Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
| Proteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis | |
Yu, DL; Ji, CL ; Zhao, JM; Wu, HF; Wu, HF (reprint author), Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
| |
| 发表期刊 | CHEMOSPHERE
 |
| ISSN | 0045-6535 |
| 2016-05-01 | |
| 卷号 | 150页码:194-201 |
| 关键词 | Mytilus Galloprovincialis Arsenic Toxicological Effects Metabolomics Proteomics |
| DOI | 10.1016/j.chemosphere.2016.01.113 |
| 产权排序 | [Yu, Deliang; Ji, Chenglong; Zhao, Jianmin; Wu, Huifeng] Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Peoples R China; [Yu, Deliang] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 作者部门 | 中科院海岸带环境过程与生态修复重点实验室 |
| 英文摘要 | Inorganic arsenic (As) is a known pollutant including two chemical forms (arsenite (As III) and arsenate (As V)), in marine and coastal environment. Marine mussel Mytilus galloprovincialis is an important environmental monitoring species around the world. In this study, we focused on valence-specific responses of As in juvenile mussel M. galloprovincialis using a combined proteomic and metabolomic approach. Metabolic responses indicated that As (III) mainly caused disturbance in osmotic regulation in juvenile mussels. As (V) caused disturbances in both osmotic regulation and energy metabolism marked by different metabolic responses, including betaine, taurine, glucose and glycogen. Proteomic responses exhibited that As (III) had a significant negative effect on cytoskeleton and cell structure (actin and collagen alpha-6(VI) chain). As (V) affected some key enzymes involved in energy metabolism (cytosolic malate dehydrogenase, cMDH) and cell development (ornithine aminotransferase and astacin). Overall, all these results confirmed the valence-specific responses in juvenile mussels to As exposures. These findings demonstrate that a combined metabolomic and proteomic approach could provide an important insight into the toxicological effects of environmental pollutants in organisms. (C) 2016 Elsevier Ltd. All rights reserved. |
| 文章类型 | Article |
| 资助机构 | National Key Basic Research Program of China(2015CB453303) ; Natural Science Foundation of Shandong Province(JQ201310) ; National Natural Science Foundation of China(41206105) |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | OYSTER CRASSOSTREA-GIGAS ; MALATE-DEHYDROGENASES ; ELEVATED PCO(2) ; TRACE-METALS ; EXPOSURE ; NMR ; TOXICITY ; PROTEINS ; STRESS ; HEALTH |
| 研究领域[WOS] | Environmental Sciences & Ecology |
| WOS记录号 | WOS:000372765100025 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/17027 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 通讯作者 | Wu, HF (reprint author), Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Peoples R China. hfwu@yic.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS 2.Univ Chinese Acad Sci |
| 推荐引用方式 GB/T 7714 | Yu, DL,Ji, CL,Zhao, JM,et al. Proteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis[J]. CHEMOSPHERE,2016,150:194-201. |
| APA | Yu, DL,Ji, CL,Zhao, JM,Wu, HF,&Wu, HF .(2016).Proteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis.CHEMOSPHERE,150,194-201. |
| MLA | Yu, DL,et al."Proteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis".CHEMOSPHERE 150(2016):194-201. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Proteomic and metabo（1335KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
| 个性服务 |
| 推荐该条目 |
| 保存到收藏夹 |
| 查看访问统计 |
| 导出为Endnote文件 |
| 谷歌学术 |
| 谷歌学术中相似的文章 |
| [Yu, DL]的文章 |
| [Ji, CL]的文章 |
| [Zhao, JM]的文章 |
| 百度学术 |
| 百度学术中相似的文章 |
| [Yu, DL]的文章 |
| [Ji, CL]的文章 |
| [Zhao, JM]的文章 |
| 必应学术 |
| 必应学术中相似的文章 |
| [Yu, DL]的文章 |
| [Ji, CL]的文章 |
| [Zhao, JM]的文章 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论