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A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging
其他题名A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging
Dong, CH; Liu, ZY; Liu, JQ; Wu, CZ; Neumann, F; Wang, HJ; Schafer-Korting, M; Kleuser, B; Chang, J; Li, WZ; Ma, N; Haag, R; Chang, J (reprint author), Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin Engn Ctr Micronano Biomat & Detect Treatm, Sch Life Sci,Sch Mat Sci & Engn, Tianjin 300072, Peoples R China.; Haag, R (reprint author), Free Univ Berlin, Inst Chem & Biochem, Takustr 3, D-14195 Berlin, Germany.; Ma, N (reprint author), Helmholtz Zentrum Geesthacht, Inst Biomat Res, Kantstr 55, D-14513 Teltow, Germany. Email:jinchang@tju.edu.cn; nan.ma@hzg.de; haag@chemie.fu-berlin.de
2016-09-07
发表期刊ADVANCED HEALTHCARE MATERIALS
ISSN2192-2640
卷号5期号:17页码:2214-2226
产权排序[Dong, Chunhong; Liu, Junqing; Wang, Hanjie; Chang, Jin] Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin Engn Ctr Micronano Biomat & Detect Treatm, Sch Life Sci,Sch Mat Sci & Engn, Tianjin 300072, Peoples R China; [Liu, Zhongyun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol Shandong, Yantai 264003, Shandong, Peoples R China; [Wu, Changzhu; Neumann, Falko; Ma, Nan; Haag, Rainer] Free Univ Berlin, Inst Chem & Biochem, Takustr 3, D-14195 Berlin, Germany; [Schaefer-Korting, Monika] Free Univ Berlin, Inst Pharm, Konigin Luise Str 2-4, D-14195 Berlin, Germany; [Kleuser, Burkhard] Univ Potsdam, Inst Ernahrungswissensch, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany; [Li, Wenzhong] Univ Rostock, Reference & Translat Ctr Cardiac Stem Cell Therap, Schillingallee 69, D-18057 Rostock, Germany; [Ma, Nan] Helmholtz Zentrum Geesthacht, Inst Biomat Res, Kantstr 55, D-14513 Teltow, Germany
摘要Considering the critical role of mitochondria in the life and death of cells, non-invasive long-term tracking of mitochondria has attracted considerable interest. However, a high-performance mitochondria-specific labeling probe with high photostability is still lacking. Herein a highly photostable hyperbranched polyglycerol (hPG)-based near-infrared (NIR) quantum dots (QDs) nanoplatform is reported for mitochondria-specific cell imaging. Comprising NIR Zn-Cu-In-S/ZnS QDs as extremely photostable fluorescent labels and alkyl chain (C-12)/triphenylphosphonium (TPP)-functionalized hPG derivatives as protective shell, the tailored QDs@hPG-C-12/TPP nanoprobe with a hydrodynamic diameter of about 65 nm exhibits NIR fluorescence, excellent biocompatibility, good stability, and mitochondria-targeted ability. Cell uptake experiments demonstrate that QDs@hPG-C-12/TPP displays a significantly enhanced uptake in HeLa cells compared to nontargeted QDs@hPG-C-12. Further co-localization study indicates that the probe selectively targets mitochondria. Importantly, compared with commercial deep-red mitochondria dyes, QDs@hPG-C-12/TPP possesses superior photostability under continuous laser irradiation, indicating great potential for long-term mitochondria labeling and tracking. Moreover, drug-loaded QDs@hPG-C-12/TPP display an enhanced tumor cell killing efficacy compared to nontargeted drugs. This work could open the door to the construction of organelle-targeted multifunctional nanoplatforms for precise diagnosis and high-efficient tumor therapy.
关键词Hyperbranched Polyglycerol Mitochondria Targeting Nir Zcis Zns Qds Photostability Tumor Theranostics
作者部门山东省海岸带环境工程技术研究中心
学科领域Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, bioMaterials
DOI10.1002/adhm.201600212
项目资助者National Natural Science Foundation of China [51373117, 51573128, 51303126] ; Key Project of Tianjin Natural Science Foundation [13JCZDJC33200, 15JCQNJC03100] ; National High Technology Program of China [2012AA022603] ; Doctoral Base Foundation of the Educational Ministry of China [20120032110027] ; [SFB 1112]
收录类别SCI
关键词[WOS]WALLED CARBON NANOTUBES ; CANCER-CELLS ; TARGETED DELIVERY ; QUANTUM DOTS ; POLY(AMIDOAMINE) DENDRIMERS ; DRUG-DELIVERY ; NANOPARTICLE ; THERAPY ; DOXORUBICIN ; NANOPROBE
文章类型Article
语种英语
WOS研究方向Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS记录号WOS:000383776300008
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/17489
专题山东省海岸带环境工程技术研究中心
海岸带生物学与生物资源利用所重点实验室
通讯作者Ma, N; Chang, J (reprint author), Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin Engn Ctr Micronano Biomat & Detect Treatm, Sch Life Sci,Sch Mat Sci & Engn, Tianjin 300072, Peoples R China.; Haag, R (reprint author), Free Univ Berlin, Inst Chem & Biochem, Takustr 3, D-14195 Berlin, Germany.; Ma, N (reprint author), Helmholtz Zentrum Geesthacht, Inst Biomat Res, Kantstr 55, D-14513 Teltow, Germany. Email:jinchang@tju.edu.cn; nan.ma@hzg.de; haag@chemie.fu-berlin.de
作者单位1.Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin Engn Ctr Micronano Biomat & Detect Treatm, Sch Life Sci,Sch Mat Sci & Engn
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol Shandong
3.Free Univ Berlin, Inst Chem & Biochem
4.Free Univ Berlin, Inst Pharm
5.Univ Potsdam, Inst Ernahrungswissensch
6.Univ Rostock, Reference & Translat Ctr Cardiac Stem Cell Therap
7.Helmholtz Zentrum Geesthacht, Inst Biomat Res
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Dong, CH,Liu, ZY,Liu, JQ,et al. A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging[J]. ADVANCED HEALTHCARE MATERIALS,2016,5(17):2214-2226.
APA Dong, CH.,Liu, ZY.,Liu, JQ.,Wu, CZ.,Neumann, F.,...&haag@chemie.fu-berlin.de.(2016).A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging.ADVANCED HEALTHCARE MATERIALS,5(17),2214-2226.
MLA Dong, CH,et al."A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging".ADVANCED HEALTHCARE MATERIALS 5.17(2016):2214-2226.
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