Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice
Xia, D; Liu, B; Luan, XY; Sun, JY; Liu, NN; Qin, S; Du, ZN; Du, ZN (reprint author), Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China.; Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. sqin@yic.ac.cn; zhenning.du@163.com
2016-03-01
发表期刊CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN0254-4059
卷号34期号:2页码:399-404
产权排序[Xia Dong; Du Zhenning] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; [Liu Bing; Sun Junyan; Liu Nana; Qin Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Luan Xiying] Binzhou Med Univ, Sch Basic Med, Yantai 264003, Peoples R China
摘要Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin (C-PC), a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective effects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (CHOL), low-density lipoprotein (LDL), liver homogenate malondialdehyde (MDA), superoxide dismutase (SOD) content were measured, and pathological examination of liver sections were examined. C-PC showed obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL and MDA, and SOD content significantly increased in the liver. The structure of hepatic lobules was clear, liver sinus returned to normal, and liver cell cords were arranged in neat rows. Cloudiness, swelling, inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore, C-PC can significantly protect against ethanol-induced acute liver injury.
关键词C-phycocyanin Acute Ethanol Liver Injury Protective Effect
作者部门海岸带生物学与生物资源利用所重点实验室
DOI10.1007/s00343-015-4312-6
项目资助者National Special Research Fund for Non-Profit Marine Sector(201205027) ; Taishan Scholar Program of Shandong Province
收录类别SCI
关键词[WOS]FATTY LIVER ; IN-VITRO ; DISEASE ; ANTIOXIDANT ; PROGRESSION ; HEALTH ; VIVO
文章类型Article
语种英语
WOS研究方向Marine & Freshwater Biology ; Oceanography
WOS记录号WOS:000371607000016
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/10838
专题海岸带生物学与生物资源利用所重点实验室
通讯作者Du, ZN (reprint author), Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China.; Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. sqin@yic.ac.cn; zhenning.du@163.com
作者单位1.Yantai Univ, Sch Pharm
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat
3.Binzhou Med Univ, Sch Basic Med
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GB/T 7714
Xia, D,Liu, B,Luan, XY,et al. Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2016,34(2):399-404.
APA Xia, D.,Liu, B.,Luan, XY.,Sun, JY.,Liu, NN.,...&zhenning.du@163.com.(2016).Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,34(2),399-404.
MLA Xia, D,et al."Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 34.2(2016):399-404.
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