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Alkaloids from an algicolous strain of Talaromyces sp.
Yang, HB; Li, F; Ji, NY; Li, F (reprint author), Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China.; Ji, NY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. iceli_2003@126.com; nyji@yic.ac.cn
2016-03-01
Source PublicationCHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN0254-4059
Volume34Issue:2Pages:367-371
Contribution Rank[Yang Haibin; Li Fang] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China; [Yang Haibin; Ji Naiyun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
AbstractCompounds isolated and identified in a culture of the alga-endophytic fungus Talaromyces sp. cf-16 included two naturally occurring alkaloids, 2-[(S)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one (1a) and 2-[(R)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one (1b), that were identified for the first time. In addition, seven known compounds (2-8) were obtained from the culture. Following chiral column chromatography, compounds 1a and 1b were identified as enantiomers by spectroscopic analyses and quantum chemical calculations. Bioassay results showed that 5 was more toxic to brine shrimp than the other compounds, and that 3-6 could inhibit Staphylococcus aureus.
KeywordTalaromyces Sp. Alkaloid Chiral Separation Quantum Chemical Calculation Bioactivity
Department海岸带生物学与生物资源利用所重点实验室
DOI10.1007/s00343-015-4316-2
Funding OrganizationNational Key Technology Research and Development Program for Agriculture(2012BAD32B09) ; National Natural Science Foundation of China(41106137 ; Taishan Scholar Program of Shandong Province ; Chinese Academy of Sciences for Key Topics in Innovation Engineering(KZCX2-YW-QN209) ; 41106136)
Indexed BySCI
WOS KeywordELECTRONIC CIRCULAR-DICHROISM ; ABSOLUTE-CONFIGURATIONS ; ASPERGILLUS-VERSICOLOR ; OPTICAL-ROTATION ; NATURAL-PRODUCTS ; ROQUEFORTINE ; METABOLITES ; MYCOTOXIN
SubtypeArticle
Language英语
WOS Research AreaMarine & Freshwater Biology ; Oceanography
WOS IDWOS:000371607000011
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/10846
Collection海岸带生物学与生物资源保护实验室
Corresponding AuthorLi, F (reprint author), Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China.; Ji, NY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. iceli_2003@126.com; nyji@yic.ac.cn
Affiliation1.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat
Recommended Citation
GB/T 7714
Yang, HB,Li, F,Ji, NY,et al. Alkaloids from an algicolous strain of Talaromyces sp.[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2016,34(2):367-371.
APA Yang, HB,Li, F,Ji, NY,Li, F ,Ji, NY ,&nyji@yic.ac.cn.(2016).Alkaloids from an algicolous strain of Talaromyces sp..CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,34(2),367-371.
MLA Yang, HB,et al."Alkaloids from an algicolous strain of Talaromyces sp.".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 34.2(2016):367-371.
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