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Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice
Xia, D; Liu, B; Luan, XY; Sun, JY; Liu, NN; Qin, S; Du, ZN; Du, ZN (reprint author), Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China.; Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. sqin@yic.ac.cn; zhenning.du@163.com
2016-03-01
Source PublicationCHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN0254-4059
Volume34Issue:2Pages:399-404
Contribution Rank[Xia Dong; Du Zhenning] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; [Liu Bing; Sun Junyan; Liu Nana; Qin Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Luan Xiying] Binzhou Med Univ, Sch Basic Med, Yantai 264003, Peoples R China
AbstractExcessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin (C-PC), a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective effects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (CHOL), low-density lipoprotein (LDL), liver homogenate malondialdehyde (MDA), superoxide dismutase (SOD) content were measured, and pathological examination of liver sections were examined. C-PC showed obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL and MDA, and SOD content significantly increased in the liver. The structure of hepatic lobules was clear, liver sinus returned to normal, and liver cell cords were arranged in neat rows. Cloudiness, swelling, inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore, C-PC can significantly protect against ethanol-induced acute liver injury.
KeywordC-phycocyanin Acute Ethanol Liver Injury Protective Effect
Department海岸带生物学与生物资源利用所重点实验室
DOI10.1007/s00343-015-4312-6
Funding OrganizationNational Special Research Fund for Non-Profit Marine Sector(201205027) ; Taishan Scholar Program of Shandong Province
Indexed BySCI
WOS KeywordFATTY LIVER ; IN-VITRO ; DISEASE ; ANTIOXIDANT ; PROGRESSION ; HEALTH ; VIVO
SubtypeArticle
Language英语
WOS Research AreaMarine & Freshwater Biology ; Oceanography
WOS IDWOS:000371607000016
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/10838
Collection海岸带生物学与生物资源保护实验室
Corresponding AuthorDu, ZN (reprint author), Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China.; Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. sqin@yic.ac.cn; zhenning.du@163.com
Affiliation1.Yantai Univ, Sch Pharm
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat
3.Binzhou Med Univ, Sch Basic Med
Recommended Citation
GB/T 7714
Xia, D,Liu, B,Luan, XY,et al. Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2016,34(2):399-404.
APA Xia, D.,Liu, B.,Luan, XY.,Sun, JY.,Liu, NN.,...&zhenning.du@163.com.(2016).Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,34(2),399-404.
MLA Xia, D,et al."Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 34.2(2016):399-404.
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