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题名:
Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice
作者: Xia, D; Liu, B; Luan, XY; Sun, JY; Liu, NN; Qin, S; Du, ZN
刊名: CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN号: 0254-4059
出版日期: 2016-03-01
卷号: 34, 期号:2, 页码:399-404
关键词: C-phycocyanin ; acute ethanol liver injury ; protective effect
DOI: 10.1007/s00343-015-4312-6
产权排序: [Xia Dong; Du Zhenning] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; [Liu Bing; Sun Junyan; Liu Nana; Qin Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Luan Xiying] Binzhou Med Univ, Sch Basic Med, Yantai 264003, Peoples R China
通讯作者: Du, ZN (reprint author), Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China. ; Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. sqin@yic.ac.cn ; zhenning.du@163.com
作者部门: 海岸带生物学与生物资源利用所重点实验室
英文摘要: Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin (C-PC), a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective effects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (CHOL), low-density lipoprotein (LDL), liver homogenate malondialdehyde (MDA), superoxide dismutase (SOD) content were measured, and pathological examination of liver sections were examined. C-PC showed obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL and MDA, and SOD content significantly increased in the liver. The structure of hepatic lobules was clear, liver sinus returned to normal, and liver cell cords were arranged in neat rows. Cloudiness, swelling, inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore, C-PC can significantly protect against ethanol-induced acute liver injury.
研究领域[WOS]: Marine & Freshwater Biology ; Oceanography
项目资助者: National Special Research Fund for Non-Profit Marine Sector(201205027) ; Taishan Scholar Program of Shandong Province
关键词[WOS]: FATTY LIVER ; IN-VITRO ; DISEASE ; ANTIOXIDANT ; PROGRESSION ; HEALTH ; VIVO
文章类型: Article
收录类别: SCI
语种: 英语
WOS记录号: WOS:000371607000016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.yic.ac.cn/handle/133337/10838
Appears in Collections:海岸带生物学与生物资源利用所重点实验室_期刊论文

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作者单位: 1.Yantai Univ, Sch Pharm
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat
3.Binzhou Med Univ, Sch Basic Med

Recommended Citation:
Xia, D,Liu, B,Luan, XY,et al. Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2016,34(2):399-404.
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文件名: Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice.pdf
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