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题名:
A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing
作者: Ding, JW; Li BoWei(李博伟); Chen, LX; Wei Qin(秦伟)
刊名: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN号: 1433-7851
出版日期: 2016-10-10
卷号: 55, 期号:42, 页码:13033-13037
关键词: biosensors ; enzyme-based assays ; origami paper-based devices ; potentiometry
DOI: 10.1002/anie.201606268
产权排序: [Ding, Jiawang; Li, Bowei; Chen, Lingxin; Qin, Wei] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China; [Ding, Jiawang; Li, Bowei; Chen, Lingxin; Qin, Wei] YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China
通讯作者: Qin, W (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China. ; Qin, W (reprint author), YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China. Email:wqin@yic.ac.cn
作者部门: 中科院海岸带环境过程与生态修复重点实验室
英文摘要: Current paper-based potentiometric ion-sensing platforms are planar devices used for clinically relevant ions. These devices, however, have not been designed for the potentiometric biosensing of proteins or small molecule analytes. A three-dimensional origami paper-based device, in which a solid-contact ion-selective electrode is integrated with an all-solid-state reference electrode, is described for the first time. The device is made by impregnation of paper with appropriate bioreceptors and reporting reagents on different zones. By folding and unfolding the paper structures, versatile potentiometric bioassays can be performed. A USB-controlled miniaturized electrochemical detector can be used for simple and in situ measurements. Using butyrylcholinesterase as a model enzyme, the device has been successfully applied to the detection of enzyme activities and organophosphate pesticides involved in the enzymatic system as inhibitors. The proposed 3D origami paper device allows the potentiometric biosensing of proteins and small molecules in a simple, portable, and cost-effective way.
研究领域[WOS]: Chemistry
项目资助者: National Natural Science Foundation of China(21575158 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA11020702) ; Youth Innovation Promotion Association of CAS(2013139) ; Taishan Scholar Program of Shandong Province ; 21475148 ; 21205131)
关键词[WOS]: ION-SELECTIVE ELECTRODES ; SOLID-CONTACT ; ELECTROANALYTICAL DEVICES ; ELECTROCHEMICAL DETECTION ; MICROFLUIDIC DEVICES ; MEMBRANE ELECTRODES ; CARBON NANOTUBES ; DETECTION LIMITS ; SENSORS ; PLATFORM
文章类型: Article
收录类别: SCI
语种: 英语
WOS记录号: WOS:000385799200013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.yic.ac.cn/handle/133337/17468
Appears in Collections:中科院海岸带环境过程与生态修复重点实验室_期刊论文

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Recommended Citation:
Ding, JW,Li, BW,Chen, LX,et al. A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(42):13033-13037.
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文件名: A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing.pdf
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