Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice

doi:10.1007/s00343-015-4312-6

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	Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice
	Xia, D ; Liu, B; Luan, XY ; Sun, JY ; Liu, NN ; Qin, S; Du, ZN ; Du, ZN (reprint author), Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China.; Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. sqin@yic.ac.cn ; zhenning.du@163.com
发表期刊	CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN	0254-4059
	2016-03-01
卷号	34 期号:2 页码:399-404
关键词	C-phycocyanin Acute Ethanol Liver Injury Protective Effect
DOI	10.1007/s00343-015-4312-6
产权排序	[Xia Dong; Du Zhenning] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; [Liu Bing; Sun Junyan; Liu Nana; Qin Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Luan Xiying] Binzhou Med Univ, Sch Basic Med, Yantai 264003, Peoples R China
作者部门	海岸带生物学与生物资源利用所重点实验室
英文摘要	Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin (C-PC), a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective effects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (CHOL), low-density lipoprotein (LDL), liver homogenate malondialdehyde (MDA), superoxide dismutase (SOD) content were measured, and pathological examination of liver sections were examined. C-PC showed obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL and MDA, and SOD content significantly increased in the liver. The structure of hepatic lobules was clear, liver sinus returned to normal, and liver cell cords were arranged in neat rows. Cloudiness, swelling, inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore, C-PC can significantly protect against ethanol-induced acute liver injury.
文章类型	Article
资助机构	National Special Research Fund for Non-Profit Marine Sector(201205027) ; Taishan Scholar Program of Shandong Province
收录类别	SCI
语种	英语
关键词[WOS]	FATTY LIVER ; IN-VITRO ; DISEASE ; ANTIOXIDANT ; PROGRESSION ; HEALTH ; VIVO
研究领域[WOS]	Marine & Freshwater Biology ; Oceanography
WOS记录号	WOS:000371607000016
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/10838
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者	Du, ZN (reprint author), Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China.; Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. sqin@yic.ac.cn; zhenning.du@163.com
作者单位	1.Yantai Univ, Sch Pharm 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat 3.Binzhou Med Univ, Sch Basic Med
推荐引用方式 GB/T 7714	Xia, D,Liu, B,Luan, XY,et al. Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2016,34(2):399-404.
APA	Xia, D.,Liu, B.,Luan, XY.,Sun, JY.,Liu, NN.,...&zhenning.du@163.com.(2016).Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,34(2),399-404.
MLA	Xia, D,et al."Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 34.2(2016):399-404.

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