance of osmotic balance associated with hypoxia. Meanwhile, metabolites involved in energy metabolism, such as alanine and succinate, were also affected. Dramatic histopathological changes were observed in the gills and hepatopancreases of R. philippinarum grown in hypoxic waters, demonstrating tissue damages apparently caused by long-term exposure to hypoxia. Our findings suggest that hypoxia significantly affects the physiology of R. philippinarum, even at a sub-lethal level, and impedes health of the clams. (C) 2016 Elsevier Ltd. All rights reserved.
关键词Metabolic Profile Hypoxia Ruditapes Philippinarum Proton Nuclear Magnetic Resonance Metabolomics
作者部门中科院海岸带环境过程与生态修复重点实验室
DOI10.1016/j.marpolbul.2016.08.066
项目资助者National Natural Science Foundation of China(31402330) ; Binzhou Medical University(BY2014KYQD06)
收录类别SCI
关键词[WOS]VIBRIO-HARVEYI CHALLENGE ; MYTILUS-GALLOPROVINCIALIS ; DIFFERENTIAL RESPONSES ; TAPES-PHILIPPINARUM ; OXYGEN LEVELS ; 2 PEDIGREES ; DECUSSATUS ; ZOOPLANKTON ; ADAPTATIONS ; BIOMARKERS
文章类型Article
语种英语
WOS研究方向Environmental Sciences & Ecology ; Marine & Freshwater Biology
WOS记录号WOS:000392768900023
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/21934
专题中科院海岸带环境过程与生态修复重点实验室
通讯作者Zhang, Y (reprint author), Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China. zhangying@bzmc.edu.cn
作者单位1.Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
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GB/T 7714
Zhang, Ying,Wu, Huifeng,Wei, Lei,et al. Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics[J]. MARINE POLLUTION BULLETIN,2017,114(1):84-89.
APA Zhang, Ying,Wu, Huifeng,Wei, Lei,Xie, Zeping,Guan, Bo,&Zhang, Y .(2017).Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics.MARINE POLLUTION BULLETIN,114(1),84-89.
MLA Zhang, Ying,et al."Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics".MARINE POLLUTION BULLETIN 114.1(2017):84-89.
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