A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing

doi:10.1002/anie.201606268

	A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing
	Ding, JW; Li, BW; Chen, LX; Qin, W; Qin, W (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China.; Qin, W (reprint author), YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China. Email:wqin@yic.ac.cn
发表期刊	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN	1433-7851
	2016-10-10
卷号	55 期号:42 页码:13033-13037
关键词	Biosensors Enzyme-based Assays Origami Paper-based Devices Potentiometry
DOI	10.1002/anie.201606268
产权排序	[Ding, Jiawang; Li, Bowei; Chen, Lingxin; Qin, Wei] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China; [Ding, Jiawang; Li, Bowei; Chen, Lingxin; Qin, Wei] YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China
作者部门	中科院海岸带环境过程与生态修复重点实验室
英文摘要	Current paper-based potentiometric ion-sensing platforms are planar devices used for clinically relevant ions. These devices, however, have not been designed for the potentiometric biosensing of proteins or small molecule analytes. A three-dimensional origami paper-based device, in which a solid-contact ion-selective electrode is integrated with an all-solid-state reference electrode, is described for the first time. The device is made by impregnation of paper with appropriate bioreceptors and reporting reagents on different zones. By folding and unfolding the paper structures, versatile potentiometric bioassays can be performed. A USB-controlled miniaturized electrochemical detector can be used for simple and in situ measurements. Using butyrylcholinesterase as a model enzyme, the device has been successfully applied to the detection of enzyme activities and organophosphate pesticides involved in the enzymatic system as inhibitors. The proposed 3D origami paper device allows the potentiometric biosensing of proteins and small molecules in a simple, portable, and cost-effective way.
文章类型	Article
资助机构	National Natural Science Foundation of China(21575158 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA11020702) ; Youth Innovation Promotion Association of CAS(2013139) ; Taishan Scholar Program of Shandong Province ; 21475148 ; 21205131)
收录类别	SCI
语种	英语
关键词[WOS]	ION-SELECTIVE ELECTRODES ; SOLID-CONTACT ; ELECTROANALYTICAL DEVICES ; ELECTROCHEMICAL DETECTION ; MICROFLUIDIC DEVICES ; MEMBRANE ELECTRODES ; CARBON NANOTUBES ; DETECTION LIMITS ; SENSORS ; PLATFORM
研究领域[WOS]	Chemistry
WOS记录号	WOS:000385799200013
引用统计	被引频次：133[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/17468
专题	中国科学院海岸带环境过程与生态修复重点实验室
通讯作者	Qin, W (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China.; Qin, W (reprint author), YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China. Email:wqin@yic.ac.cn
推荐引用方式 GB/T 7714	Ding, JW,Li, BW,Chen, LX,et al. A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(42):13033-13037.
APA	Ding, JW,Li, BW,Chen, LX,Qin, W,Qin, W ,&Qin, W .(2016).A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(42),13033-13037.
MLA	Ding, JW,et al."A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.42(2016):13033-13037.

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