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题名:
Alkaloids from an algicolous strain of Talaromyces sp.
作者: Yang, HB; Li, F; Ji, NY
刊名: CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN号: 0254-4059
出版日期: 2016-03-01
卷号: 34, 期号:2, 页码:367-371
关键词: Talaromyces sp. ; alkaloid ; chiral separation ; quantum chemical calculation ; bioactivity
DOI: 10.1007/s00343-015-4316-2
产权排序: [Yang Haibin; Li Fang] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China; [Yang Haibin; Ji Naiyun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
通讯作者: Li, F (reprint author), Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China. ; Ji, NY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. iceli_2003@126.com ; nyji@yic.ac.cn
作者部门: 海岸带生物学与生物资源利用所重点实验室
英文摘要: Compounds isolated and identified in a culture of the alga-endophytic fungus Talaromyces sp. cf-16 included two naturally occurring alkaloids, 2-[(S)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one (1a) and 2-[(R)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one (1b), that were identified for the first time. In addition, seven known compounds (2-8) were obtained from the culture. Following chiral column chromatography, compounds 1a and 1b were identified as enantiomers by spectroscopic analyses and quantum chemical calculations. Bioassay results showed that 5 was more toxic to brine shrimp than the other compounds, and that 3-6 could inhibit Staphylococcus aureus.
研究领域[WOS]: Marine & Freshwater Biology ; Oceanography
项目资助者: National Key Technology Research and Development Program for Agriculture(2012BAD32B09) ; National Natural Science Foundation of China(41106137 ; Taishan Scholar Program of Shandong Province ; Chinese Academy of Sciences for Key Topics in Innovation Engineering(KZCX2-YW-QN209) ; 41106136)
关键词[WOS]: ELECTRONIC CIRCULAR-DICHROISM ; ABSOLUTE-CONFIGURATIONS ; ASPERGILLUS-VERSICOLOR ; OPTICAL-ROTATION ; NATURAL-PRODUCTS ; ROQUEFORTINE ; METABOLITES ; MYCOTOXIN
文章类型: Article
收录类别: SCI
语种: 英语
WOS记录号: WOS:000371607000011
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内容类型: 期刊论文
URI标识: http://ir.yic.ac.cn/handle/133337/10846
Appears in Collections:海岸带生物学与生物资源利用所重点实验室_期刊论文

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作者单位: 1.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat

Recommended Citation:
Yang, HB,Li, F,Ji, NY. Alkaloids from an algicolous strain of Talaromyces sp.[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2016,34(2):367-371.
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