Protective effects of C-phycocyanin on alcohol-induced subacute liver injury in mice

doi:10.1007/s10811-015-0677-3

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	Protective effects of C-phycocyanin on alcohol-induced subacute liver injury in mice
	Xia, D ; Liu, B; Xin, WY ; Liu, TS ; Sun, JY ; Liu, NN ; Qin, S; Du, ZN ; Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. bliu@yic.ac.cn
发表期刊	JOURNAL OF APPLIED PHYCOLOGY
ISSN	0921-8971
	2016-04-01
卷号	28 期号:2 页码:765-772
关键词	C-phycocyanin Subacute Ethanol Liver Injury Improves Immunity Protective Effect
DOI	10.1007/s10811-015-0677-3
产权排序	[Xia, Dong; Du, Zhenning] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; [Liu, Bing; Sun, Junyan; Liu, Nana; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Xin, Wenyu; Liu, Tongshen] Binzhou Med Univ, Sch Basic Med, Yantai 264003, Peoples R China
作者部门	海岸带生物学与生物资源利用所重点实验室
英文摘要	Excessive and long-term alcohol consumption leads to liver disease and low immunity. Extensive evidence suggests that C-phycocyanin (C-PC), a chromophore phycocyanobilin derived from Arthrospira (Spirulina) platensis, exerts protective effects against chemical-induced organ damage and improves immunity. In this study, we investigated whether C-PC could protect against ethanol-induced subacute liver injury and improve immunity. KM mice with ethanol-induced liver injury were established, and animals were divided into three groups that were treated with high, medium, and low doses of C-PC. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (CHOL), low-density lipoprotein (LDL), total bilirubin (TBIL), liver homogenate malondialdehyde (MDA), and superoxide dismutase (SOD) levels were measured. In addition, the number of thymus T cell subsets was assessed, and liver sections were examined pathologically. C-PC exhibited obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL, and MDA levels and increased SOD content significantly in the liver. C-PC also increased serum CD3+ and CD4+ cell activation and T cell proliferation significantly compared with the model group. The structure of the hepatic lobules was clear, the liver sinus returned to normal, and the liver cell cords were arranged in neat rows. Therefore, C-PC could protect against ethanol-induced subacute liver injury significantly.
文章类型	Article
资助机构	Public science and technology research funds projects of ocean(201205027)
收录类别	SCI
语种	英语
关键词[WOS]	LIPID-PEROXIDATION ; CARBON-TETRACHLORIDE ; FATTY LIVER ; IN-VITRO ; CYTOCHROME-P450 2E1 ; SPIRULINA-PLATENSIS ; OXIDATIVE STRESS ; DISEASE ; RATS ; ETHANOL
研究领域[WOS]	Biotechnology & Applied Microbiology ; Marine & Freshwater Biology
WOS记录号	WOS:000372256900006
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/10849
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者	Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. bliu@yic.ac.cn
作者单位	1.Yantai Univ, Sch Pharm 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat 3.Binzhou Med Univ, Sch Basic Med
推荐引用方式 GB/T 7714	Xia, D,Liu, B,Xin, WY,et al. Protective effects of C-phycocyanin on alcohol-induced subacute liver injury in mice[J]. JOURNAL OF APPLIED PHYCOLOGY,2016,28(2):765-772.
APA	Xia, D.,Liu, B.,Xin, WY.,Liu, TS.,Sun, JY.,...&Qin, S .(2016).Protective effects of C-phycocyanin on alcohol-induced subacute liver injury in mice.JOURNAL OF APPLIED PHYCOLOGY,28(2),765-772.
MLA	Xia, D,et al."Protective effects of C-phycocyanin on alcohol-induced subacute liver injury in mice".JOURNAL OF APPLIED PHYCOLOGY 28.2(2016):765-772.

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