A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing
Ding, JW; Li, BW; Chen, LX; Qin, W; Qin, W (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China.; Qin, W (reprint author), YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China. Email:wqin@yic.ac.cn
2016-10-10
发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
卷号55期号:42页码:13033-13037
产权排序[Ding, Jiawang; Li, Bowei; Chen, Lingxin; Qin, Wei] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China; [Ding, Jiawang; Li, Bowei; Chen, Lingxin; Qin, Wei] YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China
摘要Current paper-based potentiometric ion-sensing platforms are planar devices used for clinically relevant ions. These devices, however, have not been designed for the potentiometric biosensing of proteins or small molecule analytes. A three-dimensional origami paper-based device, in which a solid-contact ion-selective electrode is integrated with an all-solid-state reference electrode, is described for the first time. The device is made by impregnation of paper with appropriate bioreceptors and reporting reagents on different zones. By folding and unfolding the paper structures, versatile potentiometric bioassays can be performed. A USB-controlled miniaturized electrochemical detector can be used for simple and in situ measurements. Using butyrylcholinesterase as a model enzyme, the device has been successfully applied to the detection of enzyme activities and organophosphate pesticides involved in the enzymatic system as inhibitors. The proposed 3D origami paper device allows the potentiometric biosensing of proteins and small molecules in a simple, portable, and cost-effective way.
关键词Biosensors Enzyme-based Assays Origami Paper-based Devices Potentiometry
作者部门中科院海岸带环境过程与生态修复重点实验室
DOI10.1002/anie.201606268
项目资助者National Natural Science Foundation of China(21575158 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA11020702) ; Youth Innovation Promotion Association of CAS(2013139) ; Taishan Scholar Program of Shandong Province ; 21475148 ; 21205131)
收录类别SCI
关键词[WOS]ION-SELECTIVE ELECTRODES ; SOLID-CONTACT ; ELECTROANALYTICAL DEVICES ; ELECTROCHEMICAL DETECTION ; MICROFLUIDIC DEVICES ; MEMBRANE ELECTRODES ; CARBON NANOTUBES ; DETECTION LIMITS ; SENSORS ; PLATFORM
文章类型Article
语种英语
WOS研究方向Chemistry
WOS记录号WOS:000385799200013
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/17468
专题中科院海岸带环境过程与生态修复重点实验室
通讯作者Qin, W (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China.; Qin, W (reprint author), YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China. Email:wqin@yic.ac.cn
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GB/T 7714
Ding, JW,Li, BW,Chen, LX,et al. A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(42):13033-13037.
APA Ding, JW,Li, BW,Chen, LX,Qin, W,Qin, W ,&Qin, W .(2016).A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(42),13033-13037.
MLA Ding, JW,et al."A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.42(2016):13033-13037.
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