YIC-IR  > 中科院海岸带环境过程与生态修复重点实验室
Proteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis
Yu, DL; Ji, CL; Zhao, JM; Wu, HF; Wu, HF (reprint author), Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
2016-05-01
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume150Pages:194-201
Contribution Rank[Yu, Deliang; Ji, Chenglong; Zhao, Jianmin; Wu, Huifeng] Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Peoples R China; [Yu, Deliang] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
AbstractInorganic arsenic (As) is a known pollutant including two chemical forms (arsenite (As III) and arsenate (As V)), in marine and coastal environment. Marine mussel Mytilus galloprovincialis is an important environmental monitoring species around the world. In this study, we focused on valence-specific responses of As in juvenile mussel M. galloprovincialis using a combined proteomic and metabolomic approach. Metabolic responses indicated that As (III) mainly caused disturbance in osmotic regulation in juvenile mussels. As (V) caused disturbances in both osmotic regulation and energy metabolism marked by different metabolic responses, including betaine, taurine, glucose and glycogen. Proteomic responses exhibited that As (III) had a significant negative effect on cytoskeleton and cell structure (actin and collagen alpha-6(VI) chain). As (V) affected some key enzymes involved in energy metabolism (cytosolic malate dehydrogenase, cMDH) and cell development (ornithine aminotransferase and astacin). Overall, all these results confirmed the valence-specific responses in juvenile mussels to As exposures. These findings demonstrate that a combined metabolomic and proteomic approach could provide an important insight into the toxicological effects of environmental pollutants in organisms. (C) 2016 Elsevier Ltd. All rights reserved.
KeywordMytilus Galloprovincialis Arsenic Toxicological Effects Metabolomics Proteomics
Department中科院海岸带环境过程与生态修复重点实验室
DOI10.1016/j.chemosphere.2016.01.113
Funding OrganizationNational Key Basic Research Program of China(2015CB453303) ; Natural Science Foundation of Shandong Province(JQ201310) ; National Natural Science Foundation of China(41206105)
Indexed BySCI
WOS KeywordOYSTER CRASSOSTREA-GIGAS ; MALATE-DEHYDROGENASES ; ELEVATED PCO(2) ; TRACE-METALS ; EXPOSURE ; NMR ; TOXICITY ; PROTEINS ; STRESS ; HEALTH
SubtypeArticle
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS IDWOS:000372765100025
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/17027
Collection中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorWu, HF (reprint author), Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
Affiliation1.Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS
2.Univ Chinese Acad Sci
Recommended Citation
GB/T 7714
Yu, DL,Ji, CL,Zhao, JM,et al. Proteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis[J]. CHEMOSPHERE,2016,150:194-201.
APA Yu, DL,Ji, CL,Zhao, JM,Wu, HF,&Wu, HF .(2016).Proteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis.CHEMOSPHERE,150,194-201.
MLA Yu, DL,et al."Proteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis".CHEMOSPHERE 150(2016):194-201.
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