| Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189 | |
Gao, SS; Li, XM; Williams, K; Proksch, P; Ji, NY ; Wang, BG; Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Lab Marine Biol & Biotechnol,Qingdao Natl Lab Mar, Nanhai Rd 7, Qingdao 266071, Peoples R China.; Proksch, P (reprint author), Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany.; Ji, NY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China. Email:proksch@uni-duesseldorf.de; nyji@yic.ac.cn; wangbg@ms.qdio.ac.cn
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| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 2016-08-01 | |
| 卷号 | 79期号:8页码:2066-2074 |
| DOI | 10.1021/acs.jnatprod.6b00403 |
| 产权排序 | [Gao, Shu-Shan; Li, Xiao-Ming; Wang, Bin-Gui] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Lab Marine Biol & Biotechnol,Qingdao Natl Lab Mar, Nanhai Rd 7, Qingdao 266071, Peoples R China; [Gao, Shu-Shan; Williams, Katherine] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England; [Proksch, Peter] Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany; [Ji, Nai-Yun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China |
| 作者部门 | 海岸带生物学与生物资源利用所重点实验室 |
| 英文摘要 | Genome mining of the fungus Mucor irregularis (formerly known as Rhizomucor variabilis) revealed the presence of various gene clusters for secondary metabolite biosynthesis, including several terpene-based clusters. Investigation into the chemical diversity of M. irregularis QEN-189, an endophytic fungus isolated from the fresh inner tissue of the marine mangrove plant Rhizophora stylosa, resulted in the discovery of 20 structurally diverse indole-diterpenes including six new compounds, namely, rhizovarins A-F (1-6). Among them, compounds 1-3 represent the most complex members of the reported indole-diterpenes. The presence of an unusual acetal linked to a hemiketal (1) or a ketal (2 and 3) in an unprecedented 4,6,6,8,5,6,6,6,6-fused indole-diterpene ring system makes them chemically unique. Their structures and absolute configurations were elucidated by spectroscopic analysis, modified Mosher's method, and chemical calculations. Each of the isolated compounds was evaluated for antitumor activity against HL-60 and A-549 cell lines. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of China (NSFC)(31570356) ; NSFC-Shandong Joint Fund for Marine Science Research Centers(U1406402) ; Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology(2015ASKJ02) ; Taishan Scholar Project from Shandong Province |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | TREMORGENIC MYCO-TOXINS ; PENICILLIUM-CRUSTOSUM THOM ; STRUCTURE ELUCIDATION ; ABSOLUTE-CONFIGURATION ; ASPERGILLUS-SULPHUREUS ; EMERICELLA-STRIATA ; PENITREM-A ; ALKALOIDS ; PAXILLINE ; INDOLODITERPENES |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:000382274700019 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/17130 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 通讯作者 | Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Lab Marine Biol & Biotechnol,Qingdao Natl Lab Mar, Nanhai Rd 7, Qingdao 266071, Peoples R China.; Proksch, P (reprint author), Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany.; Ji, NY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China. Email:proksch@uni-duesseldorf.de; nyji@yic.ac.cn; wangbg@ms.qdio.ac.cn |
| 推荐引用方式 GB/T 7714 | Gao, SS,Li, XM,Williams, K,et al. Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(8):2066-2074. |
| APA | Gao, SS.,Li, XM.,Williams, K.,Proksch, P.,Ji, NY.,...&wangbg@ms.qdio.ac.cn.(2016).Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189.JOURNAL OF NATURAL PRODUCTS,79(8),2066-2074. |
| MLA | Gao, SS,et al."Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189".JOURNAL OF NATURAL PRODUCTS 79.8(2016):2066-2074. |
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| Rhizovarins A-F, Ind（1780KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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