| A Protein-Polymer Bioconjugate-Coated Upconversion Nanosystem for Simultaneous Tumor Cell Imaging, Photodynamic Therapy, and Chemotherapy | |
| Dong, Chunhong; Liu, Zhongyun; Wang, Sheng; Zheng, Bin; Guo, Weisheng; Yang, Weitao; Gong, Xiaoqun; Wu, Xiaoli; Wang, Hanjie; Chang, Jin; Wang, HJ | |
| 发表期刊 | ACS APPLIED MATERIALS & INTERFACES
 |
| ISSN | 1944-8244 |
| 2016-12-07 | |
| 卷号 | 8期号:48页码:32688-32698 |
| 关键词 | Upconversion Nanosystems Protein-polymer Bioconjugate Combined Therapy Chemotherapy Photodynamic Therapy |
| DOI | 10.1021/acsami.6b11803 |
| 产权排序 | [Dong, Chunhong; Wang, Sheng; Zheng, Bin; Guo, Weisheng; Yang, Weitao; Gong, Xiaoqun; Wu, Xiaoli; Wang, Hanjie; Chang, Jin] Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin Engn Ctr Micro Nano Biomat & Detect Treat, Sch Mat Sci & Engn,Sch Life Sci, Tianjin 300072, Peoples R China; [Liu, Zhongyun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Processes & Ecol Remedia, Yantai 264003, Shandong, Peoples R China |
| 作者部门 | 山东省海岸带环境工程技术研究中心 |
| 英文摘要 | Combined cancer therapy possesses many advantages including improved tumoricidal efficacy, reduced side effects, and retarded drug resistance. Herein, a protein-polymer bioconjugate-coated multifunctional upconversion nanosystem, consisting of upconversion nanoparticles (UCNs) core, tailored amphiphilic protein-polymer bioconjugate shell, and photosensitizer zinc phthalocyanine (ZnPc) and antitumor drug doxorubicin coloaded inside, was elaborately developed for combined photodynamic therapy (PDT) and chemotherapy. In this system, UCNs core could convert deep penetrating near infrared light to visible light for simultaneous cell fluorescence imaging and photodynamic therapy by activating ZnPc to generate cytotoxic ROS, while the protective shell of bovine serum albumin-poly(e-caprolactone) (BSA-PCL) offered excellent water solubility, good stability, and low cytotoxicity. The ROS production test showed that this nanosystem could successfully generate singlet oxygen under NIR irradiation. A cellular uptake study demonstrated that intense fluorescence emission of the UCNs could be observed in HeLa cells, indicating their outstanding real-time imaging capability. More importantly, compared with single PDT or chemotherapy systems, the constructed combined therapy UCNs system demonstrated significantly enhanced tumor cell killing efficiency. On the basis of our findings, this multifunctional UCNs nanosystem could be a promising versatile theranostic nanoplatform for image-guided combined cancer therapy. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of China(51373117 ; Key Project of Tianjin Natural Science Foundation(13JCZDJC33200 ; National High Technology Program of China(2012AA022603) ; Doctoral Base Foundation of Educational Ministry of China(20120032110027) ; 51573128 ; 15JCQNJC03100) ; 51303126) |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | DRUG-DELIVERY ; FLUORESCENCE NANOPROBE ; COMBINATION THERAPY ; CANCER-THERAPY ; NANOPARTICLES ; NANOCOMPOSITES ; NANOMEDICINE ; NANOCARRIER ; RELEASE |
| 研究领域[WOS] | Science & Technology - Other Topics ; Materials Science |
| WOS记录号 | WOS:000389624600009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/19272 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心 |
| 通讯作者 | Wang, HJ |
| 作者单位 | 1.Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin Engn Ctr Micro Nano Biomat & Detect Treat, Sch Mat Sci & Engn,Sch Life Sci, Tianjin 300072, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Processes & Ecol Remedia, Yantai 264003, Shandong, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Processes & Ecol Remedia, Yantai 264003, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Chunhong,Liu, Zhongyun,Wang, Sheng,et al. A Protein-Polymer Bioconjugate-Coated Upconversion Nanosystem for Simultaneous Tumor Cell Imaging, Photodynamic Therapy, and Chemotherapy[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(48):32688-32698. |
| APA | Dong, Chunhong.,Liu, Zhongyun.,Wang, Sheng.,Zheng, Bin.,Guo, Weisheng.,...&Wang, HJ.(2016).A Protein-Polymer Bioconjugate-Coated Upconversion Nanosystem for Simultaneous Tumor Cell Imaging, Photodynamic Therapy, and Chemotherapy.ACS APPLIED MATERIALS & INTERFACES,8(48),32688-32698. |
| MLA | Dong, Chunhong,et al."A Protein-Polymer Bioconjugate-Coated Upconversion Nanosystem for Simultaneous Tumor Cell Imaging, Photodynamic Therapy, and Chemotherapy".ACS APPLIED MATERIALS & INTERFACES 8.48(2016):32688-32698. |
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