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Protective effects of C-phycocyanin on alcohol-induced subacute liver injury in mice
Xia, D; Liu, B; Xin, WY; Liu, TS; Sun, JY; Liu, NN; Qin, S; Du, ZN; Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. bliu@yic.ac.cn
2016-04-01
Source PublicationJOURNAL OF APPLIED PHYCOLOGY
ISSN0921-8971
Volume28Issue:2Pages:765-772
Contribution Rank[Xia, Dong; Du, Zhenning] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; [Liu, Bing; Sun, Junyan; Liu, Nana; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Xin, Wenyu; Liu, Tongshen] Binzhou Med Univ, Sch Basic Med, Yantai 264003, Peoples R China
AbstractExcessive and long-term alcohol consumption leads to liver disease and low immunity. Extensive evidence suggests that C-phycocyanin (C-PC), a chromophore phycocyanobilin derived from Arthrospira (Spirulina) platensis, exerts protective effects against chemical-induced organ damage and improves immunity. In this study, we investigated whether C-PC could protect against ethanol-induced subacute liver injury and improve immunity. KM mice with ethanol-induced liver injury were established, and animals were divided into three groups that were treated with high, medium, and low doses of C-PC. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (CHOL), low-density lipoprotein (LDL), total bilirubin (TBIL), liver homogenate malondialdehyde (MDA), and superoxide dismutase (SOD) levels were measured. In addition, the number of thymus T cell subsets was assessed, and liver sections were examined pathologically. C-PC exhibited obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL, and MDA levels and increased SOD content significantly in the liver. C-PC also increased serum CD3+ and CD4+ cell activation and T cell proliferation significantly compared with the model group. The structure of the hepatic lobules was clear, the liver sinus returned to normal, and the liver cell cords were arranged in neat rows. Therefore, C-PC could protect against ethanol-induced subacute liver injury significantly.
KeywordC-phycocyanin Subacute Ethanol Liver Injury Improves Immunity Protective Effect
Department海岸带生物学与生物资源利用所重点实验室
DOI10.1007/s10811-015-0677-3
Funding OrganizationPublic science and technology research funds projects of ocean(201205027)
Indexed BySCI
WOS KeywordLIPID-PEROXIDATION ; CARBON-TETRACHLORIDE ; FATTY LIVER ; IN-VITRO ; CYTOCHROME-P450 2E1 ; SPIRULINA-PLATENSIS ; OXIDATIVE STRESS ; DISEASE ; RATS ; ETHANOL
SubtypeArticle
Language英语
WOS Research AreaBiotechnology & Applied Microbiology ; Marine & Freshwater Biology
WOS IDWOS:000372256900006
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/10849
Collection海岸带生物学与生物资源保护实验室
Corresponding AuthorQin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. bliu@yic.ac.cn
Affiliation1.Yantai Univ, Sch Pharm
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat
3.Binzhou Med Univ, Sch Basic Med
Recommended Citation
GB/T 7714
Xia, D,Liu, B,Xin, WY,et al. Protective effects of C-phycocyanin on alcohol-induced subacute liver injury in mice[J]. JOURNAL OF APPLIED PHYCOLOGY,2016,28(2):765-772.
APA Xia, D.,Liu, B.,Xin, WY.,Liu, TS.,Sun, JY.,...&Qin, S .(2016).Protective effects of C-phycocyanin on alcohol-induced subacute liver injury in mice.JOURNAL OF APPLIED PHYCOLOGY,28(2),765-772.
MLA Xia, D,et al."Protective effects of C-phycocyanin on alcohol-induced subacute liver injury in mice".JOURNAL OF APPLIED PHYCOLOGY 28.2(2016):765-772.
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