[Yang Haibin; Li Fang] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China; [Yang Haibin; Ji Naiyun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
通讯作者:
Li, F (reprint author), Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China.
; Ji, NY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. iceli_2003@126.com
; nyji@yic.ac.cn
作者部门:
海岸带生物学与生物资源利用所重点实验室
英文摘要:
Compounds isolated and identified in a culture of the alga-endophytic fungus Talaromyces sp. cf-16 included two naturally occurring alkaloids, 2-[(S)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one (1a) and 2-[(R)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one (1b), that were identified for the first time. In addition, seven known compounds (2-8) were obtained from the culture. Following chiral column chromatography, compounds 1a and 1b were identified as enantiomers by spectroscopic analyses and quantum chemical calculations. Bioassay results showed that 5 was more toxic to brine shrimp than the other compounds, and that 3-6 could inhibit Staphylococcus aureus.
研究领域[WOS]:
Marine & Freshwater Biology
; Oceanography
项目资助者:
National Key Technology Research and Development Program for Agriculture(2012BAD32B09)
; National Natural Science Foundation of China(41106137
; Taishan Scholar Program of Shandong Province
; Chinese Academy of Sciences for Key Topics in Innovation Engineering(KZCX2-YW-QN209)
; 41106136)
